Thyroid Neoplasms Quiz
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Questions and Answers

What is the most important environmental risk factor for papillary carcinoma of the thyroid?

  • RET mutations
  • Iodine excess
  • Iodine deficiency (correct)
  • Genetic mutations
  • Which type of thyroid carcinoma is characterized by mutations in TP53 and has poor prognosis factors such as age >40, extrathyroid extension, and distant metastases?

  • Medullary thyroid carcinoma
  • Anaplastic carcinoma (correct)
  • Papillary carcinoma
  • Follicular carcinoma
  • Which pathway do the follicular cell–derived malignancies cluster along, downstream of growth factor receptors and RAS?

  • (STAT) pathway
  • (MAP) kinase pathway (correct)
  • PI-3K/AKT pathway
  • (JAK) pathway
  • What is the most common form of thyroid cancer that presents with painless neck mass and has high 10-year survival rates?

    <p>Papillary carcinoma</p> Signup and view all the answers

    What is the most common thyroid carcinoma?

    <p>Papillary carcinoma</p> Signup and view all the answers

    Which criteria increase the possibility of a thyroid nodule being malignant?

    <p>A history of radiation</p> Signup and view all the answers

    What is the main pathogenesis of toxic adenomas?

    <p>TSH receptor (TSHR) and (GNAS)</p> Signup and view all the answers

    What are the majority of adenomas derived from?

    <p>Follicular epithelium</p> Signup and view all the answers

    How do most toxic adenomas appear relative to the adjacent normal thyroid gland?

    <p>Cold nodules</p> Signup and view all the answers

    Which thyroid carcinoma is associated with the presence of isolated cervical node metastases that do not significantly influence prognosis?

    <p>Papillary carcinoma</p> Signup and view all the answers

    What environmental factor is most strongly associated with papillary carcinoma of the thyroid?

    <p>Ionizing radiation</p> Signup and view all the answers

    Which form of thyroid cancer presents with a painless neck mass and has high 10-year survival rates?

    <p>Papillary carcinoma</p> Signup and view all the answers

    Which gene mutations are specifically associated with familial medullary thyroid carcinomas in multiple endocrine neoplasia type 2 (MEN-2)?

    <p>RET</p> Signup and view all the answers

    Which pathway do the follicular cell–derived malignancies cluster along, downstream of growth factor receptors and RAS?

    <p>(MAP) kinase pathway</p> Signup and view all the answers

    Which characteristic is associated with the majority of adenomas?

    <p>Nonfunctional</p> Signup and view all the answers

    What is the most common form of thyroid carcinoma?

    <p>Papillary carcinoma</p> Signup and view all the answers

    Which criteria increase the possibility of a thyroid nodule being malignant?

    <p>Nodules in very young patients</p> Signup and view all the answers

    What is the main pathogenesis of toxic adenomas?

    <p>TSH receptor (TSHR) and GNAS mutations</p> Signup and view all the answers

    What is the characteristic morphology of adenomas?

    <p>Well-circumscribed round to oval nodule with thin capsule</p> Signup and view all the answers

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