Thyroid Disorders Pathology
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Questions and Answers

What is the classic variant of papillary thyroid carcinoma characterized by?

BRAF V600E

What are the culprit antibodies in Hashimoto thyroiditis?

Antithyroid peroxidase and antithyroglobulin

What gene mutation is associated with adrenal cortical carcinoma?

Insulin-like growth factor 2 (IGF2) overexpression

What is the main cause of iodine deficiency-related goiter?

<p>Increase in TSH secretion</p> Signup and view all the answers

What is the result of the secretion of fluids from the lining epithelial cells in a thyroglossal duct cyst?

<p>Cystic dilation</p> Signup and view all the answers

What risk factor is best established for papillary thyroid carcinoma?

<p>Ionizing radiation</p> Signup and view all the answers

What are the histological hallmarks of papillary thyroid carcinoma?

<p>Fingerlike projections, nuclear features like inclusion bodies, and abundant mitosis</p> Signup and view all the answers

What is the cardinal feature of pheochromocytoma?

<p>Often sporadic but can be associated with genetic syndromes</p> Signup and view all the answers

What is the most common cause of hypothyroidism?

<p>Hashimoto thyroiditis</p> Signup and view all the answers

What are the nuclear features seen in adrenal cortical carcinoma?

<p>Large cells with granular clear to eosinophilic cytoplasm, pleomorphism, inclusion bodies</p> Signup and view all the answers

What is the only normal remnant of the thyroglossal duct?

<p>The pyramidal lobe of the thyroid gland</p> Signup and view all the answers

What diagnostic method is important for thyroglossal duct cyst?

<p>Scintigraphy</p> Signup and view all the answers

What is the first described name associated with Hashimoto thyroiditis?

<p>Hakaru Hashimoto</p> Signup and view all the answers

What is the most common developmental anomaly of the thyroid gland?

<p>Thyroglossal duct cyst</p> Signup and view all the answers

What is the gender predilection for Adrenal cortical carcinoma?

<p>More common in females</p> Signup and view all the answers

What is the mean age range for the diagnosis of Adrenal cortical carcinoma?

<p>30-40 years old</p> Signup and view all the answers

Which gene mutation is associated with Diffuse Gastric Adenocarcinoma?

<p>CDH1 gene</p> Signup and view all the answers

In Hashimoto thyroiditis, what causes oxidative damage to follicular cells?

<p>Normal TSH</p> Signup and view all the answers

What is the most common type of thyroid cancer?

<p>Papillary thyroid carcinoma</p> Signup and view all the answers

What is the mechanism of thyroid failure in Hashimoto thyroiditis?

<p>Autoimmune destruction</p> Signup and view all the answers

What is the common gender ratio for Multinodular goiter?

<p>More common in females</p> Signup and view all the answers

Which condition may lead to compression of adjacent structures in the neck?

<p>Nodular neck mass</p> Signup and view all the answers

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