Treatment for Positive Direct Antiglobulin Test (Coomb's Test)
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Questions and Answers

What is the treatment of choice for Paroxysmal Nocturnal Hemoglobinuria?

  • Immunosuppressive therapy if steroids fail (correct)
  • Splenectomy as first-line treatment
  • Blood transfusions with caution
  • High-dose prednisone for a short duration

Which of the following conditions is NOT a mechanical cause of hemolysis similar to paroxysmal nocturnal hemoglobinuria?

  • Microangiopathic hemolytic anemia
  • March hemoglobinuria
  • Valve prosthesis
  • Autoimmune hemolytic anemia (correct)

What is the main clinical manifestation associated with paroxysmal nocturnal hemoglobinuria?

  • Dark urine in the morning (correct)
  • Thrombocytopenia
  • Jaundice
  • Hematuria

Which of the following is a major role of the liver in managing hemolysis?

<p>Removing Hb bound to haptoglobin (C)</p> Signup and view all the answers

What is the mechanism through which renal tubular cells process hemoglobin in paroxysmal nocturnal hemoglobinuria?

<p>Breaks it down and deposits hemosiderin in cells (A)</p> Signup and view all the answers

What is the pathogenesis of Paroxysmal Nocturnal Hemoglobinuria?

<p>Stem cell disorder leading to abnormal red cells, white cells, and platelets (B)</p> Signup and view all the answers

What characterizes the red cells in Paroxysmal Nocturnal Hemoglobinuria?

<p>Membrane defect rendering them sensitive to lysis by complement (B)</p> Signup and view all the answers

Why is splenectomy sometimes performed in Paroxysmal Nocturnal Hemoglobinuria cases?

<p>To remove a site where antibody-coated red blood cells are destroyed (B)</p> Signup and view all the answers

Which second-line treatment option is mentioned for Paroxysmal Nocturnal Hemoglobinuria?

<p>Rituximab (A)</p> Signup and view all the answers

What distinguishes paroxysmal nocturnal hemoglobinuria from autoimmune hemolytic anemia?

<p>Absence of dark urine in the morning (D)</p> Signup and view all the answers

Which of the following is a common symptom seen in paroxysmal nocturnal hemoglobinuria patients?

<p>Fatigue and shortness of breath (D)</p> Signup and view all the answers

What is the consequence of red cell membrane defect in Paroxysmal Nocturnal Hemoglobinuria?

<p>Increased sensitivity to lysis by complement (C)</p> Signup and view all the answers

What are the manifestations of hemolysis in patients with paroxysmal nocturnal hemoglobinuria?

<p>Hepatosplenomegaly and pigment gallstones (A)</p> Signup and view all the answers

Which symptom is not associated with paroxysmal nocturnal hemoglobinuria?

<p>Impaired growth in children (A)</p> Signup and view all the answers

What sign may be observed in patients with paroxysmal nocturnal hemoglobinuria due to hyperdynamic circulation?

<p>Tachycardia and signs of big pulse pressure (A)</p> Signup and view all the answers

Which symptom is a potential sign of heart failure in severe cases of paroxysmal nocturnal hemoglobinuria?

<p>Exertional dyspnea and palpitations (C)</p> Signup and view all the answers

What might indicate the presence of high output heart failure in a patient with paroxysmal nocturnal hemoglobinuria?

<p>Accentuated heart sounds and third heart sound (D)</p> Signup and view all the answers

Which clinical manifestation is not typically associated with paroxysmal nocturnal hemoglobinuria?

<p>Impotence (B)</p> Signup and view all the answers

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