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What defining characteristic distinguishes bullous pemphigoid from other skin disorders?

Presence of pruritic urticarial lesions

Exclusively affecting individuals below 60 years old

Development of blisters only on the mucous membranes

Formation of subepidermal blisters with eosinophils (correct)

Which treatment is commonly used for managing bullous pemphigoid?

Antihistamines only

Topical antibiotics

Glucocorticoids and immunosuppressives (correct)

Surgery to remove affected areas

What is the usual age range for the onset of bullous pemphigoid?

60 to 80 years (correct)

30 to 50 years

Over 80 years only

20 to 40 years

Which autoantibodies are primarily associated with bullous pemphigoid?

Anti-basement membrane IgG autoantibodies Signup and view all the answers

In which anatomical sites is bullous pemphigoid most likely to present?

Axillae and thighs Signup and view all the answers

What primarily compensates for the loss of Dsg 1 function in the deep epidermis and mucous membranes?

Dsg 3 Signup and view all the answers

What is the incidence of bullous pemphigoid reported in Germany and France?

Seven per million Signup and view all the answers

What type of lesions are initially produced in bullous pemphigoid before they collapse?

Tense bullae Signup and view all the answers

In which condition are antibodies present only against Dsg 3, leading to blisters in the deep mucous membrane?

Pemphigus vulgaris Signup and view all the answers

What causes the blister formation in muco-cutaneous pemphigus?

Antibodies against Dsg 1 and Dsg 3 Signup and view all the answers

What symptom is commonly experienced by individuals with bullous pemphigoid?

Intense itching (pruritus) Signup and view all the answers

Which sign indicates the dislodging of epidermis resulting in erosion during pemphigus testing?

Nikolsky sign Signup and view all the answers

Which of the following drugs is commonly associated with drug-induced pemphigus?

Captopril Signup and view all the answers

In paraneoplastic pemphigus, which areas are most severely affected?

Mucous membranes Signup and view all the answers

What typically happens to the skin eruption after the termination of therapy with the offending drug in drug-induced pemphigus?

It resolves Signup and view all the answers

Which statement accurately describes the lesions found in paraneoplastic pemphigus?

They combine features of pemphigus vulgaris and erythema multiforme Signup and view all the answers

What characteristic finding is observed in the early lesions of pemphigus vulgaris?

Separation of keratinocytes suprabasally Signup and view all the answers

What is a common feature found in direct immunofluorescence staining of pemphigus vulgaris lesions?

Presence of C3 in the intercellular substance Signup and view all the answers

Which variant of pemphigus vulgaris is characterized by granulomatous vegetating purulent plaques?

Pemphigus Vegetans Signup and view all the answers

Which autoimmune mechanism is primarily responsible for the lesions seen in pemphigus vulgaris?

Autoantibodies against desmoglein 3 Signup and view all the answers

Which drug is most commonly associated with inducing pemphigus vulgaris?

Captopril Signup and view all the answers

What histopathological feature is rarely seen in pemphigus vulgaris due to its superficial location?

Flaccid bulla formation Signup and view all the answers

Which technique is used to detect serum autoantibodies in pemphigus vulgaris?

Enzyme-linked immunosorbent assay (ELISA) Signup and view all the answers

What distinguishes drug-induced pemphigus from sporadic pemphigus vulgaris?

Association with specific drugs Signup and view all the answers

What type of lesions result from the interaction of bioactive molecules released from inflammatory cells?

Bullous lesions Signup and view all the answers

What is one of the primary components involved in the pathogenesis of the bullous lesions mentioned?

Hemidesmosomes Signup and view all the answers

Which immune cells are attracted to the site of the bullous lesion according to the content?

Neutrophils Signup and view all the answers

In which layer does the junctional cleavage occur in the context of bullous lesions?

Lamina lucida Signup and view all the answers

Which of the following autoantibodies interacts with the bullous pemphigoid antigens?

IgG Signup and view all the answers

What type of alignment is observed for neutrophils in this condition?

Indian-file alignment Signup and view all the answers

What is less likely to rupture compared to pemphigus according to the content?

