Togaviruses: Symptoms and Characteristics

Several ______ cause disease in animals and humans> symptoms range from rashes, high fever to joint pain and encephalitis

______ glycoprotein binds to cellular receptors> receptor mediated endocytosis (e.g. laminin receptor) via clathrin coated vesicles

Linear ‘+’ sense ssRNA gneome ~9.7-11.8kb and has both 5’ methylated cap and a 3’ poly(A) tail (~70nt)

Spherical ______d particle with a fringe of projections (spikes)~ 70nm in diameter

Once in endosome, pH drop leads to conformational changes in E1/E2 heterodimer> leads to ______ after exposure of ______ domain - Fusion of endosome membrane with viral envelope> release of nucleocapsid

Capsid proteins interact with the cytoplasmic tails of envelope proteins studding the plasma membrane - Virus exits cell by

PE2: Precurosr to E2, palmitoylated and glycosylated Capsid: forms

Structural proteins are

NsP4: RNA

Virus exits cell by