PATH Pathology of the Ovary
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Questions and Answers

Which is the most common histologic type of ovarian neoplasm?

  • Serous (correct)
  • Endometrioid
  • Clear cell
  • Mucinous

Which ovarian neoplasm is associated with endometriosis?

  • Clear cell
  • Serous
  • Mucinous
  • Endometrioid (correct)

Which ovarian neoplasm is most commonly associated with BRCA1 and BRCA2 germline mutations?

  • Mucinous
  • Serous (correct)
  • Endometrioid
  • Clear cell

Which ovarian neoplasm is most commonly associated with KRAS mutations?

<p>Mucinous (B)</p> Signup and view all the answers

Which ovarian neoplasm is most commonly associated with PTEN, CTNBB1, and ARIDA1 mutations?

<p>Endometrioid (C)</p> Signup and view all the answers

Which ovarian neoplasm is associated with anti-NMDA receptor encephalitis?

<p>Mature teratoma (D)</p> Signup and view all the answers

Which ovarian neoplasm is the ovarian counterpart to testicular seminoma?

<p>Dysgerminoma (B)</p> Signup and view all the answers

Which ovarian neoplasm is characterized by large vesicular cells with clear cytoplasm, well-defined cell borders, and centrally-placed nuclei, arranged in nests/cords, separated by fibrous septa containing lymphocytes or granulomatous inflammation?

<p>Dysgerminoma (C)</p> Signup and view all the answers

Which ovarian neoplasm is most commonly associated with mature tissue types (ectoderm, mesoderm, and endoderm)?

<p>Mature teratoma (C)</p> Signup and view all the answers

Which ovarian neoplasm is the primary mucinous ovarian carcinoma a rare subtype of?

<p>Mucinous (D)</p> Signup and view all the answers

Which tumor is derived from extraembryonic yolk sac structures and may show elevated serum alpha feta protein (AFP)?

<p>Yolk sac (endodermal sinus tumor) (B)</p> Signup and view all the answers

Which tumor is derived from extraembryonic trophoblastic structures and may show elevated serum beta-hCG?

<p>Nongestational choriocarcinoma (A)</p> Signup and view all the answers

Which tumor is derived from ovarian stroma and sex cords of the embryonic gonad?

<p>Fibroma/Thecoma/Fibrothecoma (A)</p> Signup and view all the answers

Which of the following tumor types does NOT usually have hormonal effects?

<p>Yolk sac (endodermal sinus tumor) (C)</p> Signup and view all the answers

Which tumor type is associated with Meigs syndrome and Basal nevus (Gorlin) syndrome?

<p>Fibroma/Thecoma/Fibrothecoma (B)</p> Signup and view all the answers

Which tumor type is often androgen-secreting and can cause virilization, hirsutism, and voice changes?

<p>Sertoli-Leydig (D)</p> Signup and view all the answers

Which tumor is the most common site of metastasis within the gynecologic tract?

<p>Metastasis to Ovary (C)</p> Signup and view all the answers

Which tumor type refers to bilateral ovarian masses composed of mucinous signet ring cells, usually of gastric origin?

<p>Krukenberg Tumor (C)</p> Signup and view all the answers

Which tumor type resembles developing ovarian follicles and may have elevated serum estrogen and systemic symptoms of hyperestrogenic state?

<p>Granulosa cell tumor (A)</p> Signup and view all the answers

Which tumor type is characterized by sheets of atypical trophoblasts and is extremely rare, most commonly seen as a component in mixed germ cell tumors?

<p>Nongestational choriocarcinoma (D)</p> Signup and view all the answers

Which one of the following is a characteristic of the follicular phase of the ovarian cycle?

<p>The ovaries produce a single dominant follicle selected for ovulation. (C)</p> Signup and view all the answers

Which one of the following is a characteristic of the luteal phase of the ovarian cycle?

<p>The remaining granulosa cells of the follicle transform into corpus luteum. (D)</p> Signup and view all the answers

Which one of the following is a characteristic of menarche?

<p>The first ovarian cycle at puberty. (B)</p> Signup and view all the answers

Which one of the following is a characteristic of menopause?

<p>Cessation of the ovarian cycle. (B)</p> Signup and view all the answers

Which one of the following is a characteristic of Polycystic Ovarian Syndrome (PCOS)?

<p>Androgen excess, ovulatory dysfunction, and polycystic ovaries. (A)</p> Signup and view all the answers

Which one of the following is a characteristic of the pathophysiology of PCOS? (Other 3 are a result of it or features of PCOS)

<p>Persistently elevated LH leads to absence of LH surge, and therefore, absence of ovulation. (C)</p> Signup and view all the answers

Which one of the following is a characteristic of the role of LH in the ovarian cycle?

<p>Ovulation is stimulated by an LH surge. (A)</p> Signup and view all the answers

Which one of the following is a characteristic of the role of FSH in the ovarian cycle?

<p>Granulosa cells secrete estrogen under the influence of FSH. (C)</p> Signup and view all the answers

Which one of the following is a characteristic of the role of theca cells in the ovarian cycle?

<p>Theca cells secrete androgens under the influence of LH. (C)</p> Signup and view all the answers

Which one of the following is a characteristic of the role of granulosa cells in the ovarian cycle?

<p>Granulosa cells secrete estrogen under the influence of FSH. (D)</p> Signup and view all the answers

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