Bullous pemphigoid Signup and view all the answers

Which histological feature characterizes bullous pemphigoid lesions?

Subepithelial bulla Signup and view all the answers

What type of lesion often precedes bullae formation in the described condition?

Urticarial lesions Signup and view all the answers

Which autoantibody is associated with the 230-kDa glycoprotein in bullous pemphigoid?

BPAG1 Signup and view all the answers

Which of the following symptoms is typically NOT associated with early stage bullous pemphigoid?

Constitutional symptoms Signup and view all the answers

What type of hematological finding can be present in bullous pemphigoid?

Eosinophilia Signup and view all the answers

What is the function of BPAG2 in the context of bullous pemphigoid?

Part of hemidesmosomes Signup and view all the answers

Clinical manifestations of bullous pemphigoid first appear as which kind of eruption?

Prodromal eruption Signup and view all the answers

The detection of IgG antibodies in bullous pemphigoid occurs in what percentage of patients?

70% Signup and view all the answers

What is true about the correlation between antibody titers and disease course in bullous pemphigoid?

Titers do not correlate with course of disease Signup and view all the answers

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Questions and Answers

What defining characteristic distinguishes bullous pemphigoid from other skin disorders?

Which treatment is commonly used for managing bullous pemphigoid?

What is the usual age range for the onset of bullous pemphigoid?

Which autoantibodies are primarily associated with bullous pemphigoid?

In which anatomical sites is bullous pemphigoid most likely to present?

What primarily compensates for the loss of Dsg 1 function in the deep epidermis and mucous membranes?

What is the incidence of bullous pemphigoid reported in Germany and France?

What type of lesions are initially produced in bullous pemphigoid before they collapse?

In which condition are antibodies present only against Dsg 3, leading to blisters in the deep mucous membrane?

What causes the blister formation in muco-cutaneous pemphigus?

What symptom is commonly experienced by individuals with bullous pemphigoid?

Which sign indicates the dislodging of epidermis resulting in erosion during pemphigus testing?

Which of the following drugs is commonly associated with drug-induced pemphigus?

In paraneoplastic pemphigus, which areas are most severely affected?

What typically happens to the skin eruption after the termination of therapy with the offending drug in drug-induced pemphigus?

Which statement accurately describes the lesions found in paraneoplastic pemphigus?

What characteristic finding is observed in the early lesions of pemphigus vulgaris?

What is a common feature found in direct immunofluorescence staining of pemphigus vulgaris lesions?

Which variant of pemphigus vulgaris is characterized by granulomatous vegetating purulent plaques?

Which autoimmune mechanism is primarily responsible for the lesions seen in pemphigus vulgaris?

Which drug is most commonly associated with inducing pemphigus vulgaris?

What histopathological feature is rarely seen in pemphigus vulgaris due to its superficial location?

Which technique is used to detect serum autoantibodies in pemphigus vulgaris?

What distinguishes drug-induced pemphigus from sporadic pemphigus vulgaris?

What type of lesions result from the interaction of bioactive molecules released from inflammatory cells?

What is one of the primary components involved in the pathogenesis of the bullous lesions mentioned?

Which immune cells are attracted to the site of the bullous lesion according to the content?

In which layer does the junctional cleavage occur in the context of bullous lesions?

Which of the following autoantibodies interacts with the bullous pemphigoid antigens?

What type of alignment is observed for neutrophils in this condition?

What is less likely to rupture compared to pemphigus according to the content?

Which histological feature characterizes bullous pemphigoid lesions?

What type of lesion often precedes bullae formation in the described condition?

Which autoantibody is associated with the 230-kDa glycoprotein in bullous pemphigoid?

Which of the following symptoms is typically NOT associated with early stage bullous pemphigoid?

What type of hematological finding can be present in bullous pemphigoid?

What is the function of BPAG2 in the context of bullous pemphigoid?

Clinical manifestations of bullous pemphigoid first appear as which kind of eruption?

The detection of IgG antibodies in bullous pemphigoid occurs in what percentage of patients?

What is true about the correlation between antibody titers and disease course in bullous pemphigoid?

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