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Thyroid Hormones and Biosynthesis

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Questions and Answers

What is the function of the enzyme 'iodothyronine deiodinase' in the synthesis of thyroid hormones?

It catalyzes the reductive process of deiodination to convert T4 to T3 (correct)

It catalyzes the formation of iodothyronines from iodotyrosines

It catalyzes the proteolysis of thyroglobulin and release of T4 and T3

It catalyzes the oxidation of iodide and formation of iodotyrosyine residues

What are the two major thyroid hormones formed by the coupling of two DIT or one DIT with one MIT residue?

T3 and rT3

rT3 and T4

MIT and DIT

T4 and T3 (correct)

What is the function of thyroglobulin proteolysis?

It converts T4 to T3

It releases T4 and T3 into the blood (correct)

It catalyzes the oxidation of iodide and formation of iodotyrosyine residues

It forms iodothyronines from iodotyrosines

What is the name of the prodrug derivative of methimazole?

Carbimazole Signup and view all the answers

What are the two rings in the nomenclature of thyroid hormones?

Inner ring and outer ring Signup and view all the answers

What is the function of antithyroid drugs?

To treat hyperthyroidism Signup and view all the answers

What is the origin of prostaglandins?

Mammalian tissue Signup and view all the answers

What is the first step in the biosynthesis of thyroid hormones?

Accumulative uptake of iodide by the follicular cell Signup and view all the answers

What is the full name of L-Thyroxine (T4)?

L-(-)-3,5,3’,5’-tetraiodo-L-thyronine Signup and view all the answers

What is the function of iodide in the treatment of hyperthyroidism?

It is used as an antithyroid drug Signup and view all the answers