Podcast
Questions and Answers
What is the outcome when the ultimate toxicant reacts with a host molecule, cell or tissue?
What is the outcome when the ultimate toxicant reacts with a host molecule, cell or tissue?
- Immune response
- Cellular repair
- Enzymatic stimulation
- Toxic injury (correct)
What type of compound is most likely to participate in covalent binding with a toxicant?
What type of compound is most likely to participate in covalent binding with a toxicant?
- Lipophilic
- Nucleophilic (correct)
- Electrophilic
- Hydrophobic
What is the result of covalent binding between a toxicant and a target molecule?
What is the result of covalent binding between a toxicant and a target molecule?
- An adduct (correct)
- A noncovalent interaction
- An enzyme-substrate complex
- A reversible bond
What is a potential consequence of covalent binding of toxicants to cellular proteins?
What is a potential consequence of covalent binding of toxicants to cellular proteins?
What type of interaction between toxicants and their targets involves the transfer of electrons?
What type of interaction between toxicants and their targets involves the transfer of electrons?
What is a characteristic of electrophilic compounds?
What is a characteristic of electrophilic compounds?
What is the result of covalent binding of toxicants to phospholipids?
What is the result of covalent binding of toxicants to phospholipids?
What is a characteristic of an endogenous molecule that makes it a target for toxicants?
What is a characteristic of an endogenous molecule that makes it a target for toxicants?
What is a common target for reactive metabolites?
What is a common target for reactive metabolites?
What is the basis for the antithyroid effect of some nucleophilic xenobiotics?
What is the basis for the antithyroid effect of some nucleophilic xenobiotics?
What is required to conclusively identify a target molecule as being responsible for toxicity?
What is required to conclusively identify a target molecule as being responsible for toxicity?
What is the effect of some xenobiotics on neurotransmitter receptors?
What is the effect of some xenobiotics on neurotransmitter receptors?
