Toxicology: Carbon Monoxide Poisoning Treatment

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Why is the Po2 of blood normal in Co poisoning despite reduced O2 content?

Since O2 is readily available in the lungs

What is the primary effect of administering pure O2 in Co poisoning?

It rapidly displaces CO from hemoglobin

What is the effect of combining O2 with hemoglobin in the lungs?

It makes hemoglobin more acidic

What is the purpose of administering 5 percent CO2 in Co poisoning therapy?

To strongly stimulate the respiratory center

What is the effect of acidic hemoglobin on its ability to combine with CO2?

It decreases the affinity of hemoglobin for CO2

Study Notes

Carbon Monoxide Poisoning

  • O2 content of blood is greatly reduced in CO poisoning, but Po2 of blood may still be normal
  • CO poisoning can be treated with oxygen therapy, which can displace CO rapidly

Oxygen Therapy

  • Administration of pure O2 can displace CO rapidly
  • Adding 5% CO2 to oxygen therapy strongly stimulates the respiratory center

Hemoglobin and CO2

  • When oxygen combines with hemoglobin in the lungs, it creates a more acidic environment
  • This highly acidic hemoglobin has a lower tendency to combine with CO2

Learn about the effects of carbon monoxide poisoning on blood oxygen levels and how to treat it with oxygen and CO2 administration. Understand the chemistry behind hemoglobin's interaction with CO2 and O2.

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