Treatment of Recurrent Corneal Erosion (RCE) Quiz
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Questions and Answers

What is the primary adverse effect of tetracycline?

  • Diabetes
  • Intracranial hypertension
  • Discoloration of teeth (correct)
  • Bone growth suppression in adults

Why is it not advisable to take tetracycline during pregnancy or in children 8 years or younger?

  • It causes intracranial hypertension
  • It leads to cancer
  • It affects calcium metabolism (correct)
  • It suppresses bone growth in adults

What is a potential adverse reaction associated with minocycline use?

  • Intracranial hypertension
  • Pseudotumor cerebri (correct)
  • Decrease in bone growth
  • Transient visual obscurations

How long after using minocycline may pseudotumor develop?

<p>2 months to a year (C)</p> Signup and view all the answers

What is the mechanism by which minocycline may cause pseudotumor?

<p>Decrease in cerebrospinal fluid absorption (D)</p> Signup and view all the answers

What is the recommended treatment for resolving pseudotumor caused by minocycline?

<p>Discontinuation of the drug (B)</p> Signup and view all the answers

What is the potential residual effect of pseudotumor induced by minocycline?

<p>Visual field defect (A)</p> Signup and view all the answers

What is the primary use of tetracycline?

<p>Treatment of acne and rosacea (C)</p> Signup and view all the answers

What is the recommended dosage form for tetracycline?

<p>250 mg &amp; 500 mg capsules (B)</p> Signup and view all the answers

Why should tetracycline be taken on an empty stomach?

<p>To enhance its absorption (D)</p> Signup and view all the answers

What is the potential issue with tetracycline use during pregnancy and lactation?

<p>It can cause birth defects (B)</p> Signup and view all the answers

In what type of glands does tetracycline accumulate?

<p>Sebaceous glands (C)</p> Signup and view all the answers

What is the tetracycline of choice for treating chlamydia, acne, and rosacea?

<p>Doxycycline (B)</p> Signup and view all the answers

How long is tetracycline typically used for treating certain conditions such as meibomianitis?

<p>Months (A)</p> Signup and view all the answers

What is the main function of doxycycline in treating recurrent corneal erosion (RCE) according to the text?

<p>It reduces the activity of metalloproteinase-9 in the corneal epithelium (D)</p> Signup and view all the answers

What is the recommended dosage regimen for doxycycline (ORACEA) for treating rosacea?

<p>40 mg capsule taken once daily in the morning on an empty stomach (A)</p> Signup and view all the answers

In what condition has the enzyme metalloproteinase-9 been found to be increased, as mentioned in the text?

<p>Recurrent corneal erosion (RCE) (D)</p> Signup and view all the answers

What is the main effect of prednisolone acetate 1% or fluorometholone when used three times a day for 2-3 weeks, as per the text?

<p>It decreases the activity of metalloproteinase-9 in the corneal epithelium (A)</p> Signup and view all the answers

How is ORACEA (doxycycline) filled with different types of beads, according to the text?

<p>30mg immediate release and 10mg delayed release beads (C)</p> Signup and view all the answers

What has been found to help with recurrent corneal erosion (RCE) when caused by a fingernail cut?

<p>Doxycycline (C)</p> Signup and view all the answers

What is the effect of doxycycline on the enzyme metalloproteinase-9 in the corneal epithelium, based on the text?

<p>It decreases the activity of metalloproteinase-9 (B)</p> Signup and view all the answers

What is the purpose of oracea in relation to inflammation and bacteria?

<p>To decrease the inflammation caused by bacteria (C)</p> Signup and view all the answers

How does the antibiotic level of regular doxycycline compare to that of oracea?

<p>Regular doxycycline crosses the antibiotic level threshold more than oracea (A)</p> Signup and view all the answers

What is the specific combination of immediate and delayed release in oracea?

<p>40mg immediate release and 10mg delayed release (C)</p> Signup and view all the answers

Which enzyme is oracea primarily targeting?

<p>Enzymes involved in inflammation (C)</p> Signup and view all the answers

What dosage of oracea is recommended for an empty stomach?

<p>40mg once daily (A)</p> Signup and view all the answers

In the context of rosacea treatment, how long is the recommended tapering period for regular doxycycline?

<p>2 weeks (D)</p> Signup and view all the answers

Which other antibiotic is mentioned as a treatment option for rosacea?

<p>Erythromycin (D)</p> Signup and view all the answers

What is the primary mechanism of action of tetracycline?

<p>Inhibition of protein synthesis (C)</p> Signup and view all the answers

Which type of bacteria does tetracycline have activity against?

