Podcast
Questions and Answers
Which of the following is a way in which infections may contribute to autoimmunity?
Which of the following is a way in which infections may contribute to autoimmunity?
What is the term used to describe the cross-reactions between microbial and self antigens?
What is the term used to describe the cross-reactions between microbial and self antigens?
Which cytokine has been associated with the development of several autoimmune diseases, including lupus?
Which cytokine has been associated with the development of several autoimmune diseases, including lupus?
Which of the following is an example of a disorder where antibodies produced against a microbial protein bind to self proteins?
Which of the following is an example of a disorder where antibodies produced against a microbial protein bind to self proteins?
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What is the postulated mechanism for the development of autoimmune diseases associated with periodontal bacterial infections?
What is the postulated mechanism for the development of autoimmune diseases associated with periodontal bacterial infections?
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What may influence the health of the immune system and the maintenance of self-tolerance?
What may influence the health of the immune system and the maintenance of self-tolerance?
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What is a trigger for the development of the autoimmune disease SLE?
What is a trigger for the development of the autoimmune disease SLE?
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Study Notes
Infections and Autoimmunity
- Infections can trigger autoimmunity through molecular mimicry, where the immune system mistakenly targets self antigens due to similarities with microbial antigens.
- Cross-reactions between microbial and self antigens are termed "molecular mimicry."
Cytokines and Autoimmune Diseases
- Interferon-gamma is a cytokine associated with the development of several autoimmune diseases, particularly systemic lupus erythematosus (lupus).
Antibody Disorders
- An example of a disorder with antibodies against microbial proteins binding to self proteins is rheumatic fever, where streptococcal antibodies can cross-react with cardiac tissue.
Periodontal Bacteria and Autoimmunity
- The postulated mechanism for autoimmune diseases related to periodontal bacterial infections includes the release of bacterial antigens that can provoke an autoimmune response against host tissues.
Immune System Health and Self-Tolerance
- Factors influencing immune system health and maintenance of self-tolerance include genetic predisposition, environmental triggers, and the overall microbiome composition.
Triggers for Specific Autoimmune Diseases
- A significant trigger for systemic lupus erythematosus (SLE) is exposure to ultraviolet (UV) light, which can initiate a cascade of immune responses leading to disease onset.
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Description
Understanding the Link Between Infections and Autoimmune Diseases: Test your knowledge on how infections can activate self-reactive lymphocytes and contribute to the development of autoimmune diseases. Explore the association between infections and autoimmune tissue injury in this informative quiz.
