Thyroid Disorders Overview
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Questions and Answers

What is the primary mechanism of action of alpha-blockers in the treatment of benign prostatic hyperplasia?

  • They decrease dihydrotestosterone levels.
  • They increase bladder capacity.
  • They block the alpha-1a receptor. (correct)
  • They shrink the prostate size.
  • What percentage of men typically experience symptom improvement within the first week of starting alpha-blocker therapy?

  • 90%
  • 50% (correct)
  • 25%
  • 75%
  • Which of the following is an adverse effect associated with the use of alpha-blockers?

  • Weight gain
  • Prolonged erection (correct)
  • Elevated blood pressure
  • Increased dihydrotestosterone
  • How long may patients retain symptom relief after starting alpha-blocker therapy?

    <p>4 years (D)</p> Signup and view all the answers

    What is a potential drawback of 5-alpha-reductase inhibitors in treating benign prostatic hyperplasia?

    <p>They require 3 to 6 months for effect. (D)</p> Signup and view all the answers

    What is the primary function of thyroid hormones in the body?

    <p>Balancing body temperature, metabolism, and heart rate (D)</p> Signup and view all the answers

    What condition is predominantly linked to hyperthyroidism caused by abnormal antibodies?

    <p>Graves' disease (D)</p> Signup and view all the answers

    Which of the following is NOT a symptom of hyperthyroidism?

    <p>Weight gain (B)</p> Signup and view all the answers

    What is the primary treatment aim for patients with hyperthyroidism?

    <p>Normalize thyroid hormone production and minimize symptoms (A)</p> Signup and view all the answers

    In a Toxic Nodular Goiter, what initiates thyroid dysfunction?

    <p>TSH-secreting tumors (B)</p> Signup and view all the answers

    What may trigger the immune system to produce abnormal thyroid-stimulating antibodies in Graves' disease?

    <p>Environmental factors and genetics (B)</p> Signup and view all the answers

    What is a common recommendation for patients with Graves' disease regarding lifestyle choices?

    <p>Avoid smoking (C)</p> Signup and view all the answers

    What effect does hyperthyroidism generally have on metabolism?

    <p>Causes hypermetabolic state (D)</p> Signup and view all the answers

    What is the first-line treatment for hypothyroidism in pregnancy?

    <p>Levothyroxine (Synthroid) (B)</p> Signup and view all the answers

    Which of the following complications can arise from untreated hypothyroidism during pregnancy?

    <p>Preeclampsia (B)</p> Signup and view all the answers

    What is the recommended blood testing for those who might have thyroid dysfunction postpartum?

    <p>Serum TSH testing (C)</p> Signup and view all the answers

    What should clinicians consider when diagnosing testosterone deficiency?

    <p>Symptoms of testosterone deficiency plus low levels (A)</p> Signup and view all the answers

    Which testosterone replacement therapy side effect is particularly concerning for certain patients?

    <p>Worsening sleep apnea (A)</p> Signup and view all the answers

    What is an important consideration before initiating testosterone therapy in men over 40?

    <p>Measurement of prostate-specific antigens (B)</p> Signup and view all the answers

    What are the risks of untreated hyperthyroidism during pregnancy?

    <p>Thyroid storm and CHF (B)</p> Signup and view all the answers

    Which of the following is considered a cause of testosterone deficiency?

    <p>Testicular injury (B)</p> Signup and view all the answers

    What is the primary goal of testosterone therapy?

    <p>Enhance quality of life for symptomatic deficiency (C)</p> Signup and view all the answers

    What factor can increase the dosage requirements for thyroid hormone replacement during pregnancy?

    <p>Increased metabolic demand (C)</p> Signup and view all the answers

    Why is propylthiouracil preferred over methimazole during pregnancy?

    <p>Reduced risk of drug transfer to fetus (C)</p> Signup and view all the answers

    What hormone does the fetus rely on from the parent during the first trimester?

    <p>Thyroid hormone (D)</p> Signup and view all the answers

    What percentage of women may develop a thyroid disorder postpartum?

    <p>5% (D)</p> Signup and view all the answers

    What common cardiovascular event risk is associated with testosterone therapy?

