The Endocrine System Overview
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Questions and Answers

What is the primary function of follicular cells in the thyroid gland?

  • Storage of thyroid hormones
  • Secretion of calcitonin
  • Regulation of blood calcium levels
  • Production of thyroid hormones (correct)
  • What triggers the release of thyroid hormones into the bloodstream?

  • Increased levels of parathyroid hormone
  • Increase in body temperature
  • Release of thyroid-stimulating hormone (TSH) (correct)
  • Introduction of iodine in the diet
  • Which condition may be indicated by high levels of TSH along with low levels of T3 and T4?

  • Thyroiditis
  • Thyroid cancer
  • Hypothyroidism (correct)
  • Hyperthyroidism
  • What role do thyroid-binding globulins (TBGs) play in the endocrine system?

    <p>They bind and release thyroid hormones as needed. (C)</p> Signup and view all the answers

    Which hormone stimulates active transport of iodine molecules into the thyroid follicles?

    <p>Thyroid-Stimulating Hormone (TSH) (A)</p> Signup and view all the answers

    What happens to the thyroid follicles when there is a decrease or absence of TSH?

    <p>They become inactive. (B)</p> Signup and view all the answers

    Which autoimmune disorder is associated with hyperthyroidism?

    <p>Grave’s disease (D)</p> Signup and view all the answers

    What substance is primarily produced by the extrafollicular cells in the thyroid gland?

    <p>Calcitonin (B)</p> Signup and view all the answers

    What role does calcitonin (CT) play in calcium homeostasis?

    <p>It inhibits osteoclasts and promotes bone formation. (D)</p> Signup and view all the answers

    Which of the following hormones is produced by chief cells in the parathyroid glands?

    <p>Parathyroid Hormone (PTH) (C)</p> Signup and view all the answers

    How does the body respond when blood calcium levels increase?

    <p>Calcitonin is released from C cells. (C)</p> Signup and view all the answers

    What effect does PTH have on the kidneys?

    <p>It promotes calcium reabsorption. (D)</p> Signup and view all the answers

    What is the primary function of calcitriol in relation to calcium levels?

    <p>It enhances intestinal absorption of calcium. (D)</p> Signup and view all the answers

    Where are the parathyroid glands located in relation to the thyroid?

    <p>Embedded in the posterior thyroid. (D)</p> Signup and view all the answers

    What characteristic gives the adrenal cortex a yellow appearance?

    <p>The accumulation of lipids. (D)</p> Signup and view all the answers

    What is the role of osteoclasts in calcium homeostasis?

    <p>Release calcium into the bloodstream. (C)</p> Signup and view all the answers

    Which cells respond directly to increased calcium levels in the blood?

    <p>C cells of the thyroid gland. (C)</p> Signup and view all the answers

    What is the function of the adrenal cortex?

    <p>Secretion of corticosteroids. (D)</p> Signup and view all the answers

    What is the primary function of Antidiuretic Hormone (ADH)?

    <p>Decrease water loss (C)</p> Signup and view all the answers

    What is the normal fasting glucose level in mg/dL?

    <p>70-99 (D)</p> Signup and view all the answers

    Which hormone is responsible for the maturation and production of sperm in males?

    <p>Follitropin (A)</p> Signup and view all the answers

    What is a characteristic of Type 1 diabetes?

    <p>Inadequate insulin production (A)</p> Signup and view all the answers

    What triggers the release of Oxytocin (OT) during childbirth?

    <p>A sudden rise in OT (A)</p> Signup and view all the answers

    Which hormone is produced by the pineal gland?

    <p>Melatonin (D)</p> Signup and view all the answers

    Which hormone is released in response to gall bladder contraction and milk ejection?

    <p>Oxytocin (C)</p> Signup and view all the answers

    What physiological process does melatonin primarily regulate?

    <p>Circadian rhythms (D)</p> Signup and view all the answers

    What condition is characterized by a lack of Antidiuretic Hormone (ADH) production?

    <p>Diabetes insipidus (B)</p> Signup and view all the answers

    What hormone stimulates the breakdown of triglycerides in fat tissue?

    <p>Somatotropin (A)</p> Signup and view all the answers

    What condition is indicated by the presence of glucose in urine?

    <p>Diabetes mellitus (D)</p> Signup and view all the answers

    Which hormone increases the sensitivity of interstitial cells of the testes to Luteinizing Hormone (ICSH)?

    <p>Prolactin (C)</p> Signup and view all the answers

    Diabetes Type 2 is most commonly associated with which of the following?

    <p>Obesity (A)</p> Signup and view all the answers

    What role does Melanocyte Stimulating Hormone (MSH) play in the body?

