Treatment of Recurrent Corneal Erosion (RCE) Quiz
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Questions and Answers

What is the primary adverse effect of tetracycline?

  • Diabetes
  • Intracranial hypertension
  • Discoloration of teeth (correct)
  • Bone growth suppression in adults

    • Why is it not advisable to take tetracycline during pregnancy or in children 8 years or younger?

  • It causes intracranial hypertension
  • It leads to cancer
  • It affects calcium metabolism (correct)
  • It suppresses bone growth in adults

    • What is a potential adverse reaction associated with minocycline use?

  • Intracranial hypertension
  • Pseudotumor cerebri (correct)
  • Decrease in bone growth
  • Transient visual obscurations

    • How long after using minocycline may pseudotumor develop?

    <p>2 months to a year</p> Signup and view all the answers

    What is the mechanism by which minocycline may cause pseudotumor?

    <p>Decrease in cerebrospinal fluid absorption</p> Signup and view all the answers

    What is the recommended treatment for resolving pseudotumor caused by minocycline?

    <p>Discontinuation of the drug</p> Signup and view all the answers

    What is the potential residual effect of pseudotumor induced by minocycline?

    <p>Visual field defect</p> Signup and view all the answers

    What is the primary use of tetracycline?

    <p>Treatment of acne and rosacea</p> Signup and view all the answers

    What is the recommended dosage form for tetracycline?

    <p>250 mg &amp; 500 mg capsules</p> Signup and view all the answers

    Why should tetracycline be taken on an empty stomach?

    <p>To enhance its absorption</p> Signup and view all the answers

    What is the potential issue with tetracycline use during pregnancy and lactation?

    <p>It can cause birth defects</p> Signup and view all the answers

    In what type of glands does tetracycline accumulate?

    <p>Sebaceous glands</p> Signup and view all the answers

    What is the tetracycline of choice for treating chlamydia, acne, and rosacea?

    <p>Doxycycline</p> Signup and view all the answers

    How long is tetracycline typically used for treating certain conditions such as meibomianitis?

    <p>Months</p> Signup and view all the answers

    What is the main function of doxycycline in treating recurrent corneal erosion (RCE) according to the text?

    <p>It reduces the activity of metalloproteinase-9 in the corneal epithelium</p> Signup and view all the answers

    What is the recommended dosage regimen for doxycycline (ORACEA) for treating rosacea?

    <p>40 mg capsule taken once daily in the morning on an empty stomach</p> Signup and view all the answers

    In what condition has the enzyme metalloproteinase-9 been found to be increased, as mentioned in the text?

    <p>Recurrent corneal erosion (RCE)</p> Signup and view all the answers

    What is the main effect of prednisolone acetate 1% or fluorometholone when used three times a day for 2-3 weeks, as per the text?

    <p>It decreases the activity of metalloproteinase-9 in the corneal epithelium</p> Signup and view all the answers

    How is ORACEA (doxycycline) filled with different types of beads, according to the text?

    <p>30mg immediate release and 10mg delayed release beads</p> Signup and view all the answers

    What has been found to help with recurrent corneal erosion (RCE) when caused by a fingernail cut?

    <p>Doxycycline</p> Signup and view all the answers

    What is the effect of doxycycline on the enzyme metalloproteinase-9 in the corneal epithelium, based on the text?

    <p>It decreases the activity of metalloproteinase-9</p> Signup and view all the answers

    What is the purpose of oracea in relation to inflammation and bacteria?

    <p>To decrease the inflammation caused by bacteria</p> Signup and view all the answers

    How does the antibiotic level of regular doxycycline compare to that of oracea?

    <p>Regular doxycycline crosses the antibiotic level threshold more than oracea</p> Signup and view all the answers

    What is the specific combination of immediate and delayed release in oracea?

    <p>40mg immediate release and 10mg delayed release</p> Signup and view all the answers

    Which enzyme is oracea primarily targeting?

    <p>Enzymes involved in inflammation</p> Signup and view all the answers

    What dosage of oracea is recommended for an empty stomach?

    <p>40mg once daily</p> Signup and view all the answers

    In the context of rosacea treatment, how long is the recommended tapering period for regular doxycycline?

    <p>2 weeks</p> Signup and view all the answers

    Which other antibiotic is mentioned as a treatment option for rosacea?

    <p>Erythromycin</p> Signup and view all the answers

    What is the primary mechanism of action of tetracycline?

    <p>Inhibition of protein synthesis</p> Signup and view all the answers

    Which type of bacteria does tetracycline have activity against?