    <p>Myocardial infarction (B)</p> Signup and view all the answers

    What is a potential consequence of long-term testosterone therapy?

    <p>Increased risk of breast cancer (C)</p> Signup and view all the answers

    Which condition is NOT a contraindication for testosterone therapy?

    <p>Obesity (C)</p> Signup and view all the answers

    Which factor is commonly associated with erectile dysfunction?

    <p>Stress and anxiety (B)</p> Signup and view all the answers

    What is the primary mechanism of action of phosphodiesterase type 5 (PDE5) inhibitors?

    <p>Smooth muscle relaxation and increased blood flow (A)</p> Signup and view all the answers

    What is a common side effect of PDE5 inhibitors?

    <p>Priapism (B)</p> Signup and view all the answers

    What should be monitored while a patient is receiving testosterone therapy?

    <p>Liver enzyme levels (B)</p> Signup and view all the answers

    How should PDE5 inhibitors be taken prior to sexual intercourse?

    <p>1 hour before (C)</p> Signup and view all the answers

    What is a characteristic symptom of benign prostatic hyperplasia (BPH)?

    <p>Nocturia (A)</p> Signup and view all the answers

    Which statement about erectile dysfunction is true?

    <p>It may indicate underlying health problems (B)</p> Signup and view all the answers

    Which of the following medications can be used to treat BPH?

    <p>Alpha-1 blockers (C)</p> Signup and view all the answers

    What effect does testosterone have on spermatogenesis?

    <p>Decreases spermatogenesis (A)</p> Signup and view all the answers

    What lifestyle behavior can negatively impact erectile function?

    <p>Alcohol ingestion (C)</p> Signup and view all the answers

    Which condition can lead to erectile dysfunction?

    <p>High blood pressure (D)</p> Signup and view all the answers

    What aspect of PDE5 inhibitors should be considered when interacting with other drugs?

    <p>They may potentiate hypotensive effects (C)</p> Signup and view all the answers

    What is the most common cause of hypothyroidism?

    <p>Hashimoto's thyroiditis (C)</p> Signup and view all the answers

    Which medication is mentioned as a beta-adrenergic blocker for treating symptoms of tachycardia?

    <p>Propranolol (D)</p> Signup and view all the answers

    What is the initial recommended dosage range for levothyroxine in adults?

    <p>75-125 mcg (B)</p> Signup and view all the answers

    Which symptom is NOT typically associated with hypothyroidism?

    <p>Weight loss (A)</p> Signup and view all the answers

    Which dietary factor can contribute to thyroid dysfunction?

    <p>Low-iodine diet (A)</p> Signup and view all the answers

    What is the primary goal of thyroid replacement therapy?

    <p>To normalize thyroid-stimulating hormone levels (A)</p> Signup and view all the answers

    What is a common reason why levothyroxine may need dosage adjustments in elderly patients?

    <p>Lower absorption rates (C)</p> Signup and view all the answers

    Which drug's effectiveness is reduced when taken alongside calcium and iron supplements?

    <p>Levothyroxine (B)</p> Signup and view all the answers

    What potential effect does taking levothyroxine have on warfarin?

    <p>Decrease in vitamin K-dependent factors (D)</p> Signup and view all the answers

    Which of the following describes postpartum thyroiditis?

    <p>Autoimmune attack on the thyroid after pregnancy (C)</p> Signup and view all the answers

    Which symptom indicates potential over-replacement of thyroid hormone?

    <p>Heart palpitations (A)</p> Signup and view all the answers

    Which hormone is crucial for the normal development of a baby's brain during pregnancy?

    <p>Thyroid hormone (C)</p> Signup and view all the answers

    T3 supplementation may be added to treatment if a patient remains symptomatic despite adequate T4 therapy because:

    <p>T3 has a short lifespan in the body (A)</p> Signup and view all the answers

    What is a serious warning associated with thyroid hormones, such as levothyroxine?

    <p>Use for weight loss (D)</p> Signup and view all the answers

    Flashcards

    Thyroid Hormones

    Hormones (T3 and T4) produced by the thyroid gland that regulate body temperature, metabolism, and heart rate.

