Tumour Pathology: Oropharynx, Esophagus, Stomach
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Questions and Answers

Which genetic syndrome is associated with the development of gastric polyps of foveolar-type?

  • Familial polyposis syndrome
  • Autoimmune gastritis
  • Familial adenomatous polyposis (FAP) (correct)
  • Chronic gastritis

Which type of gastric polyp is most common in the distal stomach?

  • Fundic gland polyp
  • Carcinoid tumor
  • Hyperplastic polyp (correct)
  • Adenoma

What is the primary etiological factor for the development of intestinal-type adenomas?

  • Helicobacter pylori infection (correct)
  • Mutation in APC gene
  • Autoimmune gastritis
  • Proton pump inhibitor use

Which of the following is NOT considered a malignant gastric tumor?

<p>Fundic gland polyp (D)</p> Signup and view all the answers

In which age group do adenomas (Intestinal-type or foveolar-type) commonly develop?

<p>Sixth or seventh decade of life (A)</p> Signup and view all the answers

What is the pathogenesis of hyperplastic polyps in the stomach related to?

<p>Proton pump inhibitor use leading to glandular hyperplasia (C)</p> Signup and view all the answers

What type of lesions can be associated with adenocarcinoma in the esophagus?

<p>Fungating (C)</p> Signup and view all the answers

What type of metaplasia is commonly seen in the adjacent mucosa of esophageal adenocarcinoma?

<p>Barrett esophagus (C)</p> Signup and view all the answers

Which characteristic is NOT typically observed in the morphology of malignant esophageal glands?

<p>Stratified arrangement (C)</p> Signup and view all the answers

Which of the following features is indicative of Barrett dysplasia?

<p>Loss of nuclear polarity (C)</p> Signup and view all the answers

Which type of adenocarcinoma is characterized by uninvolved normal squamous mucosa to the left?

<p>Mucinous-producing invasive adenocarcinoma (D)</p> Signup and view all the answers

Which type of carcinoma is most commonly associated with high-risk HPV, type 16, through oral sex?

<p>Squamous cell carcinoma, HPV-positive (D)</p> Signup and view all the answers

What is the main etiology factor for the development of Squamous papilloma in the esophagus?

<p>Genetic syndromes (C)</p> Signup and view all the answers

Where is the most common anatomical location for adenocarcinoma in the esophagus?

<p>Lower third of the esophagus (B)</p> Signup and view all the answers

Which of the following is NOT a risk factor for the development of esophageal adenocarcinoma?

<p>Helicobacter pylori infection (B)</p> Signup and view all the answers

What is the typical clinical presentation in the late stages of squamous cell carcinoma of the esophagus?

<p>Dysphagia, chest pain, painful swallowing and weight loss (B)</p> Signup and view all the answers

'Barrett esophagus' is a precursor lesion to which type of esophageal cancer?

<p>Adenocarcinoma (C)</p> Signup and view all the answers

'Koilocytes' are typically seen in histopathology slides of which esophageal condition?

<p>Squamous papilloma (A)</p> Signup and view all the answers

'Desmoplastic stroma' is a characteristic feature seen in which type of oropharyngeal squamous cell carcinoma?

<p>'HPV-negative form' (C)</p> Signup and view all the answers

Which factor has a higher association with HPV-positive oropharyngeal squamous cell carcinoma?

<p>Sexual behavior (D)</p> Signup and view all the answers

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