    <p>Gram-positive and Gram-negative bacteria</p> Signup and view all the answers

    What is the role of tetracycline in the treatment of Chlamydia?

    <p>It interferes with protein synthesis</p> Signup and view all the answers

    Why is resistance developed towards Staphylococcus aureus (S. aureus) for tetracycline?

    <p>Increased efflux pumps</p> Signup and view all the answers

    What is the characteristic feature of tetracycline's activity on lipase production?

    <p>Inhibition of lipase production</p> Signup and view all the answers

    What condition is related to the anticollagenolytic activity of systemic tetracycline?

    <p>Corneal ulcers</p> Signup and view all the answers

    Why is it recommended to take tetracyclines without food?

    <p>To ensure higher concentration in the system</p> Signup and view all the answers

    Which tetracycline is the exception and can be taken with food?

    <p>Doxycycline</p> Signup and view all the answers

    What precaution should be taken after a patient takes doxycycline to avoid epigastric distress?

    <p>Avoid lying down for at least 30 minutes</p> Signup and view all the answers

    Why is it advised for patients not to take tetracycline and go into the sun?

    <p>To prevent drug-induced photosensitivity</p> Signup and view all the answers

    What is the reason for taking doxycycline with food?

    <p>To reduce the risk of GI irritation</p> Signup and view all the answers

    What is the potential result of UV exposure when taking certain medications like tetracyclines?

    <p>Photoallergic reactions</p> Signup and view all the answers

    What is the potential adverse reaction associated with tetracycline use?

    <p>Neurotoxicity</p> Signup and view all the answers

    What side effect does doxycycline help mitigate when taken with food?

    <p>Epigastric distress</p> Signup and view all the answers

    What is the specific combination of immediate and sustained release in ORACEA (doxycycline)?

    <p>60% immediate, 40% delayed</p> Signup and view all the answers

    Why are tetracyclines not recommended to be taken with antacid or milk?

    <p>To prevent coupling with calcium</p> Signup and view all the answers

    In what type of glands does tetracycline accumulate?

    <p>Sebaceous glands</p> Signup and view all the answers

    What is the mechanism by which minocycline may cause pseudotumor?

    <p>Cerebrospinal fluid drainage</p> Signup and view all the answers

    What is the main effect of prednisolone acetate 1% or fluorometholone when used three times a day for 2-3 weeks, as per the text?

    <p>Anti-inflammatory effect</p> Signup and view all the answers

    What is the main function of doxycycline in treating recurrent corneal erosion (RCE) according to the text?

    <p>Reducing inflammation</p> Signup and view all the answers

    Which enzyme is ORACEA primarily targeting?

    <p>Matrix metalloproteinase-9 (MMP-9)</p> Signup and view all the answers

    What is the incidence of tetracycline-induced pseudotumor cerebri syndrome (PTCS) among 12-50 year olds?

    <p>63.9 per 100 person-years</p> Signup and view all the answers

    What distinguishes tetracycline-induced pseudotumor cerebri syndrome (PTCS) from idiopathic intracranial hypertension (IIH)?

    <p>Onset of signs/symptoms within 30 days of starting the drug</p> Signup and view all the answers

    What does the study suggest regarding the incidence of pseudotumor cerebri syndrome (PTCS) among tetracycline users compared to the general population?

    <p>Significantly higher incidence than idiopathic intracranial hypertension (IIH)</p> Signup and view all the answers

    What are the characteristic symptoms associated with pseudotumor cerebri syndrome (PTCS)?

    <p>Headache, transient visual obscurations, pulsatile tinnitus</p> Signup and view all the answers

    In which group did the study find tetracycline-induced pseudotumor cerebri syndrome (PTCS) to be more prevalent?

    <p>Younger individuals, those more likely to be obese, with shorter duration and lower recurrence</p> Signup and view all the answers

    What is the primary distinguishing factor between tetracycline-induced pseudotumor cerebri syndrome (PTCS) and idiopathic intracranial hypertension (IIH) based on the study?

    <p>Association based on onset and discontinuation of drug</p> Signup and view all the answers

    What is the conclusion regarding the causative link between tetracycline use and pseudotumor cerebri syndrome (PTCS)?

    <p>Causative link not firmly established</p> Signup and view all the answers

    What are the characteristics of pseudotumor cerebri syndrome (PTCS) according to the study?

    <p><strong>Increased</strong> intracranial pressure with normal brain parenchyma, associated headache, transient visual obscurations, diplopia, pulsatile tinnitus</p> Signup and view all the answers

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