Lecture 5

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Questions and Answers

What is the appropriate amount of a topical medication for daily application to the entire face for one month?

  • 80 grams
  • 45 grams
  • 60 grams
  • 30 grams (correct)

Which type of topical medication is generally the most moisturizing?

  • Lotion
  • Gel
  • Ointment (correct)
  • Cream

What should not be assumed about 'hypoallergenic' products?

  • They are formulated with medical supervision.
  • They are guaranteed to be safe for all users. (correct)
  • They are entirely free of irritants.
  • They may still contain fragrances.

When prescribing a topical steroid for a rash covering more than 50% of the body, which size tube is inappropriate for twice daily use for two weeks?

<p>30 grams (C)</p> Signup and view all the answers

Which vehicle is described as having no oil and is considered drying?

<p>Gel (A)</p> Signup and view all the answers

What is the main function of the long chain molecules in soaps and shampoos?

<p>To bind oily substances and dissolve them in water. (C)</p> Signup and view all the answers

For the most effective moisturizing regimen after bathing, which product is recommended?

<p>Ceramide-based cream (B)</p> Signup and view all the answers

Which type of topical product is described as potentially irritating due to its formulation?

<p>Gel (A)</p> Signup and view all the answers

What undesirable effect can result from chronic use of soap on hair?

<p>Formation of soap scum on hair shafts (B)</p> Signup and view all the answers

What is the primary purpose of conditioners used after shampooing?

<p>To restore sebum lost during shampooing (B)</p> Signup and view all the answers

Which anti-dandruff ingredient is most commonly preferred by patients?

<p>Zinc pyrithione (C)</p> Signup and view all the answers

What is the recommended practice for daily bathing in patients with dry skin?

<p>Wash only the face, groin, and axillary areas with soap (B)</p> Signup and view all the answers

What potential issue is associated with the continued use of antibacterial soaps?

<p>Development of bacterial resistance (D)</p> Signup and view all the answers

What characteristic distinguishes facial cleansers from regular soaps?

<p>They are less drying and less irritating (B)</p> Signup and view all the answers

What is the main function of sunscreens?

<p>To block ultraviolet radiation (C)</p> Signup and view all the answers

Which type of soap should individuals with dry skin particularly avoid?

<p>Deodorant soaps (D)</p> Signup and view all the answers

How is SPF determined?

<p>By dividing the time in sun necessary to burn with and without the product (D)</p> Signup and view all the answers

What is the primary type of ultraviolet light that SPF measures?

<p>UVB (C)</p> Signup and view all the answers

Which of the following sunscreens is likely to be less irritating to the skin?

<p>One with physical blockers like zinc oxide (D)</p> Signup and view all the answers

What percentage of UVB does an SPF 15 product block?

<p>93.3% (A)</p> Signup and view all the answers

Which of the following statements best describes UVC light?

<p>It does not significantly reach the Earth due to the ozone layer. (D)</p> Signup and view all the answers

What is the minimum SPF recommended for sunscreen use?

<p>15-30 (D)</p> Signup and view all the answers

When should individuals avoid sun exposure for safety?

<p>From 11am to 2pm (D)</p> Signup and view all the answers

Which is NOT a recommendation to enhance sun safety?

<p>Applying sunscreen with chemical blockers only (B)</p> Signup and view all the answers

What is a potential risk associated with the long-term use of topical steroids on the face?

<p>Addiction leading to severe eruptions upon cessation (B)</p> Signup and view all the answers

Which topical steroid is recommended for use on thick skin or severe rashes?

<p>Clobetasol 0.05% ointment (D)</p> Signup and view all the answers

What is a known side effect of using Protopic (tacrolimus)?

<p>Burning sensation upon application (B)</p> Signup and view all the answers

When should 'not daily dosing' be considered when using topical steroids?

<p>If the medication begins to lose effectiveness (B)</p> Signup and view all the answers

What is a key advantage of using Protopic and Elidel compared to topical steroids?

<p>They do not carry a risk of local side effects with chronic use (D)</p> Signup and view all the answers

What should be avoided to reduce the risk of side effects from topical steroids?

<p>Using them for more than two weeks continuously (C)</p> Signup and view all the answers

For which conditions should Protopic and Elidel be primarily reserved?

