Podcast
Questions and Answers
What is the speaker's profession?
What is the speaker's profession?
- Consultant
- Surgeon
- Acute physician (correct)
- Endocrinologist
What is the main focus of the speaker's talk?
What is the main focus of the speaker's talk?
- Exploring the causes of unconscious bias
- Promoting a specific weight loss program
- Advocating for empathy towards people living in bigger bodies (correct)
- Discussing the technical aspects of bariatric surgery
What is the correct term used to refer to individuals with obesity according to the speaker?
What is the correct term used to refer to individuals with obesity according to the speaker?
- Overweight person
- Obesity sufferer
- Obese individual
- Person living with obesity (correct)
Where does Dr. Satish Parthasarathy work?
Where does Dr. Satish Parthasarathy work?
What will be explored in the first part of the talk?
What will be explored in the first part of the talk?
What is the speaker's advice regarding the duration of the session?
What is the speaker's advice regarding the duration of the session?
What are the main topics covered by the speaker in the talk?
What are the main topics covered by the speaker in the talk?
How does the speaker suggest obesity should be understood?
How does the speaker suggest obesity should be understood?
What does the audience prompt to consider regarding individuals living with obesity?
What does the audience prompt to consider regarding individuals living with obesity?
How is obesity discussed in the talk?
How is obesity discussed in the talk?
What is highlighted as impacting judgments and perceptions in the talk?
What is highlighted as impacting judgments and perceptions in the talk?
What does the speaker suggest implicit bias can lead to?
What does the speaker suggest implicit bias can lead to?
Which method for measuring body composition is mentioned as potentially inaccurate in very large individuals?
Which method for measuring body composition is mentioned as potentially inaccurate in very large individuals?
What is the BMI category for class three obesity?
What is the BMI category for class three obesity?
What is a potential implication of societal views on who should receive healthcare, as mentioned in the text?
What is a potential implication of societal views on who should receive healthcare, as mentioned in the text?
What is the prevalence of obesity among men and women in the UK, as stated in the text?
What is the prevalence of obesity among men and women in the UK, as stated in the text?
What does the text suggest about the use of BMI in assessing metabolic health?
What does the text suggest about the use of BMI in assessing metabolic health?
What is the potential influence on obesity prevalence mentioned in the text?
What is the potential influence on obesity prevalence mentioned in the text?
What impact does public attitudes towards obesity have?
What impact does public attitudes towards obesity have?
Why do people struggle to identify when someone is obese despite increasing obesity rates?
Why do people struggle to identify when someone is obese despite increasing obesity rates?
What is a consequence of healthcare policies disqualifying obese individuals from certain treatments?
What is a consequence of healthcare policies disqualifying obese individuals from certain treatments?
Why does research into obesity receive less funding than HIV and digestive diseases despite high prevalence?
Why does research into obesity receive less funding than HIV and digestive diseases despite high prevalence?
What is a consequence of internalized stigma and shame associated with obesity?
What is a consequence of internalized stigma and shame associated with obesity?
Why do healthcare professionals need to address bias and advocate for policies that address the social and healthcare inequalities associated with obesity?
Why do healthcare professionals need to address bias and advocate for policies that address the social and healthcare inequalities associated with obesity?
What has led to a significant shift in the way we consume calories?
What has led to a significant shift in the way we consume calories?
How much has sugar consumption in places like Congo increased due to globalization and westernization?
How much has sugar consumption in places like Congo increased due to globalization and westernization?
What did a study look at related to obesity and find strong correlations in certain areas?
What did a study look at related to obesity and find strong correlations in certain areas?
What did overfeeding studies on male twins show about weight gain?
What did overfeeding studies on male twins show about weight gain?
What did calorie restriction studies reveal about weight loss?
What did calorie restriction studies reveal about weight loss?
What highlights the complex interplay between globalization, genetic factors, and obesity?
What highlights the complex interplay between globalization, genetic factors, and obesity?
