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Thyroid Hormone Synthesis

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What is unique about the synthesis of thyroid hormones T3 and T4?

They involve the use of a rare element.

What is the purpose of thyroglobulin?

To release thyroid hormones on need from the colloid.

Where does the conversion of T4 to T3 occur?

In peripheral tissues

What is the significance of the conversion of T4 to T3?

It makes T3 a more active hormone

What is the relationship between thyroglobulin and thyroid hormones?

Thyroglobulin is a precursor molecule for thyroid hormones

Study Notes

Thyroid Hormones T3 and T4

  • Unique feature of T3 and T4: require iodide, a rare element, for their synthesis.
  • T3 and T4 are synthesized as part of a large precursor molecule called thyroglobulin.
  • Thyroglobulin is stored in the colloid to be released as needed.
  • Peripheral conversion of T4 to T3 occurs, resulting in a much more active hormone (T3).

Learn about the unique characteristics of thyroid hormones T3 and T4, including the role of iodide and thyroglobulin in their synthesis. Understand the peripheral conversion of T4 to T3 and its significance.

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