TPGS Pharmaceutical and Nutraceutical Uses Quiz
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Questions and Answers

What is the main benefit of high-grade TPGS in pharmaceutical and nutraceutical industries?

  • Improving taste of medications
  • Reducing manufacturing costs
  • Enhancing absorption of health-transforming ingredients (correct)
  • Increasing shelf life of products
  • Why does Quicksilver Scientific use high-grade TPGS as a PEG source despite its higher cost?

  • To extend product shelf life
  • To enhance the absorption of ingredients (correct)
  • To reduce manufacturing time
  • To improve drug taste
  • In what condition did d-α-tocopheryl polyethylene glycol-1000 succinate show enhanced absorption of vitamin D?

  • Chronic cholestatic liver disease (correct)
  • Chronic kidney disease
  • Diabetes mellitus
  • Hyperthyroidism
  • What distinguishes the cost of high-grade TPGS from other commercial PEG types?

    <p>High-grade TPGS is 5-10 times more expensive</p> Signup and view all the answers

    What is the main function of d-alpha-tocopheryl polyethylene glycol-1000 succinate in treating vitamin E deficiency during childhood cholestasis?

    <p>To increase the absorption of vitamin E</p> Signup and view all the answers

    Why are lipid vesicles used in drug delivery systems?

    <p>To protect substances from degradation by gastric juices.</p> Signup and view all the answers

    What is a key advantage of lipid nanoparticle delivery systems?

    <p>They improve absorption of substances with poor bioavailability.</p> Signup and view all the answers

    How do liposomal delivery systems enhance the delivery of glutathione?

    <p>By protecting it from breakdown in the digestive system.</p> Signup and view all the answers

    What is the role of optimally-sized liposomes in drug delivery systems?

    <p>To prolong the time the therapeutic core remains in circulation.</p> Signup and view all the answers

    Why are liposomal delivery systems ideal for delivering substances with a prolonged systemic effect?

    <p>Because they protect substances from degradation in gastric juices.</p> Signup and view all the answers

    What is a common symptom associated with consumption of meals high in fat?

    <p>Generalized itching</p> Signup and view all the answers

    When are symptoms of pruritis in cholestasis typically worse in women?

    <p>Before sleep or at night</p> Signup and view all the answers

    What additional symptoms may a person with cholestasis experience due to liver 'backfire'?

    <p>Fatigue and impaired memory</p> Signup and view all the answers

    Which condition in pregnant women should prompt consultation with a physician before using a product?

    <p>Cholestasis</p> Signup and view all the answers

    What type of symptoms may suggest the presence of primary biliary cholangitis?

    <p>Fatigue and itching</p> Signup and view all the answers

    Which gastrointestinal symptom is suggestive of cholestasis related to biliary obstruction?

    <p>Epigastric tenderness</p> Signup and view all the answers

    What adaptation occurs in the intestines due to biliary obstruction?

    <p>Decreased reabsorption of bile acids</p> Signup and view all the answers

    In cholestasis, what may indicate evidence of gross fat malabsorption?

    <p>Stool changes suggesting fat malabsorption</p> Signup and view all the answers

    Which clinical condition may lead to cholestasis?

    <p>Chronic viral hepatitis</p> Signup and view all the answers

    What symptom may be suggestive of primary biliary cholangitis?

    <p>Right upper quadrant pain or tenderness</p> Signup and view all the answers

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