What percentage of people in UK society believe that 'most overweight people could lose weight if they tried'?
What percentage of people in UK society believe that 'most overweight people could lose weight if they tried'?
What percentage of people in UK society feel that a very overweight person would be less likely to be offered a manager job?
What percentage of people in UK society feel that a very overweight person would be less likely to be offered a manager job?
What do explicit bias and implicit bias reflect in the context of obesity bias?
What do explicit bias and implicit bias reflect in the context of obesity bias?
What is a potential reason for the bias against people living in larger bodies?
What is a potential reason for the bias against people living in larger bodies?
What is the common perception about why most overweight people cannot lose weight, according to the text?
What is the common perception about why most overweight people cannot lose weight, according to the text?
What do the beliefs about weight loss and job opportunities in the UK society suggest about societal attitudes?
What do the beliefs about weight loss and job opportunities in the UK society suggest about societal attitudes?
What does the text imply about the challenges of addressing implicit bias?
What does the text imply about the challenges of addressing implicit bias?
What is the prevailing belief about overweight people's ability to lose weight, according to the text?
What is the prevailing belief about overweight people's ability to lose weight, according to the text?
What is the main focus of the talk?
What is the main focus of the talk?
What is the potential implication of societal views on healthcare, as mentioned in the text?
What is the potential implication of societal views on healthcare, as mentioned in the text?
What is the correct term used to refer to individuals with obesity according to the speaker?
What is the correct term used to refer to individuals with obesity according to the speaker?
What is highlighted as impacting judgments and perceptions in the talk?
What is highlighted as impacting judgments and perceptions in the talk?
Why do healthcare professionals need to address bias and advocate for policies that address the social and healthcare inequalities associated with obesity?
Why do healthcare professionals need to address bias and advocate for policies that address the social and healthcare inequalities associated with obesity?
What did the speaker suggest implicit bias can lead to?
What did the speaker suggest implicit bias can lead to?
What is a consequence of internalized stigma and shame associated with obesity?
What is a consequence of internalized stigma and shame associated with obesity?
What is the BMI category for class three obesity?
What is the BMI category for class three obesity?
Which of the following comorbidities is NOT associated with obesity?
Which of the following comorbidities is NOT associated with obesity?
What is the BMI range for class three obesity?
What is the BMI range for class three obesity?
What is the most common type of cancer associated with obesity?
What is the most common type of cancer associated with obesity?
What is the term used to refer to individuals with obesity according to the speaker?
What is the term used to refer to individuals with obesity according to the speaker?
At what BMI range does life expectancy decrease as BMI increases?
At what BMI range does life expectancy decrease as BMI increases?
Which of the following is a potential consequence of internalized stigma and shame associated with obesity?
Which of the following is a potential consequence of internalized stigma and shame associated with obesity?
What is the relative risk of death associated with obesity, as indicated by the text?
What is the relative risk of death associated with obesity, as indicated by the text?
What is the BMI category for class three obesity?
What is the BMI category for class three obesity?
What data was the Prospective Studies Collaboration based on?
What data was the Prospective Studies Collaboration based on?
What is the main aim of obesity treatment?
What is the main aim of obesity treatment?
What is the impact of adiposity and fat distribution on metabolic health?
What is the impact of adiposity and fat distribution on metabolic health?
What factors contribute to the increased risk of Type 2 diabetes (T2DM)?
What factors contribute to the increased risk of Type 2 diabetes (T2DM)?
What are the BMI categories for overweight and obesity?
What are the BMI categories for overweight and obesity?
Which closely associated cardiovascular risk factors are included in metabolic syndrome?
Which closely associated cardiovascular risk factors are included in metabolic syndrome?
What is the incremental cost-effectiveness ratio of metabolic surgery for BMI ≥40 over 20 years?
What is the incremental cost-effectiveness ratio of metabolic surgery for BMI ≥40 over 20 years?
What is the primary composite outcome in the time-to-event analysis for GLP1 receptor agonists?