<p>Facial or groin dermatoses requiring chronic treatment (D)</p> Signup and view all the answers

What is one of the significant long-term risks associated with Protopic and Elidel as per their FDA black-box warning?

<p>Potential for lymphoma development (C)</p> Signup and view all the answers

What is the primary indication for Aldara (imiquimod)?

<p>Genital warts (B)</p> Signup and view all the answers

Which treatment is recommended for severe acne in addition to moderate treatments?

<p>Accutane (D)</p> Signup and view all the answers

What is a suitable treatment option for mild rosacea?

<p>Metronidazole cream (C)</p> Signup and view all the answers

Which regimen is appropriate for treating shampoo-based seborrheic dermatitis?

<p>Head and Shoulders shampoo (C)</p> Signup and view all the answers

What is the first-line treatment for perioral dermatitis?

<p>Clindamycin (D)</p> Signup and view all the answers

What is the correct dosing strategy for prednisone in severe poison ivy cases?

<p>1 mg/kg daily, taper over 3 weeks (C)</p> Signup and view all the answers

Which treatment should be avoided to manage perioral dermatitis?

<p>Topical steroids (B)</p> Signup and view all the answers

What is recommended for xerosis management after showering?

<p>Ceramide-based creams (B)</p> Signup and view all the answers

What is the recommended frequency for applying miconazole or econazole cream for intertrigo?

<p>Twice a day for 2-3 weeks (C)</p> Signup and view all the answers

Which treatment is indicated for thrush?

<p>Mycelex troches (B)</p> Signup and view all the answers

What is the treatment regimen for onychomycosis in non-diabetic patients?

<p>Terbinafine 250 mg QD for 12 weeks (A)</p> Signup and view all the answers

When should patients with zoster be warned about transmissibility?

<p>Even when no lesions are present (B)</p> Signup and view all the answers

What is the preferred treatment for scabies in most cases?

<p>5% Permethrin applied to the entire body (A)</p> Signup and view all the answers

What is the primary method of treating genital warts?

<p>Aldara 3-7 times a week (C)</p> Signup and view all the answers

What instruction should be given regarding treatment for warts after applying Compound W?

<p>Wrap with duct tape overnight (D)</p> Signup and view all the answers

What is the appropriate follow-up treatment for tinea corporis once improvement is noticed?

<p>Reduce to once a week to prevent recurrence (D)</p> Signup and view all the answers

Flashcards

Prescription Amount for Topical Medications

Topical medications are usually packaged in tubes of 30g, 45g, 60g, or 80g. Some generic topical steroids come in 454g (one pound) jars. It's important to prescribe the correct amount to avoid running out before the treatment is complete.

Marketing Terms on Topical Products

Terms like "hypoallergenic", "unscented", and "for sensitive skin" are marketing terms, not medical guarantees. A product labeled as hypoallergenic can still cause allergies, an unscented product might contain fragrance, and a sensitive skin product can irritate.

Moisturizer Types

Ointments are the most moisturizing and greasiest. Creams are less moisturizing and less greasy. Lotions are minimally moisturizing and minimally greasy. Gels and solutions are drying and not greasy.

Best Moisturizing Regimen

Applying a ceramide-based cream or plain petroleum jelly immediately after bathing and before drying off is the most effective way to moisturize.

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Mechanism of Action for Soaps and Shampoos

Soaps and shampoos contain long chain molecules with a hydrophilic (water-loving) end and a hydrophobic (water-fearing) end. This allows them to bind to oily substances and dissolve them in water, but also removes the skin's natural oils, which can be drying.

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Difference Between Soap and Shampoo

Shampoos are specifically formulated to prevent residue build-up on hair shafts.

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Potential Side Effects of Soaps and Shampoos

Soap and shampoo can be inherently drying and slightly irritating to the skin because they strip away natural oils.

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Hypoallergenic Products and Allergies

A common misconception is that "hypoallergenic" dermatological products can't cause allergic reactions, but this is false. Many dermatological products can still cause allergies despite being labeled as hypoallergenic.

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Sun Protection Factor (SPF)

A measure of how well a sunscreen protects skin from sunburn caused by UVB radiation.

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SPF Calculation

The amount of time it takes to get a sunburn while wearing sunscreen compared to the time it takes to get a sunburn without sunscreen.

