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Trimeric G Protein Signaling Mechanism Quiz

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Trimeric G Protein Signaling Mechanism Quiz

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Questions and Answers

What is the function of the α subunit of the Trimeric G Protein?

Inhibiting GTP hydrolysis

Regulating GAP activity

Enhancing GTP hydrolysis (correct)

Promoting GPCR activation

Which role do RGS proteins play in the GTPase cycle of Trimeric G Proteins?

Enhancing GDP dissociation

Acting as GAPs for α-subunit-specific GTPase activation (correct)

Stimulating GTP hydrolysis

Promoting GPCR activation

How does a Trimeric G Protein become inactive?

By dissociating from the receptor

By enhancing GTP hydrolysis

By binding to GDP (correct)

By promoting GPCR activation

Which component of the Trimeric G Protein has lipid molecules attached to help bind to the plasma membrane?

γ subunit Signup and view all the answers

What is the function of Guanine Exchange Factors (GEFs) in the GTPase cycle of Trimeric G Proteins?

Enhancing GTP binding Signup and view all the answers

How do GAPs regulate Trimeric G Proteins?

Enhancing GTP hydrolysis Signup and view all the answers

What is the role of a Guanine Exchange Factor (GEF) in GPCR signaling?

It activates the G protein by inducing the release of GDP and binding of GTP. Signup and view all the answers

How many subunits make up a Trimeric G protein?

Three subunits Signup and view all the answers

What happens to the α-subunit of a Trimeric G protein in its unstimulated state?

It binds to GDP and is inactive. Signup and view all the answers

Which part of the Trimeric G protein binds to GDP in its inactive state?

α-subunit Signup and view all the answers

How does the ligand binding to a GPCR affect the associated Trimeric G protein?

It induces the α-subunit to release GDP and bind GTP. Signup and view all the answers

Where does the ligand bind in a typical Trimeric GPCR structure?

Near the N terminus Signup and view all the answers

What is the role of Guanine nucleotide-dissociation inhibitors (GDIs) in G protein signaling?

Prevent GDP/GTP exchange Signup and view all the answers

How do Regulatory proteins of G protein Signalling (RGS) contribute to G protein responses?

Act as α-subunit specific GAPs to shut off G protein-mediated responses Signup and view all the answers

How many RGS proteins are encoded in the human genome?

25 Signup and view all the answers

Which of the following families of trimeric G proteins are involved in GPCR signaling pathways?

4 families Signup and view all the answers

What is the signaling effect of cAMP activation by Gs on plasma membrane-bound enzymes?

Activation of CREB transcription factor Signup and view all the answers