What is the primary composite outcome in the time-to-event analysis for GLP1 receptor agonists?
What is the BMI threshold recommended by NICE for expedited bariatric surgery for those with recent onset T2DM?
What is the BMI threshold recommended by NICE for expedited bariatric surgery for those with recent onset T2DM?
Which pharmacotherapy drug has specific licensing criteria and is known as Victoza for T2DM treatment and Saxenda for obesity?
Which pharmacotherapy drug has specific licensing criteria and is known as Victoza for T2DM treatment and Saxenda for obesity?
What is a potential complication of metabolic surgery mentioned in the text?
What is a potential complication of metabolic surgery mentioned in the text?
What percentage of patients with Type 2 Diabetes Mellitus achieved 15 kg weight loss or more with Very Low Calorie Diets (VLCD)?
What percentage of patients with Type 2 Diabetes Mellitus achieved 15 kg weight loss or more with Very Low Calorie Diets (VLCD)?
What is the long-term adherence to lifestyle changes challenging due to, according to the text?
What is the long-term adherence to lifestyle changes challenging due to, according to the text?
What is the minimum duration of engagement with a non-surgical weight-loss programme required before considering surgery?
What is the minimum duration of engagement with a non-surgical weight-loss programme required before considering surgery?
What is a potential problem with Tier 3 weight management services?
What is a potential problem with Tier 3 weight management services?
What was Emily's weight at the age of 12?
What was Emily's weight at the age of 12?
What procedure did Emily undergo at the age of 21?
What procedure did Emily undergo at the age of 21?
What was Emily's weight after starting Liraglutide treatment in November 2021?
What was Emily's weight after starting Liraglutide treatment in November 2021?
What was the duration of engagement with the Tier 3 service before Emily had revision surgery?
What was the duration of engagement with the Tier 3 service before Emily had revision surgery?
What mutation was found in Emily, leading to loss of function?
What mutation was found in Emily, leading to loss of function?
What type of weight management service did St Richards Integrated Bariatric Service provide?
What type of weight management service did St Richards Integrated Bariatric Service provide?
What did Emily undergo in October 2020 before starting Liraglutide treatment?
What did Emily undergo in October 2020 before starting Liraglutide treatment?
What is the tiered approach to weight management services mentioned in the text?
What is the tiered approach to weight management services mentioned in the text?
What mutation did Emily have, as mentioned in the text?
What mutation did Emily have, as mentioned in the text?
At what age did Emily undergo a privately fitted laparoscopic gastric band?
At what age did Emily undergo a privately fitted laparoscopic gastric band?
What was the result of Emily's use of Liraglutide?
What was the result of Emily's use of Liraglutide?
What is emphasized as effective communication about weight in the text?
What is emphasized as effective communication about weight in the text?
According to the text, what is a requirement before surgery as per NHS England 2013 guidelines?
According to the text, what is a requirement before surgery as per NHS England 2013 guidelines?
What did Emily's case study demonstrate, as mentioned in the text?
What did Emily's case study demonstrate, as mentioned in the text?
What does Emily's personal success story reflect, as mentioned in the text?
What does Emily's personal success story reflect, as mentioned in the text?
What does Emily's journey highlight, as mentioned in the text?
What does Emily's journey highlight, as mentioned in the text?
Study Notes
The Impact of Globalization and Genetic Factors on Obesity
- Globalization and westernization have led to a significant shift in the way we consume calories, with easy access to non-locally produced food.
- This adaptive behavior has resulted in a 20% increase in brain volume compared to apes, due to expanded access to sugar, oil, crops, and animal products.
- Sugar consumption in places like Congo has increased by nearly 850% due to globalization and westernization.
- There has been a 36% change in the average way people consume calories globally.
- Obesity is genetically mediated in part, with studies exploring the heritability of obesity and the impact of single nucleotide polymorphisms (SNPs).
- There are approximately 6 million SNPs that can influence disease processes or normal behavior in people.
- A study looked at 2.1 million SNPs related to obesity and found strong correlations in certain areas.
