30 Questions
What is the peak effect time for T3 compared to T4?
6-8 hours for T3 and 24-48 hours for T4
Which hormone is considered to be more active in vitro?
T3
Which hormone binds more tightly to plasma proteins?
T4
What percentage of T3 is produced by the thyroid gland?
20%
Which thyroid hormone is considered to be four times more potent than the other?
T3
What is the primary use of Levothyroxine sodium (T4)?
Thyroid replacement and suppression therapy
What is the advantage of levothyroxine in terms of dosing frequency?
Once-daily administration
Why is liothyronine not recommended for routine replacement therapy?
Shorter half-life of 24 hours
What is the primary reason for avoiding liothyronine in patients with cardiac disease?
Greater hormone activity and risk of cardiotoxicity
What is the clinical use of liotrix in treating hypothyroidism?
Cretinism & myxedema
Which type of reaction can result from an overuse of thyroxine?
Thyrotoxicosis
How do anti-thyroid drugs treat hyperthyroidism?
Inhibit thyroid hormone synthesis by binding to TPO
What is the most likely cause of SJ's dry skin, coarse and brittle hair, and lack of energy?
Autoimmune thyroiditis
What screening test is recommended to diagnose hypothyroidism in patients with SJ's symptoms?
TSH with reflex free T4
What is the definition of subclinical hypothyroidism based on the information provided?
TSH 5-10 mIU/ml
Which of the following conditions is NOT listed as an indication for screening for thyroid disease?
Chronic fatigue
What laboratory finding, in addition to the elevated TSH, confirms the diagnosis of autoimmune thyroiditis (Hashimoto's disease) in SJ's case?
Elevated TPO antibodies
What is the initial treatment for SJ's subclinical hypothyroidism?
Levothyroxine 25mcg daily
What is the primary function of the thyroid gland?
To store and produce thyroid hormones
Which of the following is NOT a dietary source of iodide?
Fruits
What is the recommended daily iodine requirement for pregnant and lactating women?
200 μg
Which of the following statements about iodine and iodide is correct?
Iodine denotes all forms of the element, and iodide denotes only the ionic form (I-)
What is the approximate total body content of iodine in an adult?
30 - 50 mg
Which of the following steps is NOT involved in the synthesis of thyroid hormones?
Deiodination
Which medication is considered the drug of choice for managing thyrotoxicosis?
Methimazole
What symptom should a patient report immediately if experiencing while on methimazole therapy?
Jaundice
How should doses of methimazole be tapered during treatment?
Every month
What symptom should a patient report if they suspect agranulocytosis while on methimazole?
Fever and malaise
Which thyroid disorder is associated with the presence of exophthalmos?
Thyrotoxicosis
What test is used to diagnose Thyroid Stimulating Hormone Receptor Antibody?
TSH with reflex free T4
Test your knowledge on the biosynthesis of thyroid hormone. Explore the unique characteristics of the thyroid gland, the role of iodide, dietary sources, and daily requirements for adults.
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