    <p>Increases production of melanin (D)</p> Signup and view all the answers

    Which of the following organs has a secondary endocrine function?

    <p>Thymus (B)</p> Signup and view all the answers

    What does HbA1C measure?

    <p>Average blood glucose over 3 months (D)</p> Signup and view all the answers

    Which hormone is often described as having diabetogenic effects?

    <p>Somatotropin (C)</p> Signup and view all the answers

    How does the posterior pituitary differ from the anterior pituitary?

    <p>It stores and releases hormones (B)</p> Signup and view all the answers

    What effect can the elimination of melatonin have on puberty?

    <p>Cause premature puberty (A)</p> Signup and view all the answers

    What is a significant risk of uncontrolled diabetes mellitus?

    <p>Diabetic ketoacidosis (D)</p> Signup and view all the answers

    What role does calcitriol play in the body?

    <p>Stimulates absorption of calcium and phosphate in the digestive tract (C)</p> Signup and view all the answers

    How do ANP and BNP affect blood pressure?

    <p>They promote sodium and water loss, decreasing blood pressure (B)</p> Signup and view all the answers

    Which hormone is needed for normal levels of GnRH and gonadotropin synthesis?

    <p>Leptin (D)</p> Signup and view all the answers

    What effect does high fructose corn syrup have on leptin?

    <p>It decreases leptin release, preventing a feeling of satiation (C)</p> Signup and view all the answers

    What is one of the functions of calcitriol concerning the kidneys?

    <p>It stimulates calcium reabsorption (D)</p> Signup and view all the answers

    What triggers the release of natriuretic peptides such as ANP and BNP?

    <p>Increased blood volume and atrial wall stretch (C)</p> Signup and view all the answers

    What is the impact of leptin on appetite?

    <p>It provides a sense of satiation (D)</p> Signup and view all the answers

    What is the primary effect of calcitriol suppressing PTH production?

    <p>Regulation of calcium homeostasis (D)</p> Signup and view all the answers

    What characterizes positive feedback mechanisms?

    <p>They become more intense during dangerous situations. (D)</p> Signup and view all the answers

    Which process is an example of positive feedback in the human body?

    <p>Breastfeeding (D)</p> Signup and view all the answers

    In the context of blood clotting, what initiates the positive feedback loop?

    <p>The release of chemicals from damaged blood vessels. (C)</p> Signup and view all the answers

    During childbirth, how does oxytocin function as part of the positive feedback mechanism?

    <p>It enhances contractions of smooth muscles in the uterus. (A)</p> Signup and view all the answers

    What happens to the release of chemicals promoting platelet movement once the vessel injury is repaired?

    <p>It decreases, leading to a reduction in platelet accumulation. (C)</p> Signup and view all the answers

    How does a severe cut affect blood pressure and cardiac efficiency?

    <p>It decreases blood pressure and cardiac efficiency. (C)</p> Signup and view all the answers

    What triggers the positive feedback loop during blood clotting?

    <p>The arrival of platelets at the injury site. (B)</p> Signup and view all the answers

    What is the first signal in the positive feedback loop during labor?

    <p>Pressure from the fetal head on the cervix. (D)</p> Signup and view all the answers

    Flashcards

    Positive Feedback

    A mechanism that amplifies or enhances an initial change in a physiological system, leading to a more rapid and extreme response.

    Homeostasis

    A set of interconnected physiological processes that maintain a stable internal environment within the body, despite external changes.

    Positive Feedback & Blood Clotting

    The process of blood clotting, where the initial formation of a clot triggers the release of clotting factors, ultimately leading to a stable clot.

    Positive Feedback & Labor

    The process of childbirth, where the baby's head pushing against the cervix stimulates the release of oxytocin, further intensifying contractions.

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    Positive Feedback & Breastfeeding

    The release of breast milk is stimulated by the baby sucking, which in turn triggers the release of more milk.

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    Thyroid gland

    A butterfly-shaped gland located in the anterior neck, responsible for producing thyroid hormones (T3 and T4) that regulate metabolism.

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    Thyroid follicles

    The functional units of the thyroid gland, composed of follicular cells surrounding a colloid substance containing thyroglobulin, iodine, and thyroid hormones.

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    Follicular cells

    Specialized cells within the thyroid follicles that produce thyroid hormones (T3 and T4) through a complex chemical pathway.

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    Thyroglobulin

    A thick colloid substance within thyroid follicles containing thyroglobulin, iodine, and thyroid hormones.

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    T3 and T4 (Triiodothyronine and Thyroxine)

    Thyroid hormone secreted by the follicular cells, responsible for regulating cellular metabolism and influencing energy production.

