Transdermal Drug Products Quiz

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What is the fundamental principle of transdermal drug delivery?

The drug passes through the stratum corneum and deeper skin layers (correct)
The drug is absorbed through the gastrointestinal system
The drug is applied onto intact and healthy skin
The drug accumulates in the dermal layer

What is a key advantage of transdermal drug products?

They require frequent dosing
They are administered in an inconsistent manner
They bypass the first-pass metabolism of the liver (correct)
They primarily affect the gastrointestinal system

How does the stimulatory G protein (Gs) affect adenylyl cyclase activity?

It activates adenylyl cyclase to decrease intracellular cAMP
It activates adenylyl cyclase to increase intracellular cAMP (correct)
It inhibits adenylyl cyclase to decrease intracellular cAMP
It has no effect on adenylyl cyclase activity

What is the function of inhibitory G protein (Gi) on adenylyl cyclase activity?

It inhibits adenylyl cyclase to decrease intracellular cAMP (D) Signup and view all the answers

What is the primary effect of transdermal drugs on dosing frequencies?

They decrease dosing frequencies (B) Signup and view all the answers

How do transdermal drugs affect the risk of damage to the gastrointestinal system?

They bypass the gastrointestinal system (D) Signup and view all the answers

Where does a drug accumulate when applied as a transdermal patch?

In the systemic circulation (B) Signup and view all the answers

What is the primary route of drug absorption in transdermal drug delivery?

Dermal microcirculation (C) Signup and view all the answers

What is the effect of transdermal drugs on consistent patient use?

They increase the likelihood of consistent patient use (A) Signup and view all the answers

What is tachyphylaxis?

An acute decrease in response to a drug after its administration (D) Signup and view all the answers

What can contribute to regulation of receptor function and distribution?

Receptor phosphorylation-reduction and arrestin-mediated receptor internalization (A) Signup and view all the answers

What occurs following agonist binding to a G-protein coupled receptor?

Receptor phosphorylation-reduction in cellular response and arrestin-mediated receptor internalization (B) Signup and view all the answers

What is drug tolerance defined as?

A reduced pharmacologic response following continuing drug administration relative to the magnitude of response observed after the first dose (C) Signup and view all the answers

What can be the consequence of long-term agonist exposure on receptors?

Receptor down-regulation (D) Signup and view all the answers

What can be the consequence of long-term antagonist exposure on receptors?

Receptor up-regulation (B) Signup and view all the answers

What triggers reduction in receptor synthesis rates?

Long-term agonist exposure (A) Signup and view all the answers

What triggers an increase in receptor synthesis rates?

Long-term antagonist exposure (D) Signup and view all the answers

What contributes to observed drug tolerance collectively?

Receptor phosphorylation, reduction in cellular response, arrestin-mediated receptor internalization, receptor down-regulation, and receptor up-regulation (B) Signup and view all the answers