<p>Gram-positive and Gram-negative bacteria (A)</p> Signup and view all the answers

What is the role of tetracycline in the treatment of Chlamydia?

<p>It interferes with protein synthesis (A)</p> Signup and view all the answers

Why is resistance developed towards Staphylococcus aureus (S. aureus) for tetracycline?

<p>Increased efflux pumps (D)</p> Signup and view all the answers

What is the characteristic feature of tetracycline's activity on lipase production?

<p>Inhibition of lipase production (A)</p> Signup and view all the answers

What condition is related to the anticollagenolytic activity of systemic tetracycline?

<p>Corneal ulcers (A)</p> Signup and view all the answers

Why is it recommended to take tetracyclines without food?

<p>To ensure higher concentration in the system (B)</p> Signup and view all the answers

Which tetracycline is the exception and can be taken with food?

<p>Doxycycline (D)</p> Signup and view all the answers

What precaution should be taken after a patient takes doxycycline to avoid epigastric distress?

<p>Avoid lying down for at least 30 minutes (D)</p> Signup and view all the answers

Why is it advised for patients not to take tetracycline and go into the sun?

<p>To prevent drug-induced photosensitivity (A)</p> Signup and view all the answers

What is the reason for taking doxycycline with food?

<p>To reduce the risk of GI irritation (A)</p> Signup and view all the answers

What is the potential result of UV exposure when taking certain medications like tetracyclines?

<p>Photoallergic reactions (D)</p> Signup and view all the answers

What is the potential adverse reaction associated with tetracycline use?

<p>Neurotoxicity (C)</p> Signup and view all the answers

What side effect does doxycycline help mitigate when taken with food?

<p>Epigastric distress (C)</p> Signup and view all the answers

What is the specific combination of immediate and sustained release in ORACEA (doxycycline)?

<p>60% immediate, 40% delayed (B)</p> Signup and view all the answers

Why are tetracyclines not recommended to be taken with antacid or milk?

<p>To prevent coupling with calcium (C)</p> Signup and view all the answers

In what type of glands does tetracycline accumulate?

<p>Sebaceous glands (D)</p> Signup and view all the answers

What is the mechanism by which minocycline may cause pseudotumor?

<p>Cerebrospinal fluid drainage (A)</p> Signup and view all the answers

What is the main effect of prednisolone acetate 1% or fluorometholone when used three times a day for 2-3 weeks, as per the text?

<p>Anti-inflammatory effect (D)</p> Signup and view all the answers

What is the main function of doxycycline in treating recurrent corneal erosion (RCE) according to the text?

<p>Reducing inflammation (A)</p> Signup and view all the answers

Which enzyme is ORACEA primarily targeting?

<p>Matrix metalloproteinase-9 (MMP-9) (C)</p> Signup and view all the answers

What is the incidence of tetracycline-induced pseudotumor cerebri syndrome (PTCS) among 12-50 year olds?

<p>63.9 per 100 person-years (D)</p> Signup and view all the answers

What distinguishes tetracycline-induced pseudotumor cerebri syndrome (PTCS) from idiopathic intracranial hypertension (IIH)?

<p>Onset of signs/symptoms within 30 days of starting the drug (A)</p> Signup and view all the answers

What does the study suggest regarding the incidence of pseudotumor cerebri syndrome (PTCS) among tetracycline users compared to the general population?

<p>Significantly higher incidence than idiopathic intracranial hypertension (IIH) (B)</p> Signup and view all the answers

What are the characteristic symptoms associated with pseudotumor cerebri syndrome (PTCS)?

<p>Headache, transient visual obscurations, pulsatile tinnitus (D)</p> Signup and view all the answers

In which group did the study find tetracycline-induced pseudotumor cerebri syndrome (PTCS) to be more prevalent?

<p>Younger individuals, those more likely to be obese, with shorter duration and lower recurrence (D)</p> Signup and view all the answers

What is the primary distinguishing factor between tetracycline-induced pseudotumor cerebri syndrome (PTCS) and idiopathic intracranial hypertension (IIH) based on the study?

<p>Association based on onset and discontinuation of drug (C)</p> Signup and view all the answers

What is the conclusion regarding the causative link between tetracycline use and pseudotumor cerebri syndrome (PTCS)?

<p>Causative link not firmly established (D)</p> Signup and view all the answers

What are the characteristics of pseudotumor cerebri syndrome (PTCS) according to the study?

<p><strong>Increased</strong> intracranial pressure with normal brain parenchyma, associated headache, transient visual obscurations, diplopia, pulsatile tinnitus (C)</p> Signup and view all the answers

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