Podcast
Questions and Answers
What is the primary function of follicular cells in the thyroid gland?
What is the primary function of follicular cells in the thyroid gland?
What triggers the release of thyroid hormones into the bloodstream?
What triggers the release of thyroid hormones into the bloodstream?
Which condition may be indicated by high levels of TSH along with low levels of T3 and T4?
Which condition may be indicated by high levels of TSH along with low levels of T3 and T4?
What role do thyroid-binding globulins (TBGs) play in the endocrine system?
What role do thyroid-binding globulins (TBGs) play in the endocrine system?
Signup and view all the answers
Which hormone stimulates active transport of iodine molecules into the thyroid follicles?
Which hormone stimulates active transport of iodine molecules into the thyroid follicles?
Signup and view all the answers
What happens to the thyroid follicles when there is a decrease or absence of TSH?
What happens to the thyroid follicles when there is a decrease or absence of TSH?
Signup and view all the answers
Which autoimmune disorder is associated with hyperthyroidism?
Which autoimmune disorder is associated with hyperthyroidism?
Signup and view all the answers
What substance is primarily produced by the extrafollicular cells in the thyroid gland?
What substance is primarily produced by the extrafollicular cells in the thyroid gland?
Signup and view all the answers
What role does calcitonin (CT) play in calcium homeostasis?
What role does calcitonin (CT) play in calcium homeostasis?
Signup and view all the answers
Which of the following hormones is produced by chief cells in the parathyroid glands?
Which of the following hormones is produced by chief cells in the parathyroid glands?
Signup and view all the answers
How does the body respond when blood calcium levels increase?
How does the body respond when blood calcium levels increase?
Signup and view all the answers
What effect does PTH have on the kidneys?
What effect does PTH have on the kidneys?
Signup and view all the answers
What is the primary function of calcitriol in relation to calcium levels?
What is the primary function of calcitriol in relation to calcium levels?
Signup and view all the answers
Where are the parathyroid glands located in relation to the thyroid?
Where are the parathyroid glands located in relation to the thyroid?
Signup and view all the answers
What characteristic gives the adrenal cortex a yellow appearance?
What characteristic gives the adrenal cortex a yellow appearance?
Signup and view all the answers
What is the role of osteoclasts in calcium homeostasis?
What is the role of osteoclasts in calcium homeostasis?
Signup and view all the answers
Which cells respond directly to increased calcium levels in the blood?
Which cells respond directly to increased calcium levels in the blood?
Signup and view all the answers
What is the function of the adrenal cortex?
What is the function of the adrenal cortex?
Signup and view all the answers
What is the primary function of Antidiuretic Hormone (ADH)?
What is the primary function of Antidiuretic Hormone (ADH)?
Signup and view all the answers
What is the normal fasting glucose level in mg/dL?
What is the normal fasting glucose level in mg/dL?
Signup and view all the answers
Which hormone is responsible for the maturation and production of sperm in males?
Which hormone is responsible for the maturation and production of sperm in males?
Signup and view all the answers
What is a characteristic of Type 1 diabetes?
What is a characteristic of Type 1 diabetes?
Signup and view all the answers
What triggers the release of Oxytocin (OT) during childbirth?
What triggers the release of Oxytocin (OT) during childbirth?
Signup and view all the answers
Which hormone is produced by the pineal gland?
Which hormone is produced by the pineal gland?
Signup and view all the answers
Which hormone is released in response to gall bladder contraction and milk ejection?
Which hormone is released in response to gall bladder contraction and milk ejection?
Signup and view all the answers
What physiological process does melatonin primarily regulate?
What physiological process does melatonin primarily regulate?
Signup and view all the answers
What condition is characterized by a lack of Antidiuretic Hormone (ADH) production?
What condition is characterized by a lack of Antidiuretic Hormone (ADH) production?
Signup and view all the answers
What hormone stimulates the breakdown of triglycerides in fat tissue?
What hormone stimulates the breakdown of triglycerides in fat tissue?
Signup and view all the answers
What condition is indicated by the presence of glucose in urine?
