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Questions and Answers
What is the drug classification of Trifluoperazine (Stelazine)?
What is the drug classification of Trifluoperazine (Stelazine)?
Phenothiazines
What is the route of administration for Trifluoperazine (Stelazine)?
What is the route of administration for Trifluoperazine (Stelazine)?
PO
What are the indications for Trifluoperazine (Stelazine)? (Select all that apply)
What are the indications for Trifluoperazine (Stelazine)? (Select all that apply)
Which of the following are side effects of Trifluoperazine (Stelazine)? (Select all that apply)
Which of the following are side effects of Trifluoperazine (Stelazine)? (Select all that apply)
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What should be monitored as a nursing responsibility when administering Trifluoperazine (Stelazine)?
What should be monitored as a nursing responsibility when administering Trifluoperazine (Stelazine)?
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What is the primary action of Trifluoperazine (Stelazine)?
What is the primary action of Trifluoperazine (Stelazine)?
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What is a contraindication for Trifluoperazine (Stelazine)? (Select all that apply)
What is a contraindication for Trifluoperazine (Stelazine)? (Select all that apply)
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What conditions require caution when administering Trifluoperazine (Stelazine)? (Select all that apply)
What conditions require caution when administering Trifluoperazine (Stelazine)? (Select all that apply)
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What type of drug interactions does Trifluoperazine (Stelazine) have with antihypertensives?
What type of drug interactions does Trifluoperazine (Stelazine) have with antihypertensives?
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Study Notes
Trifluoperazine (Stelazine) Overview
- Classification: Antipsychotic, part of the phenothiazines family.
- Route of administration: Oral (PO).
- Protein binding: Greater than 90%.
- Pregnancy category: C (risk cannot be ruled out).
- Metabolism: Primarily metabolized by the liver.
Indications
- Used for treating schizophrenia, non-psychotic anxiety, and bipolar disorder.
Side Effects
- Severe reactions include neuroleptic malignant syndrome and agranulocytosis.
- Common side effects: extrapyramidal reactions, sedation, and tardive dyskinesia.
- Other effects: dry eyes, blurred vision, lens opacities, hypotension, increased heart rate, constipation, anorexia, dry mouth, hepatitis, ileus, urinary retention, priapism, photosensitivity, pigment changes, rash, galactorrhea, amenorrhea, allergic reactions, prolonged QT wave, and elevated prolactin levels.
Nursing Responsibilities
- Monitor mental state and BMI regularly.
- Regularly assess vital signs.
- Watch for extrapyramidal signs like difficulty speaking, rigidity, tremors, and dystonia.
- Be alert for symptoms of tardive dyskinesia and neuroleptic malignant syndrome, including fever, muscle stiffness, and changes in blood pressure.
- Conduct complete blood counts (CBC), ocular exams, and liver function tests.
Drug Action
- Modifies dopamine effects in the central nervous system (CNS).
- Exhibits significant anticholinergic and alpha-adrenergic blockade.
Contraindications
- Hypersensitivity to the drug.
- Conditions such as angle-closure glaucoma, bone marrow depression, liver disease, and cardiovascular disease.
Cautions
- Use with caution in patients with diabetes, elderly individuals (due to increased mortality risk), respiratory distress, prostatic hyperplasia, CNS tumors, epilepsy, and intestinal obstruction.
Drug Interactions
- Can cause additive hypotensive effects when combined with antihypertensives, alcohol, and nitrates.
- Increases CNS depression when used with alcohol, antihistamines, opioids, sedatives, and anesthetics.
- Enhances anticholinergic effects with antihistamines, certain antidepressants, and other phenothiazines.
- Risk of acute encephalopathy when combined with lithium.
- Reduces the effectiveness of levodopa.
- Increased risk of agranulocytosis when used with antithyroid drugs.
- Lithium may decrease absorption and raise the risk of extrapyramidal reactions.
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Description
Test your knowledge on Trifluoperazine, its drug classification, indications, and side effects with this set of flashcards. Perfect for pharmacy students and healthcare professionals seeking to enhance their understanding of this antipsychotic medication.
