Transdermal Drug Products Quiz
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Questions and Answers

What is the fundamental principle of transdermal drug delivery?

  • The drug passes through the stratum corneum and deeper skin layers (correct)
  • The drug is absorbed through the gastrointestinal system
  • The drug is applied onto intact and healthy skin
  • The drug accumulates in the dermal layer

    • What is a key advantage of transdermal drug products?

  • They require frequent dosing
  • They are administered in an inconsistent manner
  • They bypass the first-pass metabolism of the liver (correct)
  • They primarily affect the gastrointestinal system

    • How does the stimulatory G protein (Gs) affect adenylyl cyclase activity?

  • It activates adenylyl cyclase to decrease intracellular cAMP
  • It activates adenylyl cyclase to increase intracellular cAMP (correct)
  • It inhibits adenylyl cyclase to decrease intracellular cAMP
  • It has no effect on adenylyl cyclase activity

    • What is the function of inhibitory G protein (Gi) on adenylyl cyclase activity?

    <p>It inhibits adenylyl cyclase to decrease intracellular cAMP</p> Signup and view all the answers

    What is the primary effect of transdermal drugs on dosing frequencies?

    <p>They decrease dosing frequencies</p> Signup and view all the answers

    How do transdermal drugs affect the risk of damage to the gastrointestinal system?

    <p>They bypass the gastrointestinal system</p> Signup and view all the answers

    Where does a drug accumulate when applied as a transdermal patch?

    <p>In the systemic circulation</p> Signup and view all the answers

    What is the primary route of drug absorption in transdermal drug delivery?

    <p>Dermal microcirculation</p> Signup and view all the answers

    What is the effect of transdermal drugs on consistent patient use?

    <p>They increase the likelihood of consistent patient use</p> Signup and view all the answers

    What is tachyphylaxis?

    <p>An acute decrease in response to a drug after its administration</p> Signup and view all the answers

    What can contribute to regulation of receptor function and distribution?

    <p>Receptor phosphorylation-reduction and arrestin-mediated receptor internalization</p> Signup and view all the answers

    What occurs following agonist binding to a G-protein coupled receptor?

    <p>Receptor phosphorylation-reduction in cellular response and arrestin-mediated receptor internalization</p> Signup and view all the answers

    What is drug tolerance defined as?

    <p>A reduced pharmacologic response following continuing drug administration relative to the magnitude of response observed after the first dose</p> Signup and view all the answers

    What can be the consequence of long-term agonist exposure on receptors?

    <p>Receptor down-regulation</p> Signup and view all the answers

    What can be the consequence of long-term antagonist exposure on receptors?

    <p>Receptor up-regulation</p> Signup and view all the answers

    What triggers reduction in receptor synthesis rates?

    <p>Long-term agonist exposure</p> Signup and view all the answers

    What triggers an increase in receptor synthesis rates?

    <p>Long-term antagonist exposure</p> Signup and view all the answers

    What contributes to observed drug tolerance collectively?

    <p>Receptor phosphorylation, reduction in cellular response, arrestin-mediated receptor internalization, receptor down-regulation, and receptor up-regulation</p> Signup and view all the answers

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