    Hyperthyroidism

    A condition where the thyroid gland produces too much thyroid hormone, leading to a hypermetabolic state.

    Grave's Disease

    A type of hyperthyroidism caused by abnormal antibodies mimicking thyroid-stimulating hormone (TSH).

    Toxic Nodular Goiter

    Hyperthyroidism caused by a hyper-functioning nodule within a goiter.

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    Thyroid-stimulating Antibodies

    Antibodies in Grave's disease that act like TSH, causing the thyroid gland to produce excessive hormones.

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    Hypermetabolic State

    A state where the body's metabolism is elevated and accelerated.

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    Antithyroid Treatment

    Treatments to normalize hormone production and decrease complications. e.g. surgery, radioactive ablation, or medication

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    Euthyroid State

    A normal thyroid hormone level (e.g the target of antithyroid treatment).

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    Hypothyroid in Pregnancy

    A condition where the mother's thyroid gland does not produce enough thyroid hormone during pregnancy.

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    Hyperthyroid in Pregnancy

    A condition where the mother's thyroid gland produces too much thyroid hormone during pregnancy.

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    Untreated Hypothyroid in Pregnancy

    Lack of treatment for low thyroid hormone during pregnancy.

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    Untreated Hyperthyroid in Pregnancy

    Lack of treatment for high thyroid hormone during pregnancy.

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    Fetal Dependence on Thyroid

    The fetus relies solely on the mother's thyroid hormone supply until the first trimester.

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    Levothyroxine (Synthroid)

    A synthetic thyroid hormone medication used to treat hypothyroidism during pregnancy.

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    Hypothyroid Dosage in Pregnancy

    The dosage of levothyroxine needs to be significantly increased during pregnancy.

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    PTU (Propylthiouracil)

    A medication used to treat hyperthyroidism during pregnancy.

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    Methimazole

    Another medication used to treat hyperthyroidism during pregnancy.

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    PTU vs. Methimazole

    PTU is preferred over methimazole because it binds to protein more readily, reducing placental transfer to the fetus.

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    Postpartum Thyroid Screening

    Checking TSH levels after childbirth to identify thyroid disorders.

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    Testosterone Deficiency: Primary

    Low testosterone caused by problems with the testicles.

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    Testosterone Deficiency: Secondary

    Low testosterone caused by problems with the hypothalamus or pituitary gland.

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    Testosterone Deficiency Symptoms

    Several symptoms can indicate testosterone deficiency, including low libido, fatigue, and decreased muscle mass.

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    Testosterone Therapy

    Treatment to replace low testosterone levels.

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    Hashimoto's Thyroiditis

    The most common cause of hypothyroidism, an autoimmune disorder where the body attacks the thyroid gland.

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    Postpartum Thyroiditis

    Inflammation of the thyroid gland that occurs after pregnancy, often with high thyroid hormone levels followed by a drop.

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    T4 (Thyroxine)

    The main thyroid hormone replaced by levothyroxine, converted into the active form T3 in the body.

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    T3 (Triiodothyronine)

    The active form of thyroid hormone that regulates metabolism.

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    Thyroid Replacement Therapy

    Treatment for hypothyroidism involving taking synthetic thyroid hormone to replace the missing hormone.

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    Over-replacement of Thyroid Hormone

    Taking too much thyroid hormone, which can lead to hyperthyroid symptoms like rapid heartbeat and weight loss.

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    Triiodothyronine (T3) Supplementation

    Taking extra T3 along with levothyroxine when some patients remain symptomatic despite adequate T4 replacement.

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    Warfarin and Levothyroxine Interaction

    Levothyroxine can increase the effects of warfarin, a blood thinner.

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    Levothyroxine Absorption Issues

    Certain medications and supplements can decrease the absorption and effectiveness of levothyroxine.

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    Importance of Thyroid Function in Pregnancy

    Thyroid hormones are crucial for the baby's brain and nervous system development during pregnancy.

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    Pregnancy and Thyroid Hormone Levels

    Pregnancy hormones can temporarily increase thyroid hormone levels in the mother.