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UVC

UV light that is absorbed by the ozone layer and does not reach the Earth in significant amounts.

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UVB

UV light that is the main cause of sunburn.

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UVA

UV light that contributes to skin aging and wrinkles.

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Chemical Blockers

Sunscreen ingredients that absorb UV light and convert it to infrared energy (heat).

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Soap Scum on Hair

The build-up of soap residue on hair shafts, similar to 'soap scum' on surfaces.

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Physical Blockers

Sunscreen ingredients that reflect and scatter UV light.

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Purpose of Conditioner

Conditioners are designed to replace natural oils (sebum) removed by shampoos, making hair shiny and manageable.

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Zinc Oxide and Titanium Dioxide

Zinc oxide and titanium dioxide are the two main types of physical blockers, known for their stability and effectiveness in blocking both UVA and UVB radiation.

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Anti-Dandruff Shampoos

Products that contain ingredients like zinc pyrithione, selenium sulfide, or salicylic acid to combat dandruff. They can also help with seborrheic dermatitis.

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Minimizing Soap Use for Dry Skin

Using soap only on areas with higher sweat and oil production (face, groin, armpits) for routine cleaning, while relying on water for the rest of the body.

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Antibacterial Soaps and Resistance

Antibacterial soaps are not proven to be more effective than regular soap and may contribute to bacterial resistance.

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Deodorant Soaps and Dry Skin

Deodorant soaps can be irritating and drying, especially for people with dry skin.

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Facial Cleansers for Sensitive Skin

Facial cleansers are non-lathering and gentler than regular soaps, making them suitable for dry or irritated skin.

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Sunscreens and SPF

Sunscreens, measured by SPF, protect skin from harmful ultraviolet radiation.

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How to use topical steroids safely for a longer period?

Applying topical steroids for longer than two weeks may increase the risk of side effects. To minimize risks, consider using it for two weeks, then taking one week off, or using it Monday to Friday and taking weekends off.

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What can happen if topical steroids are used chronically on the face?

Chronic topical steroid use on the face can lead to skin becoming dependent on the steroid. Stopping steroid use abruptly can cause severe skin reactions.

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Why is the strength of topical steroid important?

Steroids come in different strengths. Choosing the right strength for the area being treated is important for effectiveness and safety.

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What are Protopic and Elidel?

Protopic and Elidel are non-steroid treatments for skin conditions with similar effectiveness to medium-strength steroids. They have a lower risk of typical steroid side effects.

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What is the potential long-term side effect of Protopic and Elidel?

Protopic and Elidel may increase the risk of developing lymphoma, but more research is needed to confirm this.

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When are Protopic and Elidel usually used?

Protopic and Elidel are generally reserved for patients with long-term skin conditions, especially on the face or groin.

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Why are topical steroids often preferred over Protopic and Elidel?

Topical steroids are generally more effective, safer, and cheaper than Protopic and Elidel for most skin conditions. They should be the first choice unless a specific condition requires alternatives.

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What are the potential side effects of topical steroids?

Topical steroids can cause thinning of the skin, stretch marks, broken blood vessels, easy bruising, decreased production of cortisol (a hormone), and eye problems (glaucoma and cataracts) when applied to the eyelids.

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What is Aldara?

Aldara (imiquimod) is a topical medication that stimulates the immune system to fight skin infections. It works by increasing the production of interferon-alpha and other cytokines that help the body fight off viruses and bacteria.

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What is a limitation of Aldara?

Aldara does not penetrate thick skin well, so it may need to be combined with other treatments for conditions like thick warts.

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What are some common uses for Aldara?

Aldara's primary use is for genital warts, but it's also used for actinic keratosis, common warts, and some skin cancers.

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How is mild acne treated?

Mild acne can be treated with topical medications like tretinoin or benzoyl peroxide.

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How is moderate acne treated?

Moderate acne requires a combination of treatments like topical medications, oral antibiotics, and sometimes hormonal therapy.

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What is a treatment option for severe acne?

Severe acne often requires oral medications like Accutane, which can have serious side effects.

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What is a common treatment for rosacea?

Rosacea, a skin condition causing redness and bumps, can be treated with topical medications like metronidazole and avoiding triggers like sun exposure.

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How is seborrheic dermatitis treated?

