Tumour Pathology: Oropharynx, Esophagus, Stomach
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Questions and Answers

Which genetic syndrome is associated with the development of gastric polyps of foveolar-type?

  • Familial polyposis syndrome
  • Autoimmune gastritis
  • Familial adenomatous polyposis (FAP) (correct)
  • Chronic gastritis
  • Which type of gastric polyp is most common in the distal stomach?

  • Fundic gland polyp
  • Carcinoid tumor
  • Hyperplastic polyp (correct)
  • Adenoma
  • What is the primary etiological factor for the development of intestinal-type adenomas?

  • Helicobacter pylori infection (correct)
  • Mutation in APC gene
  • Autoimmune gastritis
  • Proton pump inhibitor use
  • Which of the following is NOT considered a malignant gastric tumor?

    <p>Fundic gland polyp</p> Signup and view all the answers

    In which age group do adenomas (Intestinal-type or foveolar-type) commonly develop?

    <p>Sixth or seventh decade of life</p> Signup and view all the answers

    What is the pathogenesis of hyperplastic polyps in the stomach related to?

    <p>Proton pump inhibitor use leading to glandular hyperplasia</p> Signup and view all the answers

    What type of lesions can be associated with adenocarcinoma in the esophagus?

    <p>Fungating</p> Signup and view all the answers

    What type of metaplasia is commonly seen in the adjacent mucosa of esophageal adenocarcinoma?

    <p>Barrett esophagus</p> Signup and view all the answers

    Which characteristic is NOT typically observed in the morphology of malignant esophageal glands?

    <p>Stratified arrangement</p> Signup and view all the answers

    Which of the following features is indicative of Barrett dysplasia?

    <p>Loss of nuclear polarity</p> Signup and view all the answers

    Which type of adenocarcinoma is characterized by uninvolved normal squamous mucosa to the left?

    <p>Mucinous-producing invasive adenocarcinoma</p> Signup and view all the answers

    Which type of carcinoma is most commonly associated with high-risk HPV, type 16, through oral sex?

    <p>Squamous cell carcinoma, HPV-positive</p> Signup and view all the answers

    What is the main etiology factor for the development of Squamous papilloma in the esophagus?

    <p>Genetic syndromes</p> Signup and view all the answers

    Where is the most common anatomical location for adenocarcinoma in the esophagus?

    <p>Lower third of the esophagus</p> Signup and view all the answers

    Which of the following is NOT a risk factor for the development of esophageal adenocarcinoma?

    <p>Helicobacter pylori infection</p> Signup and view all the answers

    What is the typical clinical presentation in the late stages of squamous cell carcinoma of the esophagus?

    <p>Dysphagia, chest pain, painful swallowing and weight loss</p> Signup and view all the answers

    'Barrett esophagus' is a precursor lesion to which type of esophageal cancer?

    <p>Adenocarcinoma</p> Signup and view all the answers

    'Koilocytes' are typically seen in histopathology slides of which esophageal condition?

    <p>Squamous papilloma</p> Signup and view all the answers

    'Desmoplastic stroma' is a characteristic feature seen in which type of oropharyngeal squamous cell carcinoma?

    <p>'HPV-negative form'</p> Signup and view all the answers

    Which factor has a higher association with HPV-positive oropharyngeal squamous cell carcinoma?

    <p>Sexual behavior</p> Signup and view all the answers

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