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    Alpha-blockers for BPH

    Medications that relax muscles in the bladder, prostate, and neck to ease urine flow. They improve symptoms quickly but don't shrink the prostate or slow its growth.

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    5-Alpha-Reductase Inhibitors

    These drugs block a hormone (dihydrotestosterone) that makes the prostate grow, leading to a smaller prostate and improved urine flow. They take longer to work than alpha-blockers.

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    Alpha-blockers: Side Effects

    Common side effects of alpha-blockers include low blood pressure, tiredness, prolonged erections, and abnormal heart rhythms.

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    5-Alpha-Reductase Inhibitors: Side Effects

    Possible side effects include allergic reactions, breast or prostate cancer risk, decreased libido, abnormal ejaculation, erectile dysfunction, breast enlargement, and dizziness.

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    BPH Treatment Options

    Two main drug classes for BPH treatment are alpha-blockers and 5-alpha-reductase inhibitors. Each has distinct effects and side effects.

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    Testosterone Therapy Risks

    Long-term testosterone therapy for hypogonadism can increase the risk of breast cancer in men, alter lipid profiles, and potentially lead to gynecomastia, BPH, prostate cancer, and blood clots.

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    Erectile Dysfunction

    Persistent inability to achieve or maintain an erection sufficient for sexual intercourse.

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    Erectile Dysfunction Causes

    Cardiovascular disease, high blood pressure, obesity, low testosterone, aging, stress, anxiety, and depression can contribute to erectile dysfunction.

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    Erectile Dysfunction Mechanism

    Sexual stimulation releases nitric oxide, dilating blood vessels in the penis. This is facilitated by cGMP, an enzyme broken down by PDE5.

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    PDE5 Inhibitors

    Drugs like Viagra, Cialis, and Levitra that inhibit PDE5, allowing cGMP to persist and promote blood flow to the penis.

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    PDE5 Inhibitors for BPH

    PDE5 inhibitors can also be used to treat benign prostatic hyperplasia (BPH), by relaxing muscles in the prostate and bladder.

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    PDE5 Inhibitor Side Effects

    Common side effects include headache, indigestion, facial flushing, and abnormal vision.

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    PDE5 Inhibitor Metabolism

    PDE5 inhibitors are metabolized by CYP450 enzymes, leading to interactions with other drugs metabolized by the same pathway.

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    PDE5 Inhibitor Contraindications

    Should not be taken with nitrates due to risk of severe hypotension.

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    BPH

    Benign Prostatic Hyperplasia, an enlarged prostate gland, commonly occurring with age.

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    BPH Symptoms

    Frequent urination, urgency, difficulty starting urination, weak stream, dribbling, and inability to fully empty the bladder.

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    BPH Treatment

    Medications like alpha-blockers, minimally invasive therapies, and surgery can be used to manage BPH symptoms.

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    Alpha-Blocker Effectiveness

    Alpha-blockers like tamsulosin (Flomax) work faster in men with smaller prostates.

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    BPH Symptom Severity

    BPH symptoms can vary greatly and may worsen gradually over time.

