Transdermal Drug Delivery Systems: Advantages and Disadvantages

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Questions and Answers

What is the purpose of transdermal drug delivery systems (TDDS)?

  • To release drugs slowly through the skin into the systemic circulation (correct)
  • To inject drugs directly into the bloodstream
  • To deliver drugs via inhalation/aerosol
  • To encapsulate drugs in a polymeric material

What distinguishes monolithic transdermal systems from membrane-controlled systems?

  • The lack of control over drug release rate
  • The absence of a polymeric material
  • The presence of a drug matrix layer (correct)
  • The drug being dispersed in the backing layer

In a disperse system, what is the continuous phase also known as?

  • Dispersion medium (correct)
  • Dispersed phase
  • External phase
  • Internal phase

Which type of system contains insoluble solid particles dispersed in a liquid medium?

<p>Suspensions (C)</p> Signup and view all the answers

What is a common feature of pharmaceutical suspensions?

<p>Uniform distribution of suspensoid in the vehicle (A)</p> Signup and view all the answers

What is the main difference between an emulsion and a suspension?

<p>Emulsions involve immiscible liquids, suspensions have soluble components (D)</p> Signup and view all the answers

Which term is used interchangeably with oleaginous bases?

<p>Hydrocarbon bases (A)</p> Signup and view all the answers

What type of bases are difficult to wash off due to water immiscibility?

<p>Oleaginous bases (B)</p> Signup and view all the answers

What effect do oleaginous bases have on the skin?

<p>Emollient effect (C)</p> Signup and view all the answers

What is the main characteristic of vanishing creams?

<p>They leave a thin residue after water evaporates (B)</p> Signup and view all the answers

What characteristic makes oleaginous bases difficult to wash off from the skin?

<p>Water immiscibility (A)</p> Signup and view all the answers

What is the major difference between ointment/cream and cream/gel?

<p>Hydrophilic-lipophilic balance (D)</p> Signup and view all the answers

What is the primary function of an Unguator?

<p>Mixing ointments (C)</p> Signup and view all the answers

What is the ideal outcome for drug delivery in transdermal drug delivery systems?

<p>Migrate through the skin to the underlying blood supply (B)</p> Signup and view all the answers

What is the purpose of geometric dilution in pharmacy?

<p>To combine all portions of powder and bases evenly (A)</p> Signup and view all the answers

In which type of dosage forms is the skin considered the target organ for drug residence?

<p>Topical dosage forms (D)</p> Signup and view all the answers

Which type of system consists of a gel mass with floccules of small distinct particles?

<p>Magma (C)</p> Signup and view all the answers

What distinguishes water-removable bases from absorption bases?

<p>Type of emulsion (D)</p> Signup and view all the answers

What is the title designation for dry powders intended for suspension in liquid vehicles?

<p>Dry Powder Mixtures (C)</p> Signup and view all the answers

How does reducing the particle size in a suspension impact its stability?

<p>Produces slow, more uniform settling rates (D)</p> Signup and view all the answers

What happens if particle size is reduced too much in a suspensoid?

<p>Formation of a cake at the bottom of the container (C)</p> Signup and view all the answers

What is the purpose of preventing agglomeration of particles in a suspension?

<p>To avoid cake formation at the bottom (A)</p> Signup and view all the answers

What type of preparation is designated as 'oral suspension'?

<p>Prepared suspensions not requiring reconstitution (D)</p> Signup and view all the answers

Which type of vehicle are drugs unstable in that leads to them being supplied as dry powder mixtures?

<p>Aqueous vehicles (B)</p> Signup and view all the answers

Why are certain drugs chemically unstable in solution?

<p>They are more stable when suspended. (A)</p> Signup and view all the answers

What dosage form exhibits the highest bioavailability according to the text?

<p>Solution (B)</p> Signup and view all the answers

Why is taste masking easier to achieve in suspension than in solution?

<p>The drug has more contact with taste buds in suspension. (C)</p> Signup and view all the answers

Why is the liquid form preferred over the solid form for many patients?

<p>It is easier to swallow and administer various doses. (C)</p> Signup and view all the answers

How is the disadvantage of a disagreeable taste in solution form overcome?

<p>By administering undissolved particles in an oral suspension. (D)</p> Signup and view all the answers

What property does erythromycin estolate possess that makes it suitable for preparing a palatable liquid dosage form?

<p>Being insoluble in the desired vehicle. (A)</p> Signup and view all the answers

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