Types of General Anesthetics

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Questions and Answers

What is the main reason for the decline in the use of halogenated ethers and hydrocarbons as general anesthetics?

  • Preference for liquid anesthetics over gases
  • Unavailability in various countries
  • Increased cost of production
  • Associated hepatic injury and liver failure (correct)

How have newer anesthetics been modified to provide an increased margin of safety compared to traditional agents?

  • Decreased toxicity
  • Production as solids instead of gases
  • Development of enantiomers (correct)
  • Increased potency

What is one advantage of enantiomers of anesthetics compared to the same compounds?

  • Reduced need for potent drugs (correct)
  • More adverse side effects
  • Increased toxicity
  • Higher production cost

According to Whyte et al., what patient populations could benefit from gaseous anesthetics that do not affect mentation or memory?

<p>Geriatric, pediatric, and mental impairment patients (D)</p> Signup and view all the answers

What is a significant feature of newer chemical groups of inhalation anesthetics compared to halothane and ether anesthetics?

<p>Less potency and toxicity (C)</p> Signup and view all the answers

What is the primary focus of the review by Whyte et al. regarding modern anesthetics?

<p>Properties and benefits compared to older agents (C)</p> Signup and view all the answers

Which inhalation general anesthetic is commonly used for its anxiolytic and analgesic properties during procedures without general anesthesia?

<p>Nitrous oxide (D)</p> Signup and view all the answers

What are the reasons for the decline in popularity of halothane in the US?

<p>User-friendliness (C)</p> Signup and view all the answers

Which high-potency noble gas has unique anesthetic properties but is limited in clinical use due to its cost and scarcity?

<p>Xenon (A)</p> Signup and view all the answers

Why may slow recovery from long infusions of thiopental be observed?

<p>Peripheral drug accumulation (B)</p> Signup and view all the answers

What is the main reason for the development of newer IV agents following cardiovascular collapse after thiopental use?

<p>Myocardial depressive effects (D)</p> Signup and view all the answers

What stage of sleep does anesthesia induced by thiopentone closely resemble?

<p><strong>NREM stage 3 or 4</strong> (D)</p> Signup and view all the answers

Flashcards

Decline of Halogenated Anesthetics

Halogenated ethers and hydrocarbons fell out of favor due to the risk of hepatic injury and liver failure.

Anesthetic Enantiomers

Newer anesthetics have been modified as enantiomers to enhance safety.

Advantage of Enantiomers

Enantiomers can reduce risks by lowering the necessary dose of potent drugs.

Ideal Candidates for Gaseous Anesthetics

Geriatric, pediatric, and patients with mental impairments could especially benefit from it.

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Features of Modern Anesthetics

Newer anesthetics have less potency and toxicity compared to older agents like halothane and ether.

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Whyte et al. Review Focus

The review focuses on the properties and benefits of modern anesthetics compared to older alternatives.

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Nitrous Oxide Use

Nitrous oxide is used for its anxiolytic and analgesic effects in procedures without general anesthesia.

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Halothane Decline in US

Halothane's popularity declined in the US because of user-friendliness.

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Limitations of Xenon

Xenon, a high-potency noble gas, is limited due to cost and scarcity, despite its unique anesthetic properties.

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Thiopental Recovery

Slow recovery may occur due to peripheral drug accumulation during long infusions.

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Development of Newer IV Agents

Newer IV agents were developed to avoid myocardial depressive effects that could lead to cardiovascular collapse.

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Thiopentone sleep stage

Anesthesia induced by thiopentone closely resembles NREM stage 3 or 4 sleep.

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