40 Questions
What is the primary role of thyroid hormones T3 and T4?
Roles: • Metabolic rate and heat production • Oxygen consumption • Fat, carbohydrate & lipid metabolism • Growth and development • Brain function • Stimulated by TSH from the anterior pituitary gland • Thyroid must have iodine to produce these hormones
Which hormone inhibits the resorption of calcium and phosphate in the body?
Calcitonin...........................................nhibits resorption of calcium & phosphate • Lowers serum calcium levels by retaining calcium/phosphate in the bones • Stimulated with hypercalcemia
What is a common cause of goiter?
Enlarged thyroid gland Entire gland or multiple nodules Can be associated with hyperthyroidism, hypothyroidism, or euthyroid state Causes: Lack of iodine in the diet Overproduction or underproduction of thyroid hormones Nodules in gland Medications containing thyroid-inhibiting substances
What are signs and symptoms of goiter
Enlarged thyroid Dysphagia Difficulty breathing- can compromise airway! Goiters can develop into cancer Nursing Concerns: ABCs Stridor is an emergency! Assess swallowing
What is treatment for a goiter?
reatment: Goals of treatment are to protect the airway and stop enlargement of the goiter Medications: dependent on etiology of goiter Thyroidectomy
How should levothyroxine be administered for the treatment of hypothyroidism?(Levothyroxine can produce nearly normal levels of both T3 & T4) Synthoid
n the early morning on an empty stomach (at least 30-60 minutes before food is consumed); food reduces the absorption of this medication Extra Info • Drug of choice for those who require thyroid hormone replacement • Treat s/s caused by hypothyroidism • Started at a low dose and gradually increased to prevent causing hyperthyroidism • Monitor for S/S of hyperthyroidism when beginning therapy or increasing dose • When administered in the appropriate dosage, levothyroxine rarely causes adverse effects • Educate patient to monitor for s/s of hyperthyroidism • S/S include: Tachycardia, angina/chest pain, palpitations, tremors, nervousness, hyperthermia, heat intolerance, and sweating • If these s/s occur, notify the physician right awa
What is hypothyroidism
Deficiency of thyroid hormone causing a general slowing of metabolic rate Classified as primary or secondary Iodine deficiency is most common cause worldwide Other causes: Hashimoto’s thyroiditis Thyroidectomy Congenital Discontinuance of thyroid hormone therapy
What is primary hypothyroidism.........Hint: In primary thyroid disease, T3/T4 & TSH are going in opposite directions
ssue is with the thyroid gland itself • Unable to produce thyroid hormones T3 and T4 Low • No issue with Anterior Pituitary Gland • Anterior Pituitary Gland is continuously releasing Thyroid Stimulating Hormone, attempting to stimulate the thyroid to release T3 & T4 High TSH
What is secondary hypothyroidism................................In secondary thyroid disease, T3/T4 & TSH are going in the same direction
Issue is with the Anterior Pituitary Gland • Unable to produce Thyroid Stimulating Hormone(TSH) TSH Low • No issue with Thyroid Gland • TSH is not being released, so the thyroid gland isn’t being stimulated to release its hormones T3 & T4 Low
What are signs and symtoms for hypothyroidism
Bradycardia Weight gain Fatigue & Lethargy Intolerant to cold Personality and mental changes Shortness of breath on exertion Atherosclerosis Constipation Dry skin and hair Heart failure Decreased cardiac output Can progress to myxedema
What is a hypothyroidism treatment medication?
Hormone replacement therapy with Levothyroxine (Synthroid) Education Lifelong medication Do not abruptly stop and avoid discontinuation S/S of hyperthyroidism after HRT Diabetic patients should check BG regularly
What is hashimotos disease
Autoimmune disease Antibodies attack healthy thyroid tissue Leads to inflammation Thyroid cells are destroyed hypothyroidism Women affected more than men Can cause goiter Signs and symptoms similar to hypothyroidism Diagnostic tests: Autoimmune antibody testing TSH, T3, T4 levels Thyroid scan Therapeutic measures: Thyroid hormone therapy
In Myxedema Coma, which of the following symptoms are typically observed?
