Triptans for Migraine Treatment

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Questions and Answers

What is the primary mechanism of action for triptans in treating migraines?

  • Causing vasodilation of cranial blood vessels
  • Increasing serotonin levels in the central nervous system
  • Causing vasoconstriction of cranial blood vessels (correct)
  • Blocking dopamine receptors in the brain

Which of the following is a common route of administration for triptans?

  • Oral (correct)
  • Inhalation
  • Intramuscular
  • Transdermal

Which of the following is a contraindication for using triptans?

  • Coronary artery disease (CAD) (correct)
  • Type 2 diabetes
  • Osteoporosis
  • Hypothyroidism

For what condition are triptans indicated?

<p>Treatment of acute migraines (B)</p> Signup and view all the answers

What is a potential drug-drug interaction concern when prescribing triptans?

<p>Ergots (D)</p> Signup and view all the answers

Which of the following is an example of a triptan medication?

<p>Naratriptan (A)</p> Signup and view all the answers

What population group is generally contraindicated for the use of triptans?

<p>Elderly (B)</p> Signup and view all the answers

Which route of administration allows for the fastest absorption of sumatriptan?

<p>IV (C)</p> Signup and view all the answers

A patient with a history of which condition should avoid eletriptan?

<p>Coronary artery disease (D)</p> Signup and view all the answers

If a patient experiences adverse effects from ergots, they are likely to experience similar effects from which drug class?

<p>Triptans (B)</p> Signup and view all the answers

Flashcards

Triptans: Mechanism & Use

Bind to serotonin receptors, causing cranial vessel vasoconstriction, used for acute migraine treatment, not prevention.

Common Triptan Names

Sumatriptan, Naratriptan, Eletriptan

Triptan Routes of Administration

IV, Sub-Q, Oral

Triptan Contraindications

Elderly patients, CAD, pregnancy/lactation, renal/hepatic dysfunction

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Triptan Adverse Effects

Similar to ergots.

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Triptan Drug Interaction

Ergots

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Study Notes

Triptans

  • Triptans selectively bind to serotonin receptor sites.
  • This binding action induces vasoconstriction in cranial vessels.
  • Triptans include Naratriptan, sumatriptan, and eletriptan.
  • They are indicated for the acute treatment of migraines.
  • They are not used to prevent migraines.
  • Triptans can be administered intravenously, subcutaneously, or orally.
  • Contraindications include elderly patients, coronary artery disease (CAD), pregnancy/lactation, and renal or hepatic dysfunction.
  • Adverse effects mirror those of ergots.
  • Triptans have a drug-drug interaction with ergots.

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