- Around 140 SNPs related to obesity were identified, and an obesity risk score was calculated based on the number of SNPs.
- Different genes contribute to waist-to-hip ratio and brain function, but SNPs play a significant role in polygenic obesity.
- Overfeeding studies on male twins showed that weight gain was driven by genetic makeup, with minimal variation within twin pairs.
- Calorie restriction studies also revealed that weight loss was similarly influenced by genetic factors, with minimal variation within twin pairs.
- These findings highlight the complex interplay between globalization, genetic factors, and obesity, emphasizing the need for further research and understanding.
Weight Loss Interventions for Type 2 Diabetes
- Very Low Calorie Diets (VLCD) for patients with Type 2 Diabetes Mellitus (T2DM) show promising results with 24% achieving 15 kg weight loss or more and 46% inducing remission of T2DM.
- Long-term adherence to lifestyle changes is challenging, with the larger weight loss making maintenance harder.
- Pharmacotherapy options such as Orlistat and GLP1 receptor agonists like Liraglutide and Semaglutide have shown positive effects on weight and diabetes prevention.
- Metabolic surgery, previously known as bariatric surgery, has been found to help patients live longer and maintain weight loss, with incremental cost-effectiveness ratios of £2000 - £4000 per QALY over 20 years for BMI ≥40.
- Roux-en-Y gastric bypass and Sleeve gastrectomy are effective surgical options, each with specific benefits and risks.
- Metabolic surgery can treat T2DM, reduce BMI and HbA1C, and decrease the need for diabetes medications.
- However, metabolic surgery comes with several potential complications, including nutrient deficiencies, dumping syndrome, hypoglycemia, and significant nutritional disturbance.
- NICE recommends expedited bariatric surgery for those with recent onset T2DM and BMI >35, and to consider surgery for those with BMI >30, specifically lowering BMI by 2.5 points for high-risk populations.
- NHS England has a position statement on bariatric/metabolic surgery, with specific criteria for eligibility and consideration as a first-line treatment for those with a BMI >50 kg/m2.
- The primary composite outcome in the time-to-event analysis for GLP1 receptor agonists was the first occurrence of death from cardiovascular causes, non-fatal myocardial infarction, or non-fatal stroke.
- GLP1 receptor agonists like Liraglutide, also known as Victoza for T2DM treatment and Saxenda for obesity, are effective at low and high doses, with specific licensing criteria.
- Pharmacotherapy drugs like Orlistat and GLP1 receptor agonists have shown positive effects on weight and diabetes prevention, with specific dosing and licensing criteria.
Challenges in Weight Management Services and a Personal Success Story
- NHS England 2013 guidelines require 5 years of obesity and a 12-24 month non-surgical weight-loss program before surgery
- The tiered approach to weight management services includes Semaglutide/Wegovy and Liraglutide/Saxenda
- Issues with Tier 3 services include variable provision, outcomes, structure, and engagement length
- Tier 3 providers may have limited medical input in deciding surgery referrals
- West Sussex and South Coast Tier 3 services have varying durations and limited medical assessments
- Effective communication about weight requires an empathetic, respectful, and collaborative approach
- Emily's case study demonstrates abnormal weight gain from childhood, multiple medical interventions, and genetic testing
- Emily underwent a privately fitted laparoscopic gastric band at age 21 and was referred to Tier 3 service at age 22
- Emily had a GPR10 mutation and underwent revision surgery to bypass and started Liraglutide, resulting in a 17% weight loss
- Emily's personal success story reflects a significant change in her life and acceptance of her weight
- Emily's journey highlights the complex and multifaceted nature of weight management and the importance of personalized care
- The challenges and successes in weight management services underscore the need for comprehensive and individualized approaches.
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Description
Test your knowledge on the impact of globalization and genetic factors on obesity with this quiz. Explore the influence of global food consumption patterns, genetic predispositions, and the interplay between nature and nurture in the development of obesity.
