7 Questions
What is the name of the mushroom that contains a toxin that inhibits mRNA synthesis?
Amanita Phalloides
What is the name of the toxin found in Amanita Phalloides that inhibits RNA Pol II?
a-amanitin
What does a-amanitin do once it binds to RNA Pol II?
Inactivates it
Is the complex formed between a-amanitin and RNA Pol II reversible?
No, it is irreversible
What are the symptoms caused by ingestion of Amanita Phalloides?
GI disturbances, electrolyte imbalance, fever, liver and kidney dysfunction
What is the mechanism of action of a-amanitin?
Inhibits mRNA synthesis by forming a complex with RNA Pol II
Can ingestion of Amanita Phalloides lead to death?
Yes, in 50-90% of cases within a few days
Test your knowledge on the deadly mushroom toxin, Amanita Phalloides, and its inhibitory effects on RNA Pol II. Learn about the irreversible complex formed between the toxin and RNA Pol II, leading to the inhibition of mRNA synthesis. Explore the symptoms caused by this toxin, including gastrointestinal disturbances and electrolyte imbalances. Take the quiz now and become an expert on