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    Extrafollicular cells

    Cells located around the thyroid follicles that secrete calcitonin, a hormone essential for regulating blood calcium levels.

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    TSH (Thyroid Stimulating Hormone)

    A hormone produced by the anterior pituitary gland that stimulates the thyroid gland to produce and release thyroid hormones.

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    Thyroid-binding Globulins (TBGs)

    Proteins in the bloodstream responsible for binding and transporting thyroid hormones, ensuring their availability to tissues as needed.

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    Somatotropin (GH)

    A hormone produced by the anterior pituitary that stimulates cell growth and replication. It has both direct effects (on fat and liver) and indirect effects (through IGFs).

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    IGFs (Insulin-like Growth Factors)

    Insulin-like growth factors produced by the liver in response to growth hormone (GH). They promote cell growth and metabolism.

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    Follitropin (FSH)

    A hormone secreted by the anterior pituitary that promotes the production and maturation of sperm in males.

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    Lutropin (LH)

    A hormone secreted by the anterior pituitary that stimulates ovulation and hormone production in females, and androgen production in males.

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    Mammotropin (PRL)

    A hormone released from the anterior pituitary that stimulates milk production in females and enhances testosterone sensitivity in males.

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    Pars Intermedia

    The part of the anterior pituitary that secretes melanocyte-stimulating hormone (MSH). It's not functionally active in adults.

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    Posterior Pituitary

    The posterior pituitary, also known as the neurohypophysis, stores and releases hormones like ADH and oxytocin.

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    Antidiuretic Hormone (ADH)

    A hormone secreted by the posterior pituitary that regulates water reabsorption in the kidneys, leading to decreased urine output.

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    Oxytocin (OT)

    A hormone secreted by the posterior pituitary that stimulates uterine contractions during labor and milk ejection after childbirth.

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    Hypothalamic-Pituitary Axis

    Hormones produced by the hypothalamus and stored/released by the pituitary glands.

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    What is homeostasis?

    A state of balance in the body, especially the maintenance of a constant internal environment.

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    What is calcitonin?

    A hormone produced by the C cells of the thyroid gland that lowers blood calcium levels by inhibiting osteoclast activity, promoting calcium excretion by the kidneys, and reducing calcium absorption in the small intestine.

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    What are C cells?

    Cells located in the thyroid gland that are responsible for producing and releasing calcitonin.

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    What is osteolysis?

    The process by which bone cells break down bone tissue, releasing calcium into the bloodstream.

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    What are chief cells?

    Cells in the parathyroid glands that produce parathyroid hormone (PTH).

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    What is parathyroid hormone (PTH)?

    A hormone produced by the parathyroid glands that increases blood calcium levels by stimulating osteoclast activity, promoting calcium reabsorption by the kidneys, and promoting the formation of calcitriol.

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    What is calcitriol?

    A hormone produced by the kidneys that enhances the actions of PTH, increasing the absorption of calcium and phosphate in the digestive tract.

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    What is the adrenal cortex?

    The outer layer of the adrenal gland that produces corticosteroids.

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    What are corticosteroids?

    Hormones produced by the adrenal cortex that play a vital role in maintaining life, including regulating metabolism, stress response, and electrolyte balance.

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    What are transcortins?

    A group of proteins that bind to corticosteroids in the bloodstream, allowing their transport throughout the body.

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    Islets of Langerhans

    The endocrine tissue within the pancreas consisting of clusters of hormone-secreting cells.

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    Hyperglycemia

    A condition characterized by abnormally high blood glucose levels.

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    HbA1C

    A test that measures the average blood glucose level over the lifespan of red blood cells (approximately 3 months).

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    Diabetes mellitus

    A metabolic disorder characterized by high blood glucose levels that overwhelm the reabsorption capabilities of the kidneys, leading to glucose in the urine.

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    Type 1 diabetes

    A type of diabetes characterized by inadequate insulin production by the pancreas.

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    Type 2 diabetes

    The most common type of diabetes, characterized by insulin resistance, where the body doesn't respond properly to insulin.

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    Gluconeogenesis

    The process of generating new glucose from non-carbohydrate sources, such as amino acids and glycerol.

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    Thymosins

    Hormones produced by the thymus gland that promote the development of T lymphocytes.

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    Pinealocytes

    Specialized cells in the pineal gland that produce melatonin.

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    Melatonin

    A hormone produced by the pineal gland that regulates sleep-wake cycles, inhibits reproductive function, and acts as an antioxidant.

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    Parathyroid Hormone (PTH)

    A hormone released by the kidneys in response to low blood calcium levels, stimulating the production of calcitriol (vitamin D3 active form) to increase calcium absorption from the gut.