What condition is indicated by the presence of glucose in urine?
Signup and view all the answers
Which hormone increases the sensitivity of interstitial cells of the testes to Luteinizing Hormone (ICSH)?
Which hormone increases the sensitivity of interstitial cells of the testes to Luteinizing Hormone (ICSH)?
Signup and view all the answers
Diabetes Type 2 is most commonly associated with which of the following?
Diabetes Type 2 is most commonly associated with which of the following?
Signup and view all the answers
What role does Melanocyte Stimulating Hormone (MSH) play in the body?
What role does Melanocyte Stimulating Hormone (MSH) play in the body?
Signup and view all the answers
Which of the following organs has a secondary endocrine function?
Which of the following organs has a secondary endocrine function?
Signup and view all the answers
What does HbA1C measure?
What does HbA1C measure?
Signup and view all the answers
Which hormone is often described as having diabetogenic effects?
Which hormone is often described as having diabetogenic effects?
Signup and view all the answers
How does the posterior pituitary differ from the anterior pituitary?
How does the posterior pituitary differ from the anterior pituitary?
Signup and view all the answers
What effect can the elimination of melatonin have on puberty?
What effect can the elimination of melatonin have on puberty?
Signup and view all the answers
What is a significant risk of uncontrolled diabetes mellitus?
What is a significant risk of uncontrolled diabetes mellitus?
Signup and view all the answers
What role does calcitriol play in the body?
What role does calcitriol play in the body?
Signup and view all the answers
How do ANP and BNP affect blood pressure?
How do ANP and BNP affect blood pressure?
Signup and view all the answers
Which hormone is needed for normal levels of GnRH and gonadotropin synthesis?
Which hormone is needed for normal levels of GnRH and gonadotropin synthesis?
Signup and view all the answers
What effect does high fructose corn syrup have on leptin?
What effect does high fructose corn syrup have on leptin?
Signup and view all the answers
What is one of the functions of calcitriol concerning the kidneys?
What is one of the functions of calcitriol concerning the kidneys?
Signup and view all the answers
What triggers the release of natriuretic peptides such as ANP and BNP?
What triggers the release of natriuretic peptides such as ANP and BNP?
Signup and view all the answers
What is the impact of leptin on appetite?
What is the impact of leptin on appetite?
Signup and view all the answers
What is the primary effect of calcitriol suppressing PTH production?
What is the primary effect of calcitriol suppressing PTH production?
Signup and view all the answers
What characterizes positive feedback mechanisms?
What characterizes positive feedback mechanisms?
Signup and view all the answers
Which process is an example of positive feedback in the human body?
Which process is an example of positive feedback in the human body?
Signup and view all the answers
In the context of blood clotting, what initiates the positive feedback loop?
In the context of blood clotting, what initiates the positive feedback loop?
Signup and view all the answers
During childbirth, how does oxytocin function as part of the positive feedback mechanism?
During childbirth, how does oxytocin function as part of the positive feedback mechanism?
Signup and view all the answers
What happens to the release of chemicals promoting platelet movement once the vessel injury is repaired?
What happens to the release of chemicals promoting platelet movement once the vessel injury is repaired?
Signup and view all the answers
How does a severe cut affect blood pressure and cardiac efficiency?
How does a severe cut affect blood pressure and cardiac efficiency?
Signup and view all the answers
What triggers the positive feedback loop during blood clotting?
What triggers the positive feedback loop during blood clotting?
Signup and view all the answers
What is the first signal in the positive feedback loop during labor?
What is the first signal in the positive feedback loop during labor?
Signup and view all the answers
Flashcards
Positive Feedback
Positive Feedback
A mechanism that amplifies or enhances an initial change in a physiological system, leading to a more rapid and extreme response.
Homeostasis
Homeostasis
A set of interconnected physiological processes that maintain a stable internal environment within the body, despite external changes.
Positive Feedback & Blood Clotting
Positive Feedback & Blood Clotting
The process of blood clotting, where the initial formation of a clot triggers the release of clotting factors, ultimately leading to a stable clot.
