Tricyclic Antidepressants: Mechanism of Action and Clinical Applications

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HarmlessShofar
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6 Questions

What clinical features are associated with Grand Mal Epilepsy?

Loss of consciousness, tonic phase, clonic phase, severe fatigue and convulsions

What is the Drug of Choice for treating epilepsy as mentioned in the text?

Valproic acid

Which seizure type originates from both hemispheres according to the text?

Grand Mal seizure

What side effect is associated with Valproic acid use?

Fatty liver (leading to hepatitis)

Which drug is a metabolic inhibitor and acts as a sodium channel blocker & calcium channel blocker?

Valproic acid

What is the second-line treatment for epilepsy mentioned in the text?

Carbamazepine

Learn about the mechanism of action, effectiveness, and clinical applications of tricyclic antidepressants (TCAs). Explore how TCAs inhibit the reuptake of serotonin and norepinephrine, leading to increased appetite and weight gain due to the elevation of serotonin. Understand the use of TCAs as third/fourth-line treatment for major depression, neuropathic pain, chronic headaches, irritable bowel disease, fibromyalgia, and more.

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