Podcast
Questions and Answers
What is the term used to describe the process of generating antibody diversity during the development of B lymphocytes into naïve B cells?
What is the term used to describe the process of generating antibody diversity during the development of B lymphocytes into naïve B cells?
- Somatic hypermutation (correct)
- Affinity maturation
- Selection
- Maturation
What is the term used to describe the switching of heavy chain isotypes (classes) during antibody production?
What is the term used to describe the switching of heavy chain isotypes (classes) during antibody production?
- Antigen recognition
- Antibody responses
- Affinity maturation
- Isotype switching (correct)
Which term refers to the specific part of an antigen that is recognized by an antibody?
Which term refers to the specific part of an antigen that is recognized by an antibody?
- Epitope (correct)
- Determinant
- Avidity
- Affinity
Which type of antigen does not require the help of T cells for an immune response?
Which type of antigen does not require the help of T cells for an immune response?
What is the term used to describe the overall strength of binding between an antibody and an antigen?
What is the term used to describe the overall strength of binding between an antibody and an antigen?
Which term refers to a small molecule that can bind to an antibody but cannot elicit an immune response on its own?
Which term refers to a small molecule that can bind to an antibody but cannot elicit an immune response on its own?
Which of the following is a major form of humoral immunity?
Which of the following is a major form of humoral immunity?
What is an immunogen?
What is an immunogen?
What is an epitope?
What is an epitope?
Which of the following is true about antigens?
Which of the following is true about antigens?
What is the general order of immunogenicity?
What is the general order of immunogenicity?
What is the combination of affinity and valency called?
What is the combination of affinity and valency called?
Which type of antigen requires T cell help for B cell activation?
Which type of antigen requires T cell help for B cell activation?
What happens when a T-dependent antigen binds to a B cell?
What happens when a T-dependent antigen binds to a B cell?
Which type of antigen activates B cells directly through receptor crosslinking?
Which type of antigen activates B cells directly through receptor crosslinking?
Which type of T-independent antigen crosslinks both the B cell receptor (BCR) and another receptor(s)?
Which type of T-independent antigen crosslinks both the B cell receptor (BCR) and another receptor(s)?
Where do T-independent 2 (TI-2) antigens often occur?
Where do T-independent 2 (TI-2) antigens often occur?
Which cells secrete cytokines that can induce isotype switching and plasma cell differentiation in response to TI-2 antigens?
Which cells secrete cytokines that can induce isotype switching and plasma cell differentiation in response to TI-2 antigens?
What are the structural elements in monomeric forms of antibody isotypes?
What are the structural elements in monomeric forms of antibody isotypes?
Which antibody isotype forms pentamers?
Which antibody isotype forms pentamers?
What is the purpose of somatic hypermutation in B cell responses?
What is the purpose of somatic hypermutation in B cell responses?
Which type of antigen generally does not undergo isotype switching or affinity maturation?
Which type of antigen generally does not undergo isotype switching or affinity maturation?
Which type of antigen binds and crosslinks multiple BCR or innate receptors?
Which type of antigen binds and crosslinks multiple BCR or innate receptors?
Which type of antigen binds BCR and is endocytosed and processed for loading to MHC-II?
Which type of antigen binds BCR and is endocytosed and processed for loading to MHC-II?
What is the purpose of CD4 Th cell help in T-dependent antigen response?
What is the purpose of CD4 Th cell help in T-dependent antigen response?
Which type of antigen generally does NOT undergo isotype switching or affinity maturation?
Which type of antigen generally does NOT undergo isotype switching or affinity maturation?
What is the purpose of CD4 Th cell help in a T-dependent antigen response?
What is the purpose of CD4 Th cell help in a T-dependent antigen response?
Where do T-independent 2 (TI-2) antigens often occur?
Where do T-independent 2 (TI-2) antigens often occur?
What is the term used to describe the overall strength of binding between an antibody and an antigen?
What is the term used to describe the overall strength of binding between an antibody and an antigen?
