Tirzepatide: A GLP-1 Agonist

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Questions and Answers

Why is tirzepatide contraindicated in patients with a history of pancreatitis?

The weight loss associated with tirzepatide leads to rapid fat mobilization, elevating serum triglyceride levels and precipitating pancreatitis in susceptible individuals.
Tirzepatide directly damages the pancreatic acinar cells, exacerbating existing damage.
Tirzepatide induces an autoimmune response targeting the pancreas due to its molecular structure resembling pancreatic antigens.
The drug's mechanism of action includes slowing gastric emptying, which increases pancreatic enzyme secretion and, consequently, the risk of inflammation in individuals susceptible to pancreatic issues. (correct)

How does tirzepatide's mechanism of action primarily contribute to its antidiabetic effect?

Via glucose-dependent insulin secretion, which reduces the risk of hypoglycemia compared to insulin secretagogues that are glucose-independent. (correct)
Through the direct stimulation of insulin release from pancreatic beta cells, irrespective of glucose levels, leading to a reduction in blood sugar.
By selectively blocking the reabsorption of glucose in the proximal renal tubules, resulting in increased glucose excretion.
By inhibiting hepatic glucose production through the suppression of key gluconeogenic enzymes.

Which statement best describes the advantage of using tirzepatide in combination with metformin for T2DM?

The combination allows for increased absorption of metformin in the gastrointestinal tract.
The combination mitigates the risk of lactic acidosis associated with metformin monotherapy.
Combining tirzepatide with metformin exclusively targets postprandial hyperglycemia.
Combining the medications addresses complementary mechanisms, decreasing insulin resistance and increasing insulin secretion. (correct)

What is the significance of tirzepatide being administered via subcutaneous injection?

This prevents degradation of the peptide structure of tirzepatide within the acidic environment of the stomach. (D) Signup and view all the answers

What is a key consideration when initiating tirzepatide therapy in a patient already on other antidiabetic medications?

The doses of other antidiabetic medications, particularly insulin or sulfonylureas, may need adjustment to mitigate the risk of hypoglycemia. (D) Signup and view all the answers

How does tirzepatide-induced weight loss potentially contribute to improved glycemic control in patients with T2DM?

Weight loss reduces insulin resistance in peripheral tissues, improving glucose uptake and utilization. (B) Signup and view all the answers

A patient taking tirzepatide reports persistent nausea. What is the most appropriate initial intervention?

Advise the patient to eat smaller, more frequent meals, avoid high-fat foods, and ensure adequate hydration, while continuing to monitor symptoms. (D) Signup and view all the answers

How does tirzepatide affect gastric emptying and what implication does this have for patients taking oral medications?

Tirzepatide slows gastric emptying, potentially altering the absorption rate of concurrently administered oral medications. (D) Signup and view all the answers

Which patient population would require the most cautious monitoring when prescribed tirzepatide, given its mechanism of action?

Patients with a history of gastroparesis or other significant gastrointestinal motility disorders. (B) Signup and view all the answers

What is the rationale behind administering tirzepatide once weekly rather than daily or multiple times per day?

The medication has a long half-life, providing sustained glucose control with less frequent administration. (B) Signup and view all the answers

Flashcards

Tirzepatide

A once-weekly injectable medication that can be used alone or with other diabetic medications.

Tirzepatide MOA

Enhances glucose-dependent insulin secretion, slows gastric emptying, and increases satiety.

Tirzepatide indication

Primarily indicated for the treatment of Type 2 Diabetes Mellitus.

Tirzepatide contraindication

A history of pancreatitis is a contraindication.

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Tirzepatide Side effect

Pancreatitis and weight loss are potential side effects..