Tolcapone and Levodopa-Carbidopa
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Questions and Answers

Which of the following is a potential benefit of using tolcapone in patients receiving levodopa-carbidopa treatment?

  • It decreases the risk of dyskinesia
  • It improves motor symptoms in Parkinson's disease
  • It inhibits the activity of COMT
  • It enhances the effects of levodopa (correct)

    • What is the main mechanism of action of tolcapone in patients treated with levodopa-carbidopa?

  • It enhances dopamine synthesis
  • It activates COMT
  • It blocks dopamine receptors
  • It inhibits COMT (correct)

    • Which of the following statements about tolcapone is true?

  • It is primarily used as a first-line treatment for Parkinson's disease
  • It can cause liver toxicity (correct)
  • It is a dopamine agonist
  • It has no impact on levodopa metabolism

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