The Infection-Autoimmune Connection

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Which of the following is a way in which infections may contribute to autoimmunity?

Infections may break T cell tolerance

What is the term used to describe the cross-reactions between microbial and self antigens?

Molecular mimicry

Which cytokine has been associated with the development of several autoimmune diseases, including lupus?

Type I interferon

Which of the following is an example of a disorder where antibodies produced against a microbial protein bind to self proteins?

Rheumatic fever

What is the postulated mechanism for the development of autoimmune diseases associated with periodontal bacterial infections?

Inflammatory responses leading to enzymatic conversion of arginines to citrullines in self proteins

What may influence the health of the immune system and the maintenance of self-tolerance?

Normal variations in the microbiome of humans

What is a trigger for the development of the autoimmune disease SLE?

Exposure to sunlight

Understanding the Link Between Infections and Autoimmune Diseases: Test your knowledge on how infections can activate self-reactive lymphocytes and contribute to the development of autoimmune diseases. Explore the association between infections and autoimmune tissue injury in this informative quiz.

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