Seborrheic dermatitis, a condition causing flaky scalp and skin, can be treated with shampoos like Head & Shoulders and topical medications like ketoconazole.

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What is Intertrigo?

A common skin condition characterized by a rash in skin folds, such as under the breasts, the groin, or armpits. This is caused by moisture trapped in these areas, leading to irritation and fungal growth.

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What is oral thrush?

A fungal infection of the mouth, often causing white patches on the tongue and inner cheeks. It's common in individuals with weakened immune systems, like those with diabetes or taking certain medications.

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What is Tinea (Ringworm)?

A fungal infection of the skin, hair, or nails. It can appear as itchy, scaly patches on the body, ringworm-like patterns on the skin, or nail discoloration and thickening.

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What is Onychomycosis?

A fungal infection of the nails, causing discoloration, thickening, and sometimes even separation of the nail from the nail bed. It's more common in individuals with diabetes or weakened immune systems.

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What is Shingles?

A viral infection that causes a painful rash with blisters, typically on one side of the body. It's caused by the varicella-zoster virus, the same virus that causes chickenpox.

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What is Herpes?

A viral infection that causes sores on the lips or genitals. It's caused by the herpes simplex virus (HSV).

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What is Molluscum Contagiosum?

A very common skin condition caused by a virus, producing small, flesh-colored, dome-shaped bumps. It's often spread through close contact or sharing towels.

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What are Warts?

A common skin condition caused by a virus, which leads to the formation of warts. Warts are rough, raised growths on the skin, usually caused by the human papillomavirus (HPV).

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Study Notes

Topical Therapy Principles

  • Topical medications come in various sizes (30g, 45g, 60g, 80g tubes or 454g jars).
  • Prescribe appropriate amounts; 30g for face for 1 month, 60g for two full body applications.
  • Avoid 30g tubes for rashes covering more than 50% of the body, requiring twice daily applications for two weeks.
  • Terms like "hypoallergenic", "unscented", and "sensitive skin" are marketing, not medical, terms. They don't guarantee no allergic reaction, fragrance-free products may contain fragrance, and sensitive skin products may be irritating.
  • Moisturizers and vehicles: Ointments, Creams, Lotions, Gels, and Solutions differ in moisture content with Ointments being very greasy and moisturizing, followed by creams and lotions. Gels are minimally moisturizing and drying, while solutions are very drying.
  • Effective moisturization: Apply a ceramide-based cream or petroleum jelly immediately after bathing before drying.
  • Soaps and shampoos are hydrophilic/hydrophobic molecules that bind oil, dissolve it in water for rinsing. This process removes natural oils, resulting in dryness and irritation.
  • Shampoos are formulated to prevent residue accumulation on hair but soaps are not.
  • Anti-dandruff shampoos usually contain zinc pyrithione, selenium sulfide, salicylic acid, sulfur, or tar.
  • For routine daily bathing, patients with dry skin should use soap/shampoo on face, groin, and axillary areas only.

Sunscreens

  • Sunscreens block UV radiation, categorized by SPF (Sun Protection Factor).
  • SPF calculation: Time in sun to cause sunburn with product / Time in sun to cause sunburn without product.
  • UV light types: UVC (blocked by ozone), UVB (measured by SPF), UVA.
  • Chemical blockers absorb UV light, converting it to infrared (heat).
  • Physical blockers (zinc oxide/titanium dioxide) reflect/scatter UV light, are stable and usually non-irritating.

Anti-Fungals

  • Two major classes: Allylamines (Terbinafine, Butenafine) good for dermatophyte infections, and Azoles (Ketoconazole, Econazole, Clotrimazole) which are effective for candida infections. Nystatin is effective for candida but not dermatophytes.

Acne Therapy

  • Match vehicle (gel/solution/cream) to skin type; retinoids are used at bedtime, and topical antibiotics in the morning.
  • Topical antibiotics include clindamycin, erythromycin, benzoyl peroxide-clindamycin (combination products), and metronidazole.
  • Topical steroids (Class 1-7) used for initial treatment. Ointments are stronger than creams, lotions, and solutions.

Other Treatments

  • Various treatments for different conditions (poison ivy, Xerosis, psoriasis, intertrigo, thrush, scabies, warts, molluscum, drug rash, etc.) are listed, including specific medications, frequencies, duration, and precautions.

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