Podcast
Questions and Answers
What is the role of cortical epithelial cells in the thymus?
What is the role of cortical epithelial cells in the thymus?
- Provide antigens to pre-T lymphocytes for negative selection
- Serve as a tight layer around the microvasculature in the medulla
- Directly bind with mature T lymphocytes for selection
- Secrete cytokines that promote T-cell maturation (correct)
Where do mature T lymphocytes exit the thymus from?
Where do mature T lymphocytes exit the thymus from?
- Venules and efferent lymphatics in the medulla (correct)
- Cortical epithelial cells in the cortex
- Capsules surrounding the thymus
- Tight junctions between thymic epithelial cells
What happens to pre-T lymphocytes that recognize self-antigens during thymic selection?
What happens to pre-T lymphocytes that recognize self-antigens during thymic selection?
- Die by apoptosis (correct)
- Advance to the thymic cortex
- Differentiate into mature T lymphocytes
- Undergo negative selection by dendritic cells
Which cell population begins to proliferate in the thymic cortex?
Which cell population begins to proliferate in the thymic cortex?
What is the purpose of positive selection in the thymus?
What is the purpose of positive selection in the thymus?
What determines whether a pre-T lymphocyte will survive and advance to the thymic medulla?
What determines whether a pre-T lymphocyte will survive and advance to the thymic medulla?
What is the main function of squamous cortical TECs?
What is the main function of squamous cortical TECs?
What characterizes the thymic medulla in terms of lymphocytes?
What characterizes the thymic medulla in terms of lymphocytes?
What is the function of Hassall corpuscles in the thymic medulla?
What is the function of Hassall corpuscles in the thymic medulla?
What distinguishes primary nodules from secondary nodules in lymphoid nodules?
What distinguishes primary nodules from secondary nodules in lymphoid nodules?
Which type of medullary TECs supports T lymphocytes, dendritic cells, and macrophages?
Which type of medullary TECs supports T lymphocytes, dendritic cells, and macrophages?
What is the unique feature of thymic corpuscles?
What is the unique feature of thymic corpuscles?
What is the main function of squamous thymic epithelial cells in the cortex of the thymus?
What is the main function of squamous thymic epithelial cells in the cortex of the thymus?
What is the function of stellate thymic epithelial cells in the cortex of the thymus?
What is the function of stellate thymic epithelial cells in the cortex of the thymus?
Which cells in the cortex of the thymus are responsible for secreting IL-4 and other cytokines that stimulate gene recombination of B cells?
Which cells in the cortex of the thymus are responsible for secreting IL-4 and other cytokines that stimulate gene recombination of B cells?
What role do squamous thymic epithelial cells play in maintaining the blood-thymus barrier?
What role do squamous thymic epithelial cells play in maintaining the blood-thymus barrier?
Which characteristic distinguishes stellate thymic epithelial cells from squamous TECs?
Which characteristic distinguishes stellate thymic epithelial cells from squamous TECs?
Why are cortical epithelial cells in the thymus considered as antigen-presenting cells (APCs)?
Why are cortical epithelial cells in the thymus considered as antigen-presenting cells (APCs)?
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