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    Study Notes

    Thyroid Disorders

    • Thyroid hormones (T3 and T4) regulate body temperature, metabolism, and heart rate.
    • Most T3 is protein-bound.
    • Hyperthyroidism:
      • Two main types: Grave's Disease and Toxic Nodular Goiter.
      • Grave's Disease: Immune system produces antibodies mimicking TSH, causing overproduction of thyroid hormones. Unclear cause, likely genetic and environmental triggers. Most common cause of hyperthyroidism. Smoking worsens eye symptoms.
      • Toxic Nodular Goiter: Hyperfunctioning nodule develops in a goiter, leading to hyperthyroidism without eye problems.
      • Symptoms: Tremors, rapid heart rate (tachycardia), rapid breathing (tachypnea), heat intolerance, bulging eyes (exophthalmos), swelling of the shins (pretibial edema).
      • Hypermetabolic state.
    • Hypothyroidism:
      • Most common cause is Hashimoto's thyroiditis (inflammation of the thyroid gland). Autoimmune disorder where the body attacks the thyroid. Other causes include viral infections, neck radiation, certain medications, pituitary/hypothalamus disorders, and surgery. Low-iodine diets are also a contributing factor. Postpartum thyroiditis may occur after pregnancy.
      • Symptoms: Lethargy, fatigue, weight gain, skin changes, cold sensitivity, constipation, high blood fats (hyperlipidemia), slow heart rate (bradycardia).
      • Hypometabolic state.
    • Medications inducing thyroid dysfunction: Lithium, amiodarone, interferon.
    • Treatment goals: Replace missing hormone, normalize TSH levels, with synthetic therapy primarily. Levothyroxine (T4) is the primary synthetic therapy. T4 converts to T3.
    • Levothyroxine (T4)
      • Highly protein bound (97%).
      • Initial adult dose: 75-125 mcg (or ~1.6 mcg/kg/dl of ideal body weight).
      • Elderly dose: 75% or less than adult dose, start low and go slow.
      • Monitor for cardiac symptoms and adjust dose as needed.
      • 5-6 drug half-lives, testing interval 6-8 weeks after dose changes, then every 6-12 months for stable TSH.
    • Absorption reducers: Proton pump inhibitors, calcium & iron supplements, aluminum-containing antacids.
    • Warfarin interaction: Levothyroxine accelerates breakdown of Vitamin K-dependent clotting factors, so warfarin dosage may need adjustment.
    • Insulin and digoxin needs may increase.
    • Over-replacement symptoms: Similar to hyperthyroidism symptoms (fast heart rate, trouble sleeping, jittery feeling, sweating, anxiety, diarrhea, weight loss, bone loss).
    • T3 therapy: May be used in some cases of persistent symptoms despite T4 therapy, but needs specialist consultation. T3 has short lifespan, multiple daily doses, and fluctuation risk of hyperthyroid symptoms.
    • Black box warning: Do not use thyroid hormones for weight loss. Large doses in euthyroid patients can be toxic, especially with anorexic drugs.

    Thyroid in Pregnancy and Lactation

    • Thyroid hormones essential for fetal brain and nervous system development (fetus depends on mother's supply in first trimester).
    • Fetus's thyroid starts working independently around 12 weeks but fully functional around 18-20 weeks,
    • Pregnancy hormones (hCG and estrogen) increase measured thyroid hormone levels.
    • Diagnosing in pregnancy can be difficult.
    • Untreated hypothyroidism: Preeclampsia, anemia, miscarriage, low birth weight (LBW), heart failure (CHF).
    • Untreated hyperthyroidism: Miscarriage, premature birth, LBW, preeclampsia, thyroid storm, CHF.
    • Hypothyroidism in pregnancy: Levothyroxine is category A, first-line treatment. Dosage significantly increases; monitor serum TSH.
    • Hyperthyroidism in pregnancy: Propylthiouracil (PTU) is often preferred due to lower transfer to the fetus. Both PTU and Methimazole are category D. Both are safe for breastfeeding.
    • Screening: Postpartum depression suggests checking TSH; also check for thyroid dysfunction if symptoms are present. 5% of women have thyroid disorders postpartum.

    Testosterone Deficiency

    • Primary: Testicular origin; Secondary: Hypothalamus-pituitary dysfunction.
    • Common in men >45 years old, increasing due to aging population.
    • Diagnosis: Total testosterone <300 ng/dL after two separate early morning measurements, combined with symptoms/signs.
    • Causes: Aging, injury, infection, loss of testicles, cancer treatment, genetic abnormalities, hormone treatments for prostate cancer, corticosteroids.
    • Additional testing considerations: Unexplained anemia, bone density loss, diabetes, chemotherapy/radiation exposure, HIV/AIDS, chronic narcotic use, male infertility, pituitary dysfunction, and chronic corticosteroid use in the absence of symptoms.
    • Reproductive evaluation before testosterone therapy for men with testosterone deficiency who are interested in fertility.
    • Measured hemoglobin/hematocrit before therapy, and PSA in men over 40.
    • Uncertain impact of therapy on cardiovascular events.
    • Comorbidities: Metabolic syndrome, diabetes, cardiovascular disease, hypertension, COPD, autoimmune diseases.
    • Black box warning: Secondary virilization in children, avoid contact with topical testosterone application sites. Blood pressure increases and may increase risk of major adverse CV events and pulmonary microembolism reactions.
    • Risks and benefits of therapy: Improved quality of life (libido, mood, bone/muscle mass). Limited well-controlled studies. May lower blood sugar in diabetics.
    • Adverse effects: Worsening sleep apnea, gynecomastia, acne, accelerated male pattern baldness, erythrocytosis, prostate cancer, metastatic progression, decreased spermatogenesis, fertility issues, increased cardiovascular risk.
    • Contraindications: Prostate/breast cancer.
    • Warnings/Precautions: Long-term use risk of breast cancer (if parenteral). May alter serum lipid profiles (use caution with history of MI within 3 months or coronary artery disease.) Avoid in patients with cardiovascular disease.
    • Testing: Measure testosterone every 6-12 months.

