Top Drug Torsemide Flashcards
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Questions and Answers

What is the brand name of Torsemide?

Demadex

What is the drug class of Torsemide?

Loop diuretic

What is the dosing for Torsemide in edema related to heart failure?

10-20 mg po daily, may titrate to maintenance dose (max 200 mg/d)

What is the MOA (Mechanism of Action) of Torsemide?

<p>Loop diuretic that decreases sodium reabsorption by competing for the chloride site on the Na+-K+-2Cl- cotransporter.</p> Signup and view all the answers

What is the dose adjustment renal for Torsemide?

<p>NONE</p> Signup and view all the answers

Are there pharmacogenetics for Torsemide?

<p>NONE</p> Signup and view all the answers

What are the contraindications to Torsemide?

<p>Hypersensitivity to torsemide or sulfonylureas, anuria, hepatic coma</p> Signup and view all the answers

What are the boxed warnings for Torsemide?

<p>NONE</p> Signup and view all the answers

What are the drug interactions with Torsemide?

<p>ACE-inhibitors, aminoglycosides, antidiabetic drugs, antiarrhythmic agents, bile acid resins, diuretics, lithium, NSAIDs</p> Signup and view all the answers

What are COMMON adverse reactions to Torsemide?

<p>NONE</p> Signup and view all the answers

What are RARE BUT SERIOUS adverse reactions to Torsemide?

<p>Angioedema, thrombocytopenia, electrolyte abnormalities, anuria</p> Signup and view all the answers

What are the efficacy monitoring parameters for Torsemide?

<p>Decreased BP, increased urine output, reduction in edema, daily weights</p> Signup and view all the answers

What are the toxicity monitoring parameters for Torsemide?

<p>Monitor serum and urine electrolytes, uric acid, and blood glucose</p> Signup and view all the answers

Study Notes

Torsemide Overview

  • Brand name: Demadex
  • Drug class: Loop diuretic

Dosing Information

  • For edema related to heart failure, renal failure, hepatic cirrhosis: initial dose of 10-20 mg PO daily (titrate to max 200 mg/d)
  • For hypertension: starting dose of 5 mg PO daily, titrate based on patient response

Mechanism of Action

  • Acts as a loop diuretic, inhibiting sodium reabsorption in the thick ascending limb of Henle's loop
  • Competes for the chloride site on the Na+-K+-2Cl- cotransporter

Renal Dose Adjustment

  • No adjustments required for renal impairment

Pharmacogenetics

  • No known pharmacogenetic implications

Contraindications

  • Hypersensitivity to torsemide or sulfonylureas
  • Anuria
  • Hepatic coma

Boxed Warnings

  • None specified

Drug Interactions

  • ACE-inhibitors: Increased risk of postural hypotension; start with a low dose and monitor blood pressure
  • Aminoglycosides: May increase serum concentrations, leading to ototoxicity and/or nephrotoxicity; avoid use
  • Antidiabetic drugs: May reduce hypoglycemic effects; monitor closely
  • Antiarrhythmic agents: Increased risk of ventricular arrhythmias due to hypokalemia; monitor potassium and magnesium levels
  • Bile acid resins: Reduced efficacy of torsemide; advise administration of cholestyramine 4 hours after torsemide
  • Diuretics: Can lead to increased diuretic response; monitor usage
  • Lithium: Increased risk of lithium toxicity; consider reducing lithium dose
  • NSAIDs: Reduced antihypertensive effect, potential nephrotoxicity; avoid concurrent use

Adverse Reactions

  • Common adverse reactions: None reported
  • Rare but serious reactions: Angioedema, thrombocytopenia, electrolyte abnormalities, anuria

Efficacy Monitoring Parameters

  • Target outcomes include decreased blood pressure, increased urine output, reduction in edema, and daily weight monitoring
  • For renal failure treatment, monitor increase in urine volume, creatinine clearance (CrCl), blood urea nitrogen (BUN), and electrolyte levels

Toxicity Monitoring Parameters

  • Monitor for severe volume depletion and check serum and urine electrolytes, uric acid, and blood glucose at baseline and every 3-6 months post-therapy

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Test your knowledge on Torsemide with these flashcards. This quiz includes information about the brand name, drug class, and dosing guidelines for Torsemide. Perfect for students and professionals in the healthcare field!

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