Transdermal Drug Delivery Systems: Advantages and Disadvantages
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Questions and Answers

What is the purpose of transdermal drug delivery systems (TDDS)?

  • To release drugs slowly through the skin into the systemic circulation (correct)
  • To inject drugs directly into the bloodstream
  • To deliver drugs via inhalation/aerosol
  • To encapsulate drugs in a polymeric material

    • What distinguishes monolithic transdermal systems from membrane-controlled systems?

  • The lack of control over drug release rate
  • The absence of a polymeric material
  • The presence of a drug matrix layer (correct)
  • The drug being dispersed in the backing layer

    • In a disperse system, what is the continuous phase also known as?

  • Dispersion medium (correct)
  • Dispersed phase
  • External phase
  • Internal phase

    • Which type of system contains insoluble solid particles dispersed in a liquid medium?

    <p>Suspensions</p> Signup and view all the answers

    What is a common feature of pharmaceutical suspensions?

    <p>Uniform distribution of suspensoid in the vehicle</p> Signup and view all the answers

    What is the main difference between an emulsion and a suspension?

    <p>Emulsions involve immiscible liquids, suspensions have soluble components</p> Signup and view all the answers

    Which term is used interchangeably with oleaginous bases?

    <p>Hydrocarbon bases</p> Signup and view all the answers

    What type of bases are difficult to wash off due to water immiscibility?

    <p>Oleaginous bases</p> Signup and view all the answers

    What effect do oleaginous bases have on the skin?

    <p>Emollient effect</p> Signup and view all the answers

    What is the main characteristic of vanishing creams?

    <p>They leave a thin residue after water evaporates</p> Signup and view all the answers

    What characteristic makes oleaginous bases difficult to wash off from the skin?

    <p>Water immiscibility</p> Signup and view all the answers

    What is the major difference between ointment/cream and cream/gel?

    <p>Hydrophilic-lipophilic balance</p> Signup and view all the answers

    What is the primary function of an Unguator?

    <p>Mixing ointments</p> Signup and view all the answers

    What is the ideal outcome for drug delivery in transdermal drug delivery systems?

    <p>Migrate through the skin to the underlying blood supply</p> Signup and view all the answers

    What is the purpose of geometric dilution in pharmacy?

    <p>To combine all portions of powder and bases evenly</p> Signup and view all the answers

    In which type of dosage forms is the skin considered the target organ for drug residence?

    <p>Topical dosage forms</p> Signup and view all the answers

    Which type of system consists of a gel mass with floccules of small distinct particles?

    <p>Magma</p> Signup and view all the answers

    What distinguishes water-removable bases from absorption bases?

    <p>Type of emulsion</p> Signup and view all the answers

    What is the title designation for dry powders intended for suspension in liquid vehicles?

    <p>Dry Powder Mixtures</p> Signup and view all the answers

    How does reducing the particle size in a suspension impact its stability?

    <p>Produces slow, more uniform settling rates</p> Signup and view all the answers

    What happens if particle size is reduced too much in a suspensoid?

    <p>Formation of a cake at the bottom of the container</p> Signup and view all the answers

    What is the purpose of preventing agglomeration of particles in a suspension?

    <p>To avoid cake formation at the bottom</p> Signup and view all the answers

    What type of preparation is designated as 'oral suspension'?

    <p>Prepared suspensions not requiring reconstitution</p> Signup and view all the answers

    Which type of vehicle are drugs unstable in that leads to them being supplied as dry powder mixtures?

    <p>Aqueous vehicles</p> Signup and view all the answers

    Why are certain drugs chemically unstable in solution?

    <p>They are more stable when suspended.</p> Signup and view all the answers

    What dosage form exhibits the highest bioavailability according to the text?

    <p>Solution</p> Signup and view all the answers

    Why is taste masking easier to achieve in suspension than in solution?

    <p>The drug has more contact with taste buds in suspension.</p> Signup and view all the answers

    Why is the liquid form preferred over the solid form for many patients?

    <p>It is easier to swallow and administer various doses.</p> Signup and view all the answers

    How is the disadvantage of a disagreeable taste in solution form overcome?

    <p>By administering undissolved particles in an oral suspension.</p> Signup and view all the answers

    What property does erythromycin estolate possess that makes it suitable for preparing a palatable liquid dosage form?

    <p>Being insoluble in the desired vehicle.</p> Signup and view all the answers

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