Thrombosis and Thromboembolism VCS 84610 Quiz

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Questions and Answers

What are the factors that contribute to the formation of arterial thrombosis?

  • Stagnant flow and fibrin-rich/platelet-poor embolus
  • High-shear flow and platelet-rich thrombus (correct)
  • Enhanced thrombolysis and reduced platelet function
  • Reduced clotting factors and excessive clotting factors

Which type of thrombosis involves a thrombus forming at a distant site from the original clot location?

  • Venous Thromboembolism (VTE/PE) (correct)
  • Arterial Thrombosis (AT)
  • Venous Thrombosis (DVT)
  • Arterial Thromboembolism (ATE)

According to Virchow’s Triangle, which factor is one of the contributors to thrombosis?

  • Endothelial injury
  • Blood stasis (correct)
  • Enhanced thrombolysis
  • Reduced platelet function

What is unique about the composition of an embolus in arterial thromboembolism?

<p>Fibrin-rich/platelet-poor embolus (A)</p> Signup and view all the answers

Which type of thrombosis involves a thrombus that may form at the site of vascular injury?

<p>Venous Thrombosis (DVT) (D)</p> Signup and view all the answers

What is the significance of hypercoagulability in the physiology of thrombosis?

<p>It increases the risk of clot formation (D)</p> Signup and view all the answers

What is the primary mechanism of action of aspirin as an antiplatelet drug?

<p>Inhibits cyclooxygenase (D)</p> Signup and view all the answers

Which breed of cat has the highest relative risk for hypercoagulability?

<p>Maine Coon (C)</p> Signup and view all the answers

What is the primary effect of low molecular weight heparins (LMWHs) on coagulation?

<p>Inhibit factor Xa (B)</p> Signup and view all the answers

Which of the following is NOT a potential sequelae of aortic trifurcation embolism in cats?

<p>Hematuria (B)</p> Signup and view all the answers

What is the recommended initial dosage of clopidogrel for dogs with cardiogenic embolism?

<p>10 mg/kg PO at presentation (B)</p> Signup and view all the answers

Which of the following is a potential clinical sign of pulmonary embolism in dogs?

<p>Vomiting and diarrhea (B)</p> Signup and view all the answers

What should be considered to reduce continued thrombus formation in the acute management of cardiogenic embolism?

<p>Begin anticoagulation with LMWH (B)</p> Signup and view all the answers

What is the most common cause of death in the acute period of cardiogenic embolism?

<p>Reperfusion injury (C)</p> Signup and view all the answers

Which factor does aspirin NOT affect in its mechanism of action as an antiplatelet drug?

<p>Protein C activation (B)</p> Signup and view all the answers

Which anticoagulant has high variability in pharmacodynamic response and requires monitoring with PT/INR?

<p>Warfarin (B)</p> Signup and view all the answers

What is a characteristic feature of arterial thrombosis?

<p>High-shear flow (A)</p> Signup and view all the answers

Which factor contributes to the physiology of thrombosis according to Virchow's Triangle?

<p>Hypercoagulability (A)</p> Signup and view all the answers

What is a key difference between venous thrombosis and arterial thrombosis?

<p>Fibrin-rich/platelet-poor embolus in venous thrombosis (A)</p> Signup and view all the answers

What type of thromboembolism involves an embolus obstructing a normal vessel at a distant site?

<p>Arterial Thromboembolism (ATE) (B)</p> Signup and view all the answers

Which condition is associated with reduced regulation of clotting factors?

<p>Excessive clotting factors (C)</p> Signup and view all the answers

What is the primary mechanism of action of clopidogrel as an antiplatelet drug?

<p>Antagonizes ADP receptors (C)</p> Signup and view all the answers

Which breed of cat has the second-highest relative risk for hypercoagulability according to the provided text?

<p>Tonkinese (C)</p> Signup and view all the answers

What is the primary effect of vitamin K antagonists like warfarin on coagulation factors?

<p>Inhibits Factor II (B)</p> Signup and view all the answers

Which of the following clinical conditions is NOT associated with platelet hyperreactivity according to the text?

<p>Hyperadrenocorticism (D)</p> Signup and view all the answers

Which anticoagulant does NOT primarily inhibit thrombin (IIa) but instead primarily inhibits Xa through ATIII?

<p>Low Molecular Weight Heparins (LMWH) (B)</p> Signup and view all the answers

What are the primary sequelae of aortic trifurcation (saddle thrombus) embolism in cats?

<p>Ischemic neuromyopathy and pulmonary embolism (D)</p> Signup and view all the answers

What is the recommended initial dosage of enoxaparin, a Low Molecular Weight Heparin (LMWH), in dogs for thrombosis treatment?

<p>1 mg/kg SQ q 12-24 hr (D)</p> Signup and view all the answers

What is the primary complication that can result from a sudden resumption in blood flow to ischemic tissues, known as reperfusion injury?

<p>Tissue necrosis (A)</p> Signup and view all the answers

What is a potential treatment option to increase collateral flow in cats with cardiogenic embolism?

<p>Nitroglycerine ointment (B)</p> Signup and view all the answers

What is one significant difference between clopidogrel and aspirin as antiplatelet drugs based on the text?

<p>Clopidogrel has no effect on thromboxane A2 production while aspirin does. (A)</p> Signup and view all the answers

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