The Cell Cycle and Cell Types

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Questions and Answers

What characterizes Stage I cancer?

Cancer has metastasized to distant lymph nodes.

Cancer is large and has significant local extent.

Cancer has spread to nearby organs.

Cancer is only in the cells where it first started. (correct)

What does N0 indicate in cancer staging?

There is involvement of regional lymph nodes.

Regional lymph nodes cannot be assessed.

There are no regional lymph node metastases. (correct)

Distant metastasis has been confirmed.

Which statement is true regarding distant metastasis (M)?

M0 indicates the absence of distant metastasis. (correct)

Mx indicates confirmed distant metastasis.

M1 means there is no distant metastasis present.

M1 indicates that the cancer is localized only.

How are cancer cells classified in Grade I?

They resemble normal cells closely. Signup and view all the answers

What type of biopsy removes the entire tumor and surrounding margins?

Excisional biopsy. Signup and view all the answers

Which of the following conditions is most likely to lead to pain associated with cancer?

Compression of nerve endings Signup and view all the answers

What is a potential consequence of hypercalcemia due to tumors?

Release of parathyroid-like hormone Signup and view all the answers

What does the presence of effusion in cancer patients typically indicate?

Obstruction of blood and lymphatic flow Signup and view all the answers

Which type of tumor is most likely to result in disseminated intravascular coagulation (DIC)?

Lung cancer Signup and view all the answers

Which factor can enhance hypercalcemia in cancer patients?

Dehydration Signup and view all the answers

What type of cancer is specifically mentioned as commonly causing hypercalcemia?

Squamous lung cancer Signup and view all the answers

What is a likely cause of edema in cancer patients?

Lymphatic flow obstruction Signup and view all the answers

What common symptom indicates that cancer might be advanced?

Pain from tumor pressure Signup and view all the answers

What is the primary purpose of interphase in the cell cycle?

To accumulate nutrients and duplicate DNA Signup and view all the answers

What phase of the cell cycle do stable cells primarily reside in?

Gap 0/G0 phase Signup and view all the answers

Which of the following cells would be considered labile cells?

GI lining cells Signup and view all the answers

Permanent cells are characterized by which of the following traits?

They cannot reproduce or multiply Signup and view all the answers

What is the role of the G1 checkpoint in the cell cycle?

To check if all components for mitosis are present Signup and view all the answers

During which phase does DNA replication actually take place?

S phase Signup and view all the answers

What distinguishes discontinuous replication from continuous cell division?

Cells divide at a low wear and tear replacement rate Signup and view all the answers

Which type of cell is likely to enter the cell cycle when stimulated?

Stable cells Signup and view all the answers

What is the primary management option for neutropenia in patients undergoing chemotherapy?

GCSF administration Signup and view all the answers

What should be done immediately if a patient is found to have heart muscle damage during chemotherapy?

Stop medication administration Signup and view all the answers

Which of the following is NOT a preparation step prior to chemotherapy?

Conducting a comprehensive health survey Signup and view all the answers

What type of cancer treatment is hormone therapy primarily used for?

Hormone-sensitive cancers Signup and view all the answers

Which of the following is a method of managing hemorrhagic cystitis?

Hydration therapy Signup and view all the answers

Which medication is commonly used to neutralize chemotherapy infiltration?

Sodium bicarbonate Signup and view all the answers

Which statement about hormone therapy is accurate?

It can stop cancer cells from growing. Signup and view all the answers

What complication can arise from kidney issues during chemotherapy?

Renal failure Signup and view all the answers

What is the primary function of hormone therapy in the treatment of prostate cancer?

To shrink tumors and decrease PSA levels Signup and view all the answers

Which of the following is an example of an antiandrogen used in hormone therapy for prostate cancer?

Bicalutamide (Casodex) Signup and view all the answers

Which serious risk is associated with the use of tamoxifen?

Increased risk of blood clots and stroke Signup and view all the answers

What are possible side effects of hormone therapy mentioned?

Nausea and skin rash Signup and view all the answers

Which therapy is mentioned as effective for relieving symptoms of advanced prostate cancer?

Estrogen therapy (DES) Signup and view all the answers

What effect does LHRH agonists have on testicular androgen levels?

They suppress testicular androgen levels Signup and view all the answers

What additional risk does tamoxifen pose for women specifically?

Increased risk of endometrial cancer Signup and view all the answers

Which of the following is NOT a noted side effect of hormone therapy for prostate cancer?