    Erectile Dysfunction

    • Persistent inability to maintain and sustain an erection for sexual intercourse.
    • Occasional ED is normal, frequent occurrences may signal underlying health issues.
    • Often a combination of emotional and physical factors.
    • Risk marker for cardiovascular disease.
    • Measurement of morning total testosterone to rule out low testosterone.
    • Conditions associated with ED: Cardiovascular disease, high blood pressure, obesity, low testosterone/hormone imbalances, age, stress, anxiety, depression.
    • Erection mechanism: Sexual stimulation releases nitric oxide, dilating blood vessels in corpus cavernosum. Accumulation of cyclic GMP dilates vessels. Enzyme PDE5 breaks down cGMP leading to erection resolution.
    • Treatment: Primarily pharmacological (PDE5 inhibitors).
    • PDE5 Inhibitors:
      • Relaxation of smooth muscle, inflow of blood, increasing corpus cavernosum dilation.
      • Reduce smooth muscle, endothelial cell proliferation, nerve activity, increase smooth muscle relaxation and tissue perfusion of the prostate and bladder. - Possible adverse effects: Headache, dyspepsia, flushing, gastritis, priapism, myalgias, abnormal vision, elevated LFTs. - Metabolism: CYP450 system (CYP3A4). Caution with other CYP3A4 substrates (grapefruit juice). - Potential drug interactions: Potentiate hypotensive effects of nitrates, alpha-blockers, and other antihypertensives. CYP3A4 inhibitors increase plasma levels, and CYP3A4 inducers (like rifampin) reduce levels. - Contraindications: Concurrent use of nitrates. - Precautions: Cardiovascular disease.
      • Patient education: Take 1 hr before intercourse, maximum once-daily use. Not affected by alcohol (although alcohol can cause ED).
      • Enhanced with testosterone therapy (when low testosterone is a factor.)

    Benign Prostatic Hyperplasia

    • Enlarged prostate gland, common in aging males.
    • Urinary symptoms: Frequent/urgent urination, increased nighttime urination (nocturia), difficulty starting urination, weak or interrupted urine stream, dribbling.
    • Severity doesn't correlate with size.
    • Some potential stabilization or symptom improvement over time.
    • Treatments:
      • Medications, minimally invasive therapies, or surgery.
      • Alpha-1 blockers: Relax bladder, neck, and prostate muscles, making urination easier.
        • Tamsulosin (Flomax) is a common example.
        • Quick effect in men with smaller prostates (improvement in 48 hours to one week).
        • Symptom relief for up to 4 years if used alone, doesn't shrink the prostate
        • Adverse effects: Hypotension, fatigue, prolonged erection, atrial fibrillation
      • 5-alpha-reductase inhibitors: (blocking dihydrotestosterone); shrink the prostate, increase urine flow
        • Takes 3-6 months.
        • Adverse effects: Impotence (4%), allergic reactions, breast or high-grade prostate cancer, decreased libido, abnormal ejaculation; gynecomastia, dizziness or lightheadedness.

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    Description

    This quiz covers key concepts related to thyroid disorders, including hyperthyroidism and hypothyroidism. Learn about the causes, symptoms, and types of these disorders, especially Grave's Disease and Hashimoto's thyroiditis. Test your knowledge on how thyroid hormones impact the body.

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