25 Questions
After a certain amount of units, which organs are damaged?
Liver, myocardium, and endocrine glands
At what point do organ damages occur in adults?
After 50 units
What is true about the amount of units in children compared to adults?
Children have a lesser amount of units
What type of glands are damaged?
Endocrine glands
What is the order of organ damage?
Liver, myocardium, endocrine glands
What is the platelet count threshold for considering platelet transfusion?
100,000 /µL
Why might platelet transfusion be necessary?
To prevent bleeding
In which situation might platelet transfusion be required?
Before surgical intervention
What is a potential consequence of a low platelet count?
Increased risk of bleeding
When might platelet transfusion be considered?
If there is bleeding or surgical intervention
What is the primary goal of aggressive early replacement in massive blood transfusion?
To maintain normal tissue perfusion
What is the consequence of too little blood transfusion too late?
Far more serious consequences than massive blood transfusion itself
Why is aggressive early replacement essential in massive blood transfusion?
To maintain normal tissue perfusion and prevent development of coagulopathy or thrombocytopenia
What is the result of inadequate blood transfusion?
Far more serious consequences than massive blood transfusion itself
What is the main consideration in massive blood transfusion?
To replace blood loss quickly and adequately
What is the percentage of bacterial contamination in Packed RBC units according to a local study?
9%
What is commonly found in the soil?
Bacterial contamination
What is Bacillus subtilis considered to be?
Not pathogenic or toxic to humans
What type of study is mentioned in the content?
Local study
What is packed in Packed RBC units?
Red blood cells
What is one of the causes of post transfusion hepatitis?
Hepatitis viruses (A, B, C)
Which of the following viruses is not a cause of post transfusion hepatitis?
Rabies virus
What is a common cause of post transfusion hepatitis, besides hepatitis viruses?
Cytomegalovirus (CMV)
Which of the following is a cause of post transfusion hepatitis?
Epstein-Bar virus (EBV)
What is a cause of post transfusion hepatitis, which is not a type of hepatitis virus?
Cytomegalovirus (CMV)
Study Notes
Blood Transfusion and Complications
- After 50 units in adults, and a lesser amount in children, the liver, myocardium, and endocrine glands are damaged.
Platelet Transfusion
- Platelet transfusion is given when platelet count falls below 100,000/µL, especially in cases of bleeding or surgical intervention.
Bacterial Contamination in Packed RBC Units
- Bacterial contamination in packed RBC units is a common issue, with a local study showing a 9% contamination rate.
- Bacillus subtilis, a contaminant, is not pathogenic or toxigenic to humans.
Massive Blood Transfusion
- The most important consideration in massive blood transfusion is to replace blood loss quickly and adequately to maintain normal tissue perfusion and prevent coagulopathy or thrombocytopenia.
Complications of Blood Transfusion
- Delayed or inadequate blood transfusion can have more severe consequences than the transfusion itself.
- Post-transfusion hepatitis can be caused by:
- Hepatitis viruses (A, B, C)
- Cytomegalovirus (CMV)
- Epstein-Barr virus (EBV)
This quiz assesses your understanding of the effects of substance abuse on the human body. Specifically, it explores the damage caused to the liver, myocardium, and endocrine glands after a certain amount of units in adults and children.
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