Weight loss Signup and view all the answers

Study Notes

The Cell Cycle

A vital process by which a single-celled fertilized egg develops into a mature organism
The cycle also plays a key role in tissue and organ renewal
The cell cycle consists of two distinct periods: Interphase and Mitosis
Interphase is when the cell grows, accumulates nutrients needed for mitosis and duplicates its DNA
Mitosis is when the cell splits into two distinct cells, called daughter cells
Activation of each phase of the cell cycle is dependent on the completion of the previous phase

Types of Cells

Stable cells: Multiply only when needed, spend most of their time in the Go phase of the cell cycle, and can be stimulated to enter the cell cycle when needed
Examples of stable cells include liver cells, proximal tubules of the kidneys, and endocrine glands
Labile cells: Multiply constantly throughout life
Examples of labile cells include GI lining, bone marrow, and hair
Permanent cells: Incapable of reproduction or multiplication
Examples of permanent cells include brain cells, heart cells, and skeletal muscle cells

Phases of the Cell Cycle

Gap 0/G0: A resting phase where the cell has left the cycle and has stopped dividing
Interphase: Consists of three subphases:
- Gap 1/G1: Cells increase in size, and the G1 checkpoint control mechanism ensures that everything is ready for DNA synthesis
- Synthesis/S: DNA replication occurs
- Gap 2/G2: The cell prepares for mitosis

Cancer

Pain: Can be caused by pressure on nerve endings, distention of organs or vessels, or lack of oxygen to tissues and organs
Effusion: Occurs when lymphatic flow is obstructed, leading to fluid build-up in serous cavities

Cancer Staging

Stage I: Cancer is only in the cells where it first started, and the area is small. Considered early stage and often curable.
Stage II: Cancer is in the organ where it first started, and may be larger than Stage I.
Stage III: Cancer has spread to nearby lymph nodes or tissues.
Stage IV: Cancer has spread to distant parts of the body.

Cancer Grading

Grade I: Cancer cells resemble normal cells.
Grade II: Cancer cells are somewhat abnormal.
Grade III: Cancer cells are very abnormal.
Grade IV: Cancer cells are highly abnormal.

Hormone Therapy

Used to treat cancers that utilize hormones for growth, like prostate and breast cancers
Works by slowing or stopping the growth of cancer cells
Approaches:
- Suppressing the production of hormones
- Blocking the action of hormones
- Removing glands that produce hormones

Side Effects of Hormone Therapy

Fatigue
Skin rash
Loss of appetite or weight gain
Headaches
Vaginal dryness, itching, or irritation of the skin around the vagina
Increased risk of blood clots, stroke, and eye problems
Increased risk of endometrial cancer and uterine sarcoma

Biopsy Types

Excisional: For easily accessible tumors, the entire tumor and surrounding marginal tissues are removed
Incisional: A sample of tissue is removed for examination
Needle: A small sample of tissue is withdrawn using a needle.

Chemotherapy

Pre-medication: Given prior to chemotherapy to help prevent side effects.
Side Effects:
- Cardiac: Heart muscle damage
- Respiratory: Pulmonary fibrosis
- Genitourinary: Hemorrhagic cystitis and loss of libido
- Kidney: Renal failure
Neutropenia (Low White Blood Cell Count):
- Stop medication administration immediately.
- Ice application (except for vinca alkaloids).
- Aspiration of infiltrated medication (by the physician).
- Injection of neutralizing solution (e.g., sodium thiosulfate, sodium bicarbonate).
- Plastic Surgery Consultation

Causes of Cancer

Physical Agents:
- Exposure to radiation
- Exposure to sunlight
Other etiologies (causes):
- Viral infections
- Genetic predisposition
- Environmental factors
- Lifestyle choices

Disseminated Intravascular Coagulation (DIC)

Can occur with all tumors, but is more likely with cancer of the lung, pancreas, stomach, and colon.
Characterized by abnormal blood clotting and bleeding throughout the body.

Edema

Caused by obstructed blood and lymphatic flow
A result of decreased serum protein from anorexia and malnutrition
Can contribute to swelling in various parts of the body.

Hypercalcemia

Occurs due to tumors of the bone, multiple myeloma, squamous lung cancer, and cancer of the breast.
Results from metastasis to the bone and increased bone breakdown.
Production of a parathyroid-like hormone enhances the release of calcium from the bones.

Additional Notes

TNM Staging System: This system uses three main categories to describe the extent of cancer:
- T (Tumor): Describes the size and location of the primary tumor.
- N (Nodes): Describes whether the cancer has spread to nearby lymph nodes.
- M (Metastasis): Describes whether the cancer has spread to distant parts of the body.

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Description

Explore the key phases of the cell cycle, including Interphase and Mitosis, and understand the characteristics of stable, labile, and permanent cells. This quiz will test your knowledge on how these processes contribute to growth and tissue renewal in organisms.