Hypoventilation (can lead to respiratory acidosis) Hypothermia (less than 95°F) Hypotension Bradycardia Hypoglycemia Change in LOC Lethargy
What is the main cause of Myxedema Coma in patients with long-standing undiagnosed hypothyroidism?..............................acial puffiness, facial & periorbital edema, edema of hands and feet
Metabolic rate drops so low that it becomes life threatening Usually occurs in long-standing undiagnosed hypothyroidism Precipitated by infection, drugs (opioids, barbiturates), exposure to cold, trauma Mental sluggishness, drowsiness and lethargy have progressed to coma state T3/T4 low, TSH high or low
Which nursing intervention is crucial for patients with Myxedema Coma?
ntubation and mechanical ventilation Maintain patent airway! Respiratory support and frequent assessment Cardiac Monitoring IV fluids All medications administered intravenously IV Levothyroxine Warm patient with blankets or BAIR hugger When patients have recovered and are being discharged: Provide short, written reminders for care information
What is hyperthyroidism
ncrease in synthesis and release of thyroid hormones Excess circulating T3 and T4 Most commonly caused by Grave’s Disease antibodies cause thyroid to overproduce hormones
What is primary hyperthyroidism......................Hint: In primary thyroid disease, T3/T4 & TSH are going in opposite directions
ssue is with the thyroid gland itself • Over production of the thyroid hormones • T3 and T4 High • Anterior Pituitary Gland is not releasing Thyroid Stimulating Hormone, attempting to stop the thyroid from releasing T3 & T4 • TSH Low
what is secondary hyperthyroidism.................In secondary thyroid disease, T3/T4 & TSH are going in the same direction
Issue with the Anterior Pituitary Gland • Over production of Thyroid Stimulating Hormone (TSH) • TSH High • No issue with Thyroid Gland • TSH is being over produced, which is over stimulating the thyroid gland & the thyroid is continuously producing and releasing T3 & T4 • T3 & T4 High
Hyperthroidism pathos and etiology
Pathophysiology Increased Metabolic Rate Increased Beta-Adrengergic Receptor Sites in body Enhances activity of epinephrine & norepinephrine Etiology Graves Disease Autoimmune disease Characterized by thyroid enlargement and excessive thyroid hormone secretion Thyroid nodules Multinodular goiter Thyroiditis Thyroid tumor Pituitary tumor
What are hyperthyroidism signs and symptoms
Signs and Symptoms Hypermetabolic State Everything is sped up! Heat Intolerance Internal temperatures are elevated, warm skin Tachycardia, Palpitations, Hypertension, Chest Pain Due to increased epinephrine/norepinephrine activity Risk for angina and dysrhythmias Increased Appetite, Weight Loss, Frequent Stools Fatigued & Irritable Nervousness, Tremors Goiter Exophthalmos (occurs only with Graves’ disease) Tissues behind eyes swell
What are nursing care and clinical manifestations for hyperthyroidism
Goiter Assess airway and ability to swallow Cardiac Complications (HTN, Tachycardia, Palpitations) Administer beta blockers as ordered Irritability & Restlessness Provide quiet environment Exophthalmos Relieve dry eyes & discomfort (eye drops) Weight Loss Increase carbs, proteins, fats, overall calorie intake
What are hyperthyroidism interventions
Many treatments to attempt to slow the thyroid down Antithyroid Medications Methimazole or PTU Radioactive iodine therapy (RAI) Thyroidectomy- removal of all or part of the thyroid Chosen when patient is unresponsive to other tx., has a goiter causing tracheal compression, thyroid cancer Will cause hypothyroidism, must be placed on Synthroid for life
What is radioactive Idone therpay for Hyperthyroidism
Destroys thyroid tissue – symptoms of hypothyroidism may occur as RAI therapy takes effect Nursing care (in hospital): Limit time spent with patient. Glove and gown. Avoid if pregnant. Take precautions with urine, emesis, body fluids. Double flush toile
What is antithyroid agent(methimazole, tapazole) given daily PO for hyperthyroidism
First line treatment for hyperthyroidism • Inhibits thyroid hormone synthesis......................Although methimazole inhibits thyroid hormone synthesis, it does not destroy existing stores of thyroid hormone • It can take 3 to 12 weeks to produce a euthyroid state • If doses administered are too high, it can put the patient into a hypothyroid state • Educate the patient on s/s of hypothyroidism, report to the provider if s/s present • If hypothyroidism occurs, dose should be decreased • Other medications may need to be administered to treat s/s while methimazole is being given to reach a euthyroid state
What are thioamides(proplithioracil, prpyl-thyracil) taken 2-3 times a day
second line treatment for hyperthyroidism • Inhibits thyroid hormone synthesis...............................lthough PTU inhibits thyroid hormone synthesis, it does not destroy existing stores of thyroid hormone • It can take 3 to 12 weeks to produce a euthyroid state • If doses administered are too high, it can put the patient into a hypothyroid state • Educate the patient on s/s of hypothyroidism, report to the provider if s/s present • If hypothyroidism occurs, dose should be decreased • Other medications may need to be administered to treat s/s while PTU is being given to reach a euthyroid state
What is a life-threatening emergency condition characterized by extreme tachycardia, hypertension, hyperthermia, and seizures?