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    Calcitriol

    The active form of vitamin D3, produced by the kidneys, that promotes calcium absorption in the intestines, bone formation, and calcium reabsorption in the kidneys.

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    Atrial Natriuretic Peptide (ANP)

    A hormone produced by heart muscle cells in response to increased blood volume and pressure. It inhibits the release of renin, aldosterone, and ADH, leading to decreased blood pressure and volume.

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    Ghrelin

    A hormone released from the stomach in response to an empty stomach. It stimulates appetite.

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    Leptin

    A hormone produced by adipose tissue that plays a role in regulating appetite and energy expenditure. It signals satiety.

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    Negative Feedback

    A mechanism that counteracts or reduces an initial change in a physiological system, returning it to a stable set point.

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    Study Notes

    The Endocrine System

    • Homeostasis is a state of chemical and thermal balance, maintaining a stable internal environment.
    • Nervous and endocrine systems maintain homeostasis.
    • Endocrine system is responsible for long-term processes like growth, development, and reproduction.
    • Nervous system manages rapid communication and split-second responses.
    • The neuroendocrine response is a combined action of both systems maintaining homeostasis.
    • Endocrine system communicates through hormones released directly into the bloodstream and ECF (extracellular fluid).
    • Target cells have specific receptors to bind and interpret hormones.
    • Hormones change the type, amount, and activity of enzymes and proteins, influencing responses to internal and external changes in the environment.

    Classes of Hormones

    • Amino acid derivatives are derived from tyrosine and tryptophan, including thyroid hormone and catecholamines (epinephrine, norepinephrine, and dopamine). Melatonin is a primary tryptophan derivative.
    • Peptide hormones are chains of amino acids, often activated before or after secretion. Glycoproteins have carbohydrate chains, while other small polypeptides and proteins are shorter chains.
    • Lipid derivatives include eicosanoids (leukotrienes, prostaglandins, thromboxanes, and prostacyclins) as well as steroid hormones (structurally similar to cholesterol). Steroids are typically bound to transport proteins in the blood.

    Mechanisms of Hormone Action

    • Hormones interact with specific receptors on target cells.
    • The number and type of receptors determine a cell's sensitivity to a hormone.
    • Lipid-soluble hormones (steroids and eicosanoids) cross the plasma membrane to bind intracellular receptors, affecting gene expression directly.
    • Water-soluble hormones (catecholamines and peptides) bind to receptors on the cell surface, activating second messenger systems.
    • Second messenger systems, like cyclic AMP or calcium ions, amplify the signal and create effects within the cell.

    Indirect Effects of Hormones

    • Hormone-receptor binding on the cell surface activates a G protein, which can activate other enzymes like adenylate cyclase.
    • Adenylate cyclase converts ATP to cyclic AMP (cAMP), a second messenger.
    • cAMP activates protein kinases that phosphorylate other proteins, leading to cellular responses.
    • Hormone binding to a different receptor type activates the enzyme phospholipase C (PLC), ultimately increasing calcium levels in the cell.
    • Calcium acts as another second messenger, activating enzymes and altering cellular functions.

    Direct Effects of Hormones (Steroids)

    • Steroid hormones diffuse through the cell membrane.
    • Hormones bind to receptors in the cytoplasm or nucleus of the target cell.
    • Hormone-receptor complexes bind to DNA, activating or deactivating specific genes, changing transcription and protein synthesis.
    • This affects the target cell's metabolic activity and structure.

    Direct Effects of Hormones (TH) - Thyroid Hormones

    • Thyroid hormones cross the plasma membrane and bind to receptors in the nucleus.
    • Hormone-receptor complexes activate certain genes, influencing the rate of transcription.
    • Metabolic activity is altered through changes in enzyme concentrations within cells, particularly in mitochondria that increase ATP production.

    Modulation of Target Cell Sensitivity

    • Cells can adjust sensitivity to hormones by changing receptor numbers.
    • Up-regulation increases receptor numbers, making the cell more sensitive to a hormone.
    • Down-regulation decreases receptor numbers, making the cell less sensitive to a hormone.
    • Factors like high hormone concentrations and/or diseases lead to down-regulation or up-regulation.

    Control of Hormones Negative Feedback

    • Negative feedback: homeostasis is maintained through the regulation of hormone amounts in response to fluctuations.
    • Endocrine glands adjust hormone production in response to changes in their concentrations.
    • Declining hormone levels trigger increased hormone production; rising levels trigger inhibition of hormone production.

