PATH Pathology of the Ovary

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Which is the most common histologic type of ovarian neoplasm?

Serous (correct)

Endometrioid

Clear cell

Mucinous

Which ovarian neoplasm is associated with endometriosis?

Clear cell

Serous

Mucinous

Endometrioid (correct)

Which ovarian neoplasm is most commonly associated with BRCA1 and BRCA2 germline mutations?

Mucinous

Serous (correct)

Endometrioid

Clear cell

Which ovarian neoplasm is most commonly associated with KRAS mutations?

Mucinous Signup and view all the answers

Which ovarian neoplasm is most commonly associated with PTEN, CTNBB1, and ARIDA1 mutations?

Endometrioid Signup and view all the answers

Which ovarian neoplasm is associated with anti-NMDA receptor encephalitis?

Mature teratoma Signup and view all the answers

Which ovarian neoplasm is the ovarian counterpart to testicular seminoma?

Dysgerminoma Signup and view all the answers

Which ovarian neoplasm is characterized by large vesicular cells with clear cytoplasm, well-defined cell borders, and centrally-placed nuclei, arranged in nests/cords, separated by fibrous septa containing lymphocytes or granulomatous inflammation?

Dysgerminoma Signup and view all the answers

Which ovarian neoplasm is most commonly associated with mature tissue types (ectoderm, mesoderm, and endoderm)?

Mature teratoma Signup and view all the answers

Which ovarian neoplasm is the primary mucinous ovarian carcinoma a rare subtype of?

Mucinous Signup and view all the answers

Which tumor is derived from extraembryonic yolk sac structures and may show elevated serum alpha feta protein (AFP)?

Yolk sac (endodermal sinus tumor) Signup and view all the answers

Which tumor is derived from extraembryonic trophoblastic structures and may show elevated serum beta-hCG?

Nongestational choriocarcinoma Signup and view all the answers

Which tumor is derived from ovarian stroma and sex cords of the embryonic gonad?

Fibroma/Thecoma/Fibrothecoma Signup and view all the answers

Which of the following tumor types does NOT usually have hormonal effects?

Yolk sac (endodermal sinus tumor) Signup and view all the answers

Which tumor type is associated with Meigs syndrome and Basal nevus (Gorlin) syndrome?

Fibroma/Thecoma/Fibrothecoma Signup and view all the answers

Which tumor type is often androgen-secreting and can cause virilization, hirsutism, and voice changes?

Sertoli-Leydig Signup and view all the answers

Which tumor is the most common site of metastasis within the gynecologic tract?

Metastasis to Ovary Signup and view all the answers

Which tumor type refers to bilateral ovarian masses composed of mucinous signet ring cells, usually of gastric origin?

Krukenberg Tumor Signup and view all the answers

Which tumor type resembles developing ovarian follicles and may have elevated serum estrogen and systemic symptoms of hyperestrogenic state?

Granulosa cell tumor Signup and view all the answers

Which tumor type is characterized by sheets of atypical trophoblasts and is extremely rare, most commonly seen as a component in mixed germ cell tumors?

Nongestational choriocarcinoma Signup and view all the answers

Which one of the following is a characteristic of the follicular phase of the ovarian cycle?

The ovaries produce a single dominant follicle selected for ovulation. Signup and view all the answers

Which one of the following is a characteristic of the luteal phase of the ovarian cycle?

The remaining granulosa cells of the follicle transform into corpus luteum. Signup and view all the answers

Which one of the following is a characteristic of menarche?

The first ovarian cycle at puberty. Signup and view all the answers

Which one of the following is a characteristic of menopause?

Cessation of the ovarian cycle. Signup and view all the answers

Which one of the following is a characteristic of Polycystic Ovarian Syndrome (PCOS)?

Androgen excess, ovulatory dysfunction, and polycystic ovaries. Signup and view all the answers

Which one of the following is a characteristic of the pathophysiology of PCOS? (Other 3 are a result of it or features of PCOS)

Persistently elevated LH leads to absence of LH surge, and therefore, absence of ovulation. Signup and view all the answers

Which one of the following is a characteristic of the role of LH in the ovarian cycle?

Ovulation is stimulated by an LH surge. Signup and view all the answers

Which one of the following is a characteristic of the role of FSH in the ovarian cycle?

Granulosa cells secrete estrogen under the influence of FSH. Signup and view all the answers

Which one of the following is a characteristic of the role of theca cells in the ovarian cycle?

Theca cells secrete androgens under the influence of LH. Signup and view all the answers

Which one of the following is a characteristic of the role of granulosa cells in the ovarian cycle?

Granulosa cells secrete estrogen under the influence of FSH. Signup and view all the answers

PATH Pathology of the Ovary

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Questions and Answers

Which is the most common histologic type of ovarian neoplasm?

Which ovarian neoplasm is associated with endometriosis?

Which ovarian neoplasm is most commonly associated with BRCA1 and BRCA2 germline mutations?

Which ovarian neoplasm is most commonly associated with KRAS mutations?

Which ovarian neoplasm is most commonly associated with PTEN, CTNBB1, and ARIDA1 mutations?

Which ovarian neoplasm is associated with anti-NMDA receptor encephalitis?

Which ovarian neoplasm is the ovarian counterpart to testicular seminoma?

Which ovarian neoplasm is characterized by large vesicular cells with clear cytoplasm, well-defined cell borders, and centrally-placed nuclei, arranged in nests/cords, separated by fibrous septa containing lymphocytes or granulomatous inflammation?

Which ovarian neoplasm is most commonly associated with mature tissue types (ectoderm, mesoderm, and endoderm)?

Which ovarian neoplasm is the primary mucinous ovarian carcinoma a rare subtype of?

Which tumor is derived from extraembryonic yolk sac structures and may show elevated serum alpha feta protein (AFP)?

Which tumor is derived from extraembryonic trophoblastic structures and may show elevated serum beta-hCG?

Which tumor is derived from ovarian stroma and sex cords of the embryonic gonad?

Which of the following tumor types does NOT usually have hormonal effects?

Which tumor type is associated with Meigs syndrome and Basal nevus (Gorlin) syndrome?

Which tumor type is often androgen-secreting and can cause virilization, hirsutism, and voice changes?

Which tumor is the most common site of metastasis within the gynecologic tract?

Which tumor type refers to bilateral ovarian masses composed of mucinous signet ring cells, usually of gastric origin?

Which tumor type resembles developing ovarian follicles and may have elevated serum estrogen and systemic symptoms of hyperestrogenic state?

Which tumor type is characterized by sheets of atypical trophoblasts and is extremely rare, most commonly seen as a component in mixed germ cell tumors?

Which one of the following is a characteristic of the follicular phase of the ovarian cycle?

Which one of the following is a characteristic of the luteal phase of the ovarian cycle?

Which one of the following is a characteristic of menarche?

Which one of the following is a characteristic of menopause?

Which one of the following is a characteristic of Polycystic Ovarian Syndrome (PCOS)?

Which one of the following is a characteristic of the pathophysiology of PCOS? (Other 3 are a result of it or features of PCOS)

Which one of the following is a characteristic of the role of LH in the ovarian cycle?

Which one of the following is a characteristic of the role of FSH in the ovarian cycle?

Which one of the following is a characteristic of the role of theca cells in the ovarian cycle?

Which one of the following is a characteristic of the role of granulosa cells in the ovarian cycle?

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