Thyrotoxic crisis/thyroid storm----------------------Acute, rare condition in which hyperthyroid manifestations are HEIGHTENED Life-threatening emergency Can be caused by stressors in a patient with preexisting hyperthyroidism or after thyroid surgery
Which are signs and symptoms of Thyrotoxic Crisis/Thyroid Storm?
Symptoms: Tachycardia (>150-160 bpm) Extreme HTN Hyperthermia Seizures N/V/D Brief attention span, apprehension and restlessness Delirium Shock Heart failure Coma
How do you manage and treat thyroid storm
Beta Blockers Antipyretics/cooling blanket Fluid Replacement Elevate HOB Administer O2 Reduce circulating thyroid hormones Antithyroid drugs: PTU and Methimazole (block synthesis) Radioactive iodine (inhibits release of hormones into circulation) Results are not immediate – may take months to reach maximum effec
What is thyroidectomy pre-op care
Total or subtotal thyroidectomy Monitor breathing and swallowing Assess nutrition status Monitor vital signs Administer iodine or antithyroid drugs to achieve euthyroid state
What is post-op care for thyroidectomy
Neck swelling/airway complications Stridor – emergency! Tracheostomy equipment at bedside Monitor vitals! Worried for thyroid storm 18 hours post-op 101 greater risk for seizures BP increasing 180/100 stroke HR over 150 Restlessness increased confusion Stridor on excalation Hypothyroidism complications Monitor drain Semi-fowler position Suction equipment at bedside
What is the most common etiology of hyperparathyroidism?
Increased secretion of PTH Increased serum calcium Etiology: Hyperplasia Benign tumor of parathyroid glands Hereditary Secondary: Kidney disease
Which of the following diagnostic tests are typically used for hyperparathyroidism?
Diagnostic tests Serum calcium elevated 24-hour urine for calcium Phosphate decreased PTH elevated X-rays for bone density
What symptom are commonly associated with hyperparathyroidism?
Clinical Manifestations: Can be asymptomatic, or... Osteoporosis fractures Kidney Stones (hypercalciuria) Muscle weakness, lethargy Loss of appetite, N/V, constipation Peptic ulcers Coma Cardiac arrhythmias Cardiac arrest Patients at risk for injury!
What is the most effective treatment for hyperparathyroidism?
Most effective treatment? Remove it! Parathyroidectomy Nonsurgical therapy For asymptomatic patients Weight-bearing exercise, high fluid intake, moderate calcium intake Drugs to lower calcium levels -do not correct underlying problem
What is a potential complication post-parathyroidectomy that requires immediate nursing intervention?
Similar to that of thyroidectomy: Monitor for hemorrhage, fluid/electrolyte imbalance, airway Tetany can occur due to sudden decrease of calcium levels At risk for seizures and compromised airway issues Muscular spasms, laryngospasms – Administer IV Calcium! Keep IV Calcium Gluconate readily available for patients post-op Monitor I&Os to assess fluid/electrolyte balance Calcium and Vitamin D supplements Encourage mobility Tetany
What is a common emergency intervention for tetany due to hypoparathyroidism?
IV Calcium gluconate
What long-term dietary management is recommended for patients with hypoparathyroidism?
High calcium diet
Which sign is considered normal post-op and not indicative of hypoparathyroidism?
Chvostek's sign
In hypoparathyroidism, what should be avoided in terms of drug therapy?
PTH administration
What is a key aspect of long-term care for hypoparathyroidism patients?
High calcium diet
Explore the roles of thyroid hormones T3 and T4 in metabolic rate, heat production, oxygen consumption, growth, development, and brain function. Learn about the stimulation of these hormones by TSH and the importance of iodine for their production. Discover the inhibitory functions of calcitonin on calcium resorption and its role in regulating serum calcium levels.
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