Positive Feedback & Labor
Positive Feedback & Labor
Signup and view all the flashcards
Positive Feedback & Breastfeeding
Positive Feedback & Breastfeeding
Signup and view all the flashcards
Thyroid gland
Thyroid gland
Signup and view all the flashcards
Thyroid follicles
Thyroid follicles
Signup and view all the flashcards
Follicular cells
Follicular cells
Signup and view all the flashcards
Thyroglobulin
Thyroglobulin
Signup and view all the flashcards
T3 and T4 (Triiodothyronine and Thyroxine)
T3 and T4 (Triiodothyronine and Thyroxine)
Signup and view all the flashcards
Extrafollicular cells
Extrafollicular cells
Signup and view all the flashcards
TSH (Thyroid Stimulating Hormone)
TSH (Thyroid Stimulating Hormone)
Signup and view all the flashcards
Thyroid-binding Globulins (TBGs)
Thyroid-binding Globulins (TBGs)
Signup and view all the flashcards
Somatotropin (GH)
Somatotropin (GH)
Signup and view all the flashcards
IGFs (Insulin-like Growth Factors)
IGFs (Insulin-like Growth Factors)
Signup and view all the flashcards
Follitropin (FSH)
Follitropin (FSH)
Signup and view all the flashcards
Lutropin (LH)
Lutropin (LH)
Signup and view all the flashcards
Mammotropin (PRL)
Mammotropin (PRL)
Signup and view all the flashcards
Pars Intermedia
Pars Intermedia
Signup and view all the flashcards
Posterior Pituitary
Posterior Pituitary
Signup and view all the flashcards
Antidiuretic Hormone (ADH)
Antidiuretic Hormone (ADH)
Signup and view all the flashcards
Oxytocin (OT)
Oxytocin (OT)
Signup and view all the flashcards
Hypothalamic-Pituitary Axis
Hypothalamic-Pituitary Axis
Signup and view all the flashcards
What is homeostasis?
What is homeostasis?
Signup and view all the flashcards
What is calcitonin?
What is calcitonin?
Signup and view all the flashcards
What are C cells?
What are C cells?
Signup and view all the flashcards
What is osteolysis?
What is osteolysis?
Signup and view all the flashcards
What are chief cells?
What are chief cells?
Signup and view all the flashcards
What is parathyroid hormone (PTH)?
What is parathyroid hormone (PTH)?
Signup and view all the flashcards
What is calcitriol?
What is calcitriol?
Signup and view all the flashcards
What is the adrenal cortex?
What is the adrenal cortex?
Signup and view all the flashcards
What are corticosteroids?
What are corticosteroids?
Signup and view all the flashcards
What are transcortins?
What are transcortins?
Signup and view all the flashcards
Islets of Langerhans
Islets of Langerhans
Signup and view all the flashcards
Hyperglycemia
Hyperglycemia
Signup and view all the flashcards
HbA1C
HbA1C
Signup and view all the flashcards
Diabetes mellitus
Diabetes mellitus
Signup and view all the flashcards
Type 1 diabetes
Type 1 diabetes
Signup and view all the flashcards
Type 2 diabetes
Type 2 diabetes
Signup and view all the flashcards
Gluconeogenesis
Gluconeogenesis
Signup and view all the flashcards
Thymosins
Thymosins
Signup and view all the flashcards
Pinealocytes
Pinealocytes
Signup and view all the flashcards
Melatonin
Melatonin
Signup and view all the flashcards
Parathyroid Hormone (PTH)
Parathyroid Hormone (PTH)
Signup and view all the flashcards
Calcitriol
Calcitriol
Signup and view all the flashcards
Atrial Natriuretic Peptide (ANP)
Atrial Natriuretic Peptide (ANP)
Signup and view all the flashcards
Ghrelin
Ghrelin
Signup and view all the flashcards
Leptin
Leptin
Signup and view all the flashcards
Negative Feedback
Negative Feedback
Signup and view all the flashcards
Study Notes
The Endocrine System
- Homeostasis is a state of chemical and thermal balance, maintaining a stable internal environment.
