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Questions and Answers
What is the generic and trade name for tolterodine tartrate?
What is the generic and trade name for tolterodine tartrate?
What therapeutic class does tolterodine tartrate belong to?
What therapeutic class does tolterodine tartrate belong to?
Muscarinic receptor antagonist
What is the dosage range for tolterodine tartrate?
What is the dosage range for tolterodine tartrate?
PO 2mg bid; may decrease to 1 mg bid; extended release 4mg/day, may decrease to 2mg/day, max: 4mg/day
What is the route of administration for tolterodine tartrate?
What is the route of administration for tolterodine tartrate?
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What is the mechanism of action (MOA) of tolterodine tartrate?
What is the mechanism of action (MOA) of tolterodine tartrate?
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What are the indications for the use of tolterodine tartrate?
What are the indications for the use of tolterodine tartrate?
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Which of the following are major side effects of tolterodine tartrate? (Select all that apply)
Which of the following are major side effects of tolterodine tartrate? (Select all that apply)
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What are the contraindications for tolterodine tartrate? (Select all that apply)
What are the contraindications for tolterodine tartrate? (Select all that apply)
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What should be checked before administering tolterodine tartrate?
What should be checked before administering tolterodine tartrate?
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What should be monitored after administering tolterodine tartrate?
What should be monitored after administering tolterodine tartrate?
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Patients should be advised to avoid hazardous activities due to possible ___ from tolterodine tartrate.
Patients should be advised to avoid hazardous activities due to possible ___ from tolterodine tartrate.
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What important education should be provided to patients taking tolterodine tartrate?
What important education should be provided to patients taking tolterodine tartrate?
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Study Notes
Tolterodine Tartrate (Detrol) Overview
- Generic name: tolterodine tartrate; Trade names: Detrol, Detrol LA
- Therapeutic class: Muscarinic receptor antagonist
Dosage and Administration
- Dosage range: Oral 2 mg twice daily (bid); can reduce to 1 mg bid; extended-release: 4 mg daily, may reduce to 2 mg daily, max of 4 mg/day
- Route of administration: Oral, swallow whole with liquids
Pharmacokinetics
- Rapid absorption with high protein binding
- Metabolized in the liver and excreted through urineand feces
- Half-life: unknown
Mechanism of Action
- Relaxes smooth muscles in the urinary tract by inhibiting acetylcholine at post-ganglionic sites
Indications for Use
- Primarily indicated for overactive bladder
- Effective in treating urinary incontinence
Major Side Effects
- CNS effects: anxiety, paresthesia, fatigue, dizziness, headache, increased dementia risk, memory impairment
- Cardiovascular effects: chest pain, hypertension (HTN), prolonged QT interval, angioedema
- EENT effects: abnormal vision, xerophthalmia (dry eyes)
- Gastrointestinal/genitourinary effects: nausea, vomiting, anorexia, abdominal pain, constipation, dry mouth, urinary tract infection (UTI)
- Skin effects: bronchitis, cough, pharyngitis, and risk of Stevens-Johnson syndrome
Contraindications
- Known hypersensitivity to tolterodine
- Uncontrolled closed-angle glaucoma
- Urinary retention
- Gastric retention
Assessment Before Administration
- Check vital signs and assess neurological, cardiac, respiratory, and gastrointestinal status
- Evaluate patient's ability to swallow and monitor weight
- Review intake and output (I&O)
- Observe normal urinary patterns
- Take comprehensive history, including potential Stevens-Johnson syndrome
- Check for allergies
Monitoring After Administration
- Reassess vital signs, respiratory, and neurological status
- Monitor weight and I&O
- Watch for allergic reactions, chest pain, EKG abnormalities (e.g., prolonged QT), angioedema, and rash
Patient Education
- Advise patients to avoid hazardous activities due to potential dizziness
- Encourage patients not to drink liquids before bedtime to minimize nocturia
- Educate on the importance of bladder maintenance
- Instruct patients to take medication with liquids and swallow whole
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Description
This quiz covers the essential aspects of Tolterodine Tartrate, including its dosage, administration, pharmacokinetics, mechanism of action, and indications for use. Additionally, it highlights major side effects associated with the medication. Perfect for students studying pharmacology or healthcare professionals seeking to refresh their knowledge.
