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The Arthus Reaction and Type IV Hypersensitivity Quiz

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Questions and Answers

Which type of adverse drug reaction is characterized by chronic effects after long use of drugs?

Type D
Type C (correct)
Type B
Type A

What is the term used to describe unavoidable undesirable normal actions produced by therapeutic dose of a drug?

Secondary Effect
Super-sensitivity
Over-dose
Side Effect (correct)

Which type of adverse drug reaction is characterized by an abnormal unpredictable reaction usually due to an antigen/antibody reaction?

Type II
Type III
Type I (correct)
Type IV

Which of the following is NOT a pattern of adverse drug reactions (ADR) according to the ABCDE Classification?

Bizzar (A) Signup and view all the answers

What is the difference between tolerance and desensitization (Tachyphylaxis)?

Tolerance is the complete loss of response to a drug, while desensitization is the decreased response to a drug over time (C) Signup and view all the answers

What is the clinical principle regarding drug effects?

Drugs should have minimum side effects (D) Signup and view all the answers

Which type of hypersensitivity reaction is characterized by the involvement of T-lymphocytes and inflammation?

Type IV (A) Signup and view all the answers

What is the main difference between allergy and idiosyncrasy?

Allergy is an abnormal response due to genetic abnormality, while idiosyncrasy is an unpredictable abnormal response due to genetic abnormality. (C) Signup and view all the answers

What are the characteristics of acquired tolerance?

Reversal of drug effects with time, varies from one drug to another, does not affect all actions to the same extent (A) Signup and view all the answers

Which of the following best describes primary failure in the treatment of Type I diabetes mellitus?

Failure of insulin treatment due to occurrence of tolerance (D) Signup and view all the answers

What is the term used to describe a more gradual loss of response to a drug that occurs over days or weeks due to repeated administration?

Pharmacodynamic tolerance (C) Signup and view all the answers

What is the term used to describe a sudden loss of response to a drug?

Tachyphylaxis (D) Signup and view all the answers

Which of the following is NOT a mechanism of tachyphylaxis?

Increased metabolic degradation (D) Signup and view all the answers

What does desensitization refer to?

Signal attenuation in response to continuous stimulation of cells by receptor agonists (D) Signup and view all the answers

What is secondary failure in the treatment of Type I diabetes mellitus?

Failure of insulin treatment due to a more rapid loss of response (B) Signup and view all the answers

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