- Nervous and endocrine systems maintain homeostasis.
- Endocrine system is responsible for long-term processes like growth, development, and reproduction.
- Nervous system manages rapid communication and split-second responses.
- The neuroendocrine response is a combined action of both systems maintaining homeostasis.
- Endocrine system communicates through hormones released directly into the bloodstream and ECF (extracellular fluid).
- Target cells have specific receptors to bind and interpret hormones.
- Hormones change the type, amount, and activity of enzymes and proteins, influencing responses to internal and external changes in the environment.
Classes of Hormones
- Amino acid derivatives are derived from tyrosine and tryptophan, including thyroid hormone and catecholamines (epinephrine, norepinephrine, and dopamine). Melatonin is a primary tryptophan derivative.
- Peptide hormones are chains of amino acids, often activated before or after secretion. Glycoproteins have carbohydrate chains, while other small polypeptides and proteins are shorter chains.
- Lipid derivatives include eicosanoids (leukotrienes, prostaglandins, thromboxanes, and prostacyclins) as well as steroid hormones (structurally similar to cholesterol). Steroids are typically bound to transport proteins in the blood.
Mechanisms of Hormone Action
- Hormones interact with specific receptors on target cells.
- The number and type of receptors determine a cell's sensitivity to a hormone.
- Lipid-soluble hormones (steroids and eicosanoids) cross the plasma membrane to bind intracellular receptors, affecting gene expression directly.
- Water-soluble hormones (catecholamines and peptides) bind to receptors on the cell surface, activating second messenger systems.
- Second messenger systems, like cyclic AMP or calcium ions, amplify the signal and create effects within the cell.
Indirect Effects of Hormones
- Hormone-receptor binding on the cell surface activates a G protein, which can activate other enzymes like adenylate cyclase.
- Adenylate cyclase converts ATP to cyclic AMP (cAMP), a second messenger.
- cAMP activates protein kinases that phosphorylate other proteins, leading to cellular responses.
- Hormone binding to a different receptor type activates the enzyme phospholipase C (PLC), ultimately increasing calcium levels in the cell.
- Calcium acts as another second messenger, activating enzymes and altering cellular functions.
Direct Effects of Hormones (Steroids)
- Steroid hormones diffuse through the cell membrane.
- Hormones bind to receptors in the cytoplasm or nucleus of the target cell.
- Hormone-receptor complexes bind to DNA, activating or deactivating specific genes, changing transcription and protein synthesis.
- This affects the target cell's metabolic activity and structure.
Direct Effects of Hormones (TH) - Thyroid Hormones
- Thyroid hormones cross the plasma membrane and bind to receptors in the nucleus.
- Hormone-receptor complexes activate certain genes, influencing the rate of transcription.
- Metabolic activity is altered through changes in enzyme concentrations within cells, particularly in mitochondria that increase ATP production.
Modulation of Target Cell Sensitivity
- Cells can adjust sensitivity to hormones by changing receptor numbers.
- Up-regulation increases receptor numbers, making the cell more sensitive to a hormone.
- Down-regulation decreases receptor numbers, making the cell less sensitive to a hormone.
- Factors like high hormone concentrations and/or diseases lead to down-regulation or up-regulation.
Control of Hormones Negative Feedback
- Negative feedback: homeostasis is maintained through the regulation of hormone amounts in response to fluctuations.
- Endocrine glands adjust hormone production in response to changes in their concentrations.
- Declining hormone levels trigger increased hormone production; rising levels trigger inhibition of hormone production.
Negative Feedback Loop Example
- Hypothalamus releases TRH.
- Anterior pituitary releases TSH.
- Thyroid releases T3 and T4.
- Rising T3 and T4 levels inhibit the release of TRH and TSH.
- Maintaining a stable output of hormones.
Positive Feedback Loop Examples
- Childbirth – uterine contractions. Positive feedback reinforces the stimulus.
- Blood clotting – platelets aggregate to stop bleeding. Positive feedback accelerates the process until homeostasis is reached
The Pituitary Gland
- AKA the master gland, it controls/influences many other glands.
