Podcast
Questions and Answers
What is the primary function of channels in transport proteins?
What is the primary function of channels in transport proteins?
- Use ATP to transport substances against their gradient
- Bind to substances and change their conformation
- Provide a barrier to prevent ion flow
- Facilitate the diffusion of specific ions (correct)
Which type of channel is opened by mechanical stimuli?
Which type of channel is opened by mechanical stimuli?
- Mechanically-gated channels (correct)
- Ligand-gated channels
- Second messenger gated channels
- Voltage-gated channels
How do pumps differ from carriers in terms of energy use?
How do pumps differ from carriers in terms of energy use?
- Both use energy but pumps are specific to ions only
- Pumps rely on hydrolysis of ATP for transport, while carriers do not (correct)
- Carriers can use ATP indirectly while pumps cannot
- Pumps do not require energy, carriers do
What defines a uniport transporter?
What defines a uniport transporter?
What is the function of a symport transport mechanism?
What is the function of a symport transport mechanism?
What role does the sodium-potassium pump play in cellular function?
What role does the sodium-potassium pump play in cellular function?
Which statement about antiporters is true?
Which statement about antiporters is true?
What distinguishes ligand-gated channels from other types of channels?
What distinguishes ligand-gated channels from other types of channels?
What term describes the RNA that is synthesized and immediately undergoes processing before being released into the cytoplasm?
What term describes the RNA that is synthesized and immediately undergoes processing before being released into the cytoplasm?
Which process involves the conversion of the linear sequence of codons on mRNA into a polypeptide chain?
Which process involves the conversion of the linear sequence of codons on mRNA into a polypeptide chain?
What is the role of tRNA in the translation process?
What is the role of tRNA in the translation process?
Which of the following statements accurately describes the concept of normalcy in biological systems?
Which of the following statements accurately describes the concept of normalcy in biological systems?
What is the significance of post-translational modification in protein synthesis?
What is the significance of post-translational modification in protein synthesis?
What is the approximate percentage of total body water (% TBW) in a normal adult woman?
What is the approximate percentage of total body water (% TBW) in a normal adult woman?
Which of the following statements about total body water (TBW) in infants is true?
Which of the following statements about total body water (TBW) in infants is true?
Which of these is the only naturally regulated entry route for extracellular fluid (ECF)?
Which of these is the only naturally regulated entry route for extracellular fluid (ECF)?
How is the distribution of extracellular fluid (ECF) divided?
How is the distribution of extracellular fluid (ECF) divided?
What is the approximate lean (fat-free) body mass for a normal adult man?
What is the approximate lean (fat-free) body mass for a normal adult man?
What is the primary difference between osmolarity and osmolality?
What is the primary difference between osmolarity and osmolality?
At a pH of 7.4, what is the concentration of H+ ions in the body fluids?
At a pH of 7.4, what is the concentration of H+ ions in the body fluids?
What is a primary function of cell adhesion molecules (CAMs)?
What is a primary function of cell adhesion molecules (CAMs)?
How does the intracellular compartment's osmolality compare to that of the extracellular compartment?
How does the intracellular compartment's osmolality compare to that of the extracellular compartment?
Which type of junction is responsible for the selective permeability in epithelial tissues?
Which type of junction is responsible for the selective permeability in epithelial tissues?
Which of the following families do not belong to the classifications of CAMs?
Which of the following families do not belong to the classifications of CAMs?
Which statement correctly describes a factor affecting osmolarity?
Which statement correctly describes a factor affecting osmolarity?
What effect would a breakdown of the body's homeostatic mechanisms most likely indicate?
What effect would a breakdown of the body's homeostatic mechanisms most likely indicate?
What critical role do CAMs play in inflammation?
What critical role do CAMs play in inflammation?
What is the primary function of receptors in the cell membrane?
What is the primary function of receptors in the cell membrane?
In the context of the cell membrane, what does endocytosis refer to?
In the context of the cell membrane, what does endocytosis refer to?
Which types of junctions primarily contribute to the mechanical strength of tissues?
Which types of junctions primarily contribute to the mechanical strength of tissues?
Which function is not associated with exocytosis?
Which function is not associated with exocytosis?
What is the primary function of microfilaments in the cell?
What is the primary function of microfilaments in the cell?
Which molecular motor is primarily responsible for transporting substances toward the cell's nucleus?
Which molecular motor is primarily responsible for transporting substances toward the cell's nucleus?
What do vaults primarily do within the cell?
What do vaults primarily do within the cell?
What structural role do intermediate filaments play in cells?
What structural role do intermediate filaments play in cells?
What component of the cell is responsible for carrying genetic information?
What component of the cell is responsible for carrying genetic information?
How do kinesin and dynein differ in their function within the cell?
How do kinesin and dynein differ in their function within the cell?
What structure forms the mitotic spindle to move chromosomes during cell division?
What structure forms the mitotic spindle to move chromosomes during cell division?
What function does the nuclear membrane perform regarding molecular transport?
What function does the nuclear membrane perform regarding molecular transport?
Flashcards
Integral (transmembrane) proteins
Integral (transmembrane) proteins
Proteins embedded within the cell membrane that facilitate the movement of molecules across the membrane.
Channels
Channels
A type of integral protein that forms a channel through the cell membrane, allowing specific ions to passively diffuse across the membrane.
Voltage-gated channels
Voltage-gated channels
Channels that can be opened or closed in response to changes in the electrical potential across the cell membrane.