    Negative Feedback Loop Example

    • Hypothalamus releases TRH.
    • Anterior pituitary releases TSH.
    • Thyroid releases T3 and T4.
    • Rising T3 and T4 levels inhibit the release of TRH and TSH.
    • Maintaining a stable output of hormones.

    Positive Feedback Loop Examples

    • Childbirth – uterine contractions. Positive feedback reinforces the stimulus.
    • Blood clotting – platelets aggregate to stop bleeding. Positive feedback accelerates the process until homeostasis is reached

    The Pituitary Gland

    • AKA the master gland, it controls/influences many other glands.
    • Three main parts: anterior lobe, posterior lobe, and intermediate.
    • Anterior lobe (adenohypophysis) - makes and releases its hormones (tropic hormones).
    • Posterior lobe (neurohypophysis) - stores and releases hypothalamic hormones (ADH & OT).
    • Intermediate lobe (pars intermedia) - produces melanocyte-stimulating hormone (MSH).

    Anterior Pituitary

    • Composed of 5 cell types: -Thyrotropes (TSH) – thyroid stimulating hormone
    • Corticotropes (ACTH) – adrenal cortex stimulating hormone. -Gonadotropes (FSH & LH) – follicle-stimulating hormone and luteinizing hormone.
    • Somatotropes (GH)- growth hormone.
    • Mamotropes (PRL) – prolactin

    Posterior Pituitary

    • Stores and releases Antidiuretic hormone (ADH) and Oxytocin (OT).
    • No hormones are synthesised in the posterior lobe.

    Hormones of the Adrenal Glands

    • Adrenal cortex (3 zones): zona glomerulosa, zona fasciculata, zona reticularis
    • Mineralocorticoids (zona glomerulosa) – regulation of mineral balance, especially sodium (aldosterone).
    • Glucocorticoids (zona fasciculata) – carbohydrate and protein metabolism, stress response (cortisol).
    • Gonadocorticoids (zona reticularis) – small amounts; conversion to sex hormones

    Adrenal Medulla

    • Produces epinephrine and norepinephrine (fight-or-flight response).
    • Sympathetic Nervous System stimulation leads to increased release of these hormones.
    • Increased blood glucose, fatty acid mobilization, increased cardiac rate, and elevated blood pressure.

    Pancreas

    • Both exocrine and endocrine functions
    • Exocrine function: 99% of acini—produce alkaline pancreatic juice with digestive enzymes
    • Endocrine function: islets of Langerhans (~2 million cells).
    • Alpha cells: produce glucagon
    • Beta cells: produce insulin
    • Delta cells: produce somatostatin
    • F Cells: produce pancreatic polypeptide

    Diabetes

    • Type 1 diabetes: characterized by inadequate insulin production by pancreatic beta cells.
    • Type 2 diabetes: tissues don't respond properly to insulin.
    • Both types lead to elevated blood glucose levels.

    Secondary Endocrine Functions

    • Intestines: hormones for digestive control.
    • Kidneys: erythropoietin (EPO), calcitriol, renin.
    • Heart: atrial natriuretic peptides (ANP) and brain natriuretic peptide (BNP).
    • Thymus: thymosins (T lymphocyte development).
    • Gonads: hormones for reproduction.

    Hormonal Interactions

    • Antagonistic hormones: have opposing effects (e.g., calcitonin and parathyroid hormone).
    • Synergistic hormones: have additive effects (e.g., glucose sparing of GH and glucocorticoids).
    • Permissive hormones: 1 hormone is needed for another to exert its effect (e.g., TH is needed for full effects of epinephrine).
    • Integrative hormones: different hormones in different tissues work together in combination (e.g., calcitriol and PTH).

    General Adaptation Syndrome (GAS)

    • Three phases of stress response: alarm, resistance, exhaustion.
    • Alarm phase: immediate response involving epinephrine and norepinephrine.
    • Resistance phase: longer-term response with increased glucocorticoid levels.
    • Exhaustion phase: body reserves are depleted, and homeostasis cannot be maintained.

    Additional Topics

    • Pineal gland: produces melatonin involved in circadian rhythms and regulates reproductive function also related to the color of the skin.
    • Kidney Function: Kidney produces renin to help regulate water and electrolyte balance.
    • Hypothalamic-Pituitary Axis: Hypothalamus regulates the anterior pituitary gland.
    • Hypophyseal Portal System: Specialized blood vessels connecting the hypothalamus and anterior pituitary to allow hormones rapid movement with limited dilution.

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    Endocrine System Notes PDF

    Description

    Explore the functions of the endocrine system and its role in maintaining homeostasis. Learn about different classes of hormones and how they interact with target cells. Understand the importance of hormonal balance in growth, development, and reproduction.

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