- Three main parts: anterior lobe, posterior lobe, and intermediate.
- Anterior lobe (adenohypophysis) - makes and releases its hormones (tropic hormones).
- Posterior lobe (neurohypophysis) - stores and releases hypothalamic hormones (ADH & OT).
- Intermediate lobe (pars intermedia) - produces melanocyte-stimulating hormone (MSH).
Anterior Pituitary
- Composed of 5 cell types: -Thyrotropes (TSH) – thyroid stimulating hormone
- Corticotropes (ACTH) – adrenal cortex stimulating hormone. -Gonadotropes (FSH & LH) – follicle-stimulating hormone and luteinizing hormone.
- Somatotropes (GH)- growth hormone.
- Mamotropes (PRL) – prolactin
Posterior Pituitary
- Stores and releases Antidiuretic hormone (ADH) and Oxytocin (OT).
- No hormones are synthesised in the posterior lobe.
Hormones of the Adrenal Glands
- Adrenal cortex (3 zones): zona glomerulosa, zona fasciculata, zona reticularis
- Mineralocorticoids (zona glomerulosa) – regulation of mineral balance, especially sodium (aldosterone).
- Glucocorticoids (zona fasciculata) – carbohydrate and protein metabolism, stress response (cortisol).
- Gonadocorticoids (zona reticularis) – small amounts; conversion to sex hormones
Adrenal Medulla
- Produces epinephrine and norepinephrine (fight-or-flight response).
- Sympathetic Nervous System stimulation leads to increased release of these hormones.
- Increased blood glucose, fatty acid mobilization, increased cardiac rate, and elevated blood pressure.
Pancreas
- Both exocrine and endocrine functions
- Exocrine function: 99% of acini—produce alkaline pancreatic juice with digestive enzymes
- Endocrine function: islets of Langerhans (~2 million cells).
- Alpha cells: produce glucagon
- Beta cells: produce insulin
- Delta cells: produce somatostatin
- F Cells: produce pancreatic polypeptide
Diabetes
- Type 1 diabetes: characterized by inadequate insulin production by pancreatic beta cells.
- Type 2 diabetes: tissues don't respond properly to insulin.
- Both types lead to elevated blood glucose levels.
Secondary Endocrine Functions
- Intestines: hormones for digestive control.
- Kidneys: erythropoietin (EPO), calcitriol, renin.
- Heart: atrial natriuretic peptides (ANP) and brain natriuretic peptide (BNP).
- Thymus: thymosins (T lymphocyte development).
- Gonads: hormones for reproduction.
Hormonal Interactions
- Antagonistic hormones: have opposing effects (e.g., calcitonin and parathyroid hormone).
- Synergistic hormones: have additive effects (e.g., glucose sparing of GH and glucocorticoids).
- Permissive hormones: 1 hormone is needed for another to exert its effect (e.g., TH is needed for full effects of epinephrine).
- Integrative hormones: different hormones in different tissues work together in combination (e.g., calcitriol and PTH).
General Adaptation Syndrome (GAS)
- Three phases of stress response: alarm, resistance, exhaustion.
- Alarm phase: immediate response involving epinephrine and norepinephrine.
- Resistance phase: longer-term response with increased glucocorticoid levels.
- Exhaustion phase: body reserves are depleted, and homeostasis cannot be maintained.
Additional Topics
- Pineal gland: produces melatonin involved in circadian rhythms and regulates reproductive function also related to the color of the skin.
- Kidney Function: Kidney produces renin to help regulate water and electrolyte balance.
- Hypothalamic-Pituitary Axis: Hypothalamus regulates the anterior pituitary gland.
- Hypophyseal Portal System: Specialized blood vessels connecting the hypothalamus and anterior pituitary to allow hormones rapid movement with limited dilution.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Explore the functions of the endocrine system and its role in maintaining homeostasis. Learn about different classes of hormones and how they interact with target cells. Understand the importance of hormonal balance in growth, development, and reproduction.