Ligand-gated channels
Ligand-gated channels
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Second messenger gated channels
Second messenger gated channels
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Carriers
Carriers
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Facilitated diffusion carriers
Facilitated diffusion carriers
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Pumps
Pumps
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Cytoskeleton
Cytoskeleton
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Vaults
Vaults
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Microtubules
Microtubules
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Microfilaments
Microfilaments
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Molecular Motors
Molecular Motors
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Mitotic Spindle
Mitotic Spindle
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Nuclear Membrane (Envelope)
Nuclear Membrane (Envelope)
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Chromatin
Chromatin
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Cell membrane receptors
Cell membrane receptors
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Cell membrane enzymes
Cell membrane enzymes
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Cell membrane antigens
Cell membrane antigens
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Cell Adhesion Molecules (CAMs)
Cell Adhesion Molecules (CAMs)
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Tight junction (zonula occludens)
Tight junction (zonula occludens)
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Endocytosis
Endocytosis
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Exocytosis
Exocytosis
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Adherens junctions
Adherens junctions
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Transcription
Transcription
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Post-transcriptional modification
Post-transcriptional modification
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Translation
Translation
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Post-translational modification
Post-translational modification
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Osmolarity
Osmolarity
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Osmolality
Osmolality
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pH
pH
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Osmotic Pressure
Osmotic Pressure
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Homeostasis
Homeostasis
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Body water percentage
Body water percentage
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Extracellular fluid (ECF)
Extracellular fluid (ECF)
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Intracellular fluid (ICF)
Intracellular fluid (ICF)
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ECF exit routes and regulation
ECF exit routes and regulation
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Fluid compartment interactions
Fluid compartment interactions
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Study Notes
Chapter 1: Cell Physiology
- Cell structure and functions are fundamental to life
- Body fluid compartments and their composition are crucial aspects of physiology
- External and internal environments are in dynamic interaction
- Changes in temperature, pH, and osmotic pressure affect cell activity
Cell Structure and Function
- Cells are composed of water (70-80%), electrolytes (cations like K+, Na+, Mg++, anions like HCO₃⁻, PO₄³⁻), proteins (10-20%), lipids, and carbohydrates (10%)
- Organelles are specialized structures within the cell
- Membranous organelles include cell membrane, endoplasmic reticulum, mitochondria, Golgi apparatus, lysosomes, and peroxisomes.
- Nonmembranous organelles include ribosomes, centrioles, vaults, microtubules, microfilaments
- Nuclear membranous organelles include nuclear membrane (envelope), and nuclear nonmembranous include chromatin and nucleolus.
- Inclusion bodies are temporary structures in cytoplasm (lipid droplets, glycogen granules, secretory granules).
Cell Membrane
- The cell membrane (plasma membrane) is a dynamic, semi-permeable structure (7.5-10 nm thick)- a lipid bilayer with embedded proteins.
- The bilayer has hydrophilic (polar) phosphate heads facing the aqueous environments and hydrophobic (nonpolar) fatty acid tails facing each other.
- Integral proteins are embedded within the membrane or extending through both leaflets
- Peripheral proteins are associated with the membrane surface, often bound to integral proteins.
Cytoplasmic Membranous Organelles
- Golgi apparatus, rough endoplasmic reticulum, smooth endoplasmic reticulum, mitochondria, lysosomes are discussed.
Cytoplasmic Non-Membranous Organelles
- Ribosomes, centrioles, microtubules and microfilaments are discussed
Functions of Cell Membrane
- The cell membrane exhibits permeability and plays a role in movement of substances into and out of cells.
- Membrane proteins act as channels and carriers, facilitating ion and molecule transport.
- Channels permit passive diffusion through the membrane
- Carriers bind substances and change shape to move them through.
- Pumps actively move substances against their concentration gradient, requiring energy.
Cell Membrane Protein Types
- Integral proteins are embedded within the membrane
- Peripheral proteins are located on the membrane surface
Cell Adhesion Molecules (CAMs)
- CAMs are proteins attaching cells to each other and the extracellular matrix.
- Essential for tissue structure and function.
Intercellular Junctions
- Tight junctions (zonula occludens) firmly bind cells, preventing leakage.
- Desmosomes (spot-like) strengthen tissues
- Gap junctions facilitate rapid transfer of ions and molecules between adjacent cells.
Endoplasmic Reticulum
- Smooth ER synthesis of lipids and steroids, detoxification
- Rough ER protein synthesis (ribosomes attached)
Golgi Apparatus
- Involved in modifying, sorting, and packaging proteins and lipids for secretion or use within the cell.
Lysosomes
- Contain digestive enzymes for waste breakdown and recycling.
Mitochondria
- Site of energy production (ATP) through cellular respiration.
- Contain their own DNA (mtDNA).
Nucleus
- Contains genetic material (DNA) organized into chromosomes.
- Nuclear envelope separates the nucleus from the cytoplasm.
- Nucleolus is the site of ribosome synthesis.
Normal Values
- Various physiological values (e.g., heart rate, body composition) vary based on individual factors (sex, age, body mass)
- Wide ranges are often considered normal.
Total Body Water (TBW)
- Percentage of TBW varies depending on age, sex, and body fat.
- Infants have a high percentage of TBW compared to adults.
Body Fluid Compartments
- Extracellular fluid (ECF) surrounds the cells.
- Intracellular fluid (ICF) is inside cells.
- Interstitial fluid (ISF) is a type of ECF.
- Plasma is the fluid of blood.
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