Which type of antigen binds and crosslinks multiple BCR or innate receptors?
Which type of antigen binds and crosslinks multiple BCR or innate receptors?
What is an epitope?
What is an epitope?
Which antibody isotype forms pentamers?
Which antibody isotype forms pentamers?
What is the purpose of somatic hypermutation in B cell responses?
What is the purpose of somatic hypermutation in B cell responses?
Which of the following is true about antibody isotypes?
Which of the following is true about antibody isotypes?
Which structural elements are present in monomeric forms of antibody isotypes?
Which structural elements are present in monomeric forms of antibody isotypes?
Which antibody isotype forms pentamers?
Which antibody isotype forms pentamers?
What is the purpose of somatic hypermutation in B cell responses?
What is the purpose of somatic hypermutation in B cell responses?
What is the term used to describe the process of generating antibody diversity during the development of B lymphocytes into naïve B cells?
What is the term used to describe the process of generating antibody diversity during the development of B lymphocytes into naïve B cells?
What are the major steps in B cell development?
What are the major steps in B cell development?
What is the purpose of CD4 Th cell help in T-dependent antigen response?
What is the purpose of CD4 Th cell help in T-dependent antigen response?
What happens when a T-dependent antigen binds to a B cell?
What happens when a T-dependent antigen binds to a B cell?
Which type of antigen requires T cell help for B cell activation?
Which type of antigen requires T cell help for B cell activation?
Which region of the immunoglobin (Ig) domain is responsible for binding antigens?
Which region of the immunoglobin (Ig) domain is responsible for binding antigens?
What is the function of the Fc region of the immunoglobin (Ig) domain?
What is the function of the Fc region of the immunoglobin (Ig) domain?
What is the term used to describe the ability of an antibody to bind different but structurally similar antigens?
What is the term used to describe the ability of an antibody to bind different but structurally similar antigens?
What is the term used to describe the process of generating antibody diversity during the development of B lymphocytes into naïve B cells?
What is the term used to describe the process of generating antibody diversity during the development of B lymphocytes into naïve B cells?
Which region of the immunoglobin (Ig) domain is responsible for structural flexibility?
Which region of the immunoglobin (Ig) domain is responsible for structural flexibility?
Which accessory molecules allow the B cell receptor (BCR) to transmit the antigen binding signal for B cell activation?
Which accessory molecules allow the B cell receptor (BCR) to transmit the antigen binding signal for B cell activation?
What is the term used to describe the process of increasing the affinity of antibodies through spontaneous mutations?
What is the term used to describe the process of increasing the affinity of antibodies through spontaneous mutations?
Which type of antigen requires the help of T cells for an immune response?
Which type of antigen requires the help of T cells for an immune response?
Which antibody isotype has the highest valency?
Which antibody isotype has the highest valency?
Which of the following is true about haptens?
Which of the following is true about haptens?
Which of the following is true about antigen valency?
Which of the following is true about antigen valency?
What is the primary target of humoral immunity?
What is the primary target of humoral immunity?
What is the term used to describe the smaller portion of an antigen specifically bound by a T cell or antibody?
What is the term used to describe the smaller portion of an antigen specifically bound by a T cell or antibody?
What is the general order of immunogenicity?
What is the general order of immunogenicity?
What is the term used to describe the total binding strength between all antigen-epitope pairs in multivalent antigen-antibody interactions?
What is the term used to describe the total binding strength between all antigen-epitope pairs in multivalent antigen-antibody interactions?
What is the structure of antibodies?
What is the structure of antibodies?
What is the purpose of somatic hypermutation in B cell responses?
What is the purpose of somatic hypermutation in B cell responses?
What is the purpose of CD4 Th cell help in a T-dependent antigen response?
What is the purpose of CD4 Th cell help in a T-dependent antigen response?
What is the term used to describe the switching of heavy chain isotypes (classes) during antibody production?
What is the term used to describe the switching of heavy chain isotypes (classes) during antibody production?
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