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Questions and Answers
What is the primary function of the transamination reaction in metabolism?
What is the primary function of the transamination reaction in metabolism?
- Oxidation of ketoacids directly for energy
- Synthesis and degradation of amino acids (correct)
- Oxidation of amino acids
- Synthesis of erythrocytes
Which tissue contains the highest concentration of AST?
Which tissue contains the highest concentration of AST?
- Kidney
- Cardiac tissue (correct)
- Skeletal muscle
- Pancreas
What is the normal level of serum ALT in IU/L?
What is the normal level of serum ALT in IU/L?
- 30 IU/L
- 20 IU/L
- 10 IU/L
- 15 IU/L (correct)
Which enzyme is primarily used for early detection of liver disease?
Which enzyme is primarily used for early detection of liver disease?
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Where are the smallest amounts of GPT (ALT) found in the body?
Where are the smallest amounts of GPT (ALT) found in the body?
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What role does the tricarboxylic acid cycle play in relation to ketoacids formed by transamination?
What role does the tricarboxylic acid cycle play in relation to ketoacids formed by transamination?
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Study Notes
The Transamination Reaction
- The transamination reaction plays a crucial role in intermediary metabolism, facilitating the synthesis and degradation of amino acids.
- The reaction produces ketoacids, which are ultimately oxidized by the tricarboxylic acid cycle to provide a source of energy.
Tissue Source of AST
- AST is widely distributed in human tissue.
- The highest concentrations of AST are found in cardiac tissue, liver, and skeletal muscle.
- Smaller amounts of AST are found in the kidney, pancreas, and erythrocytes.
Clinical Significance
- Normal serum AST levels are up to 20 IU/L.
- Normal serum ALT levels are up to 15 IU/L.
- ALT (GPT) is primarily found in liver and kidney cells, with smaller amounts in the heart and muscles.
- Normally, ALT levels in blood are low, but when the liver is damaged, ALT is released into the blood, causing levels to increase.
- The ALT blood test is useful for early detection of liver disease.
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Description
Learn about the transamination reaction, its role in amino acid synthesis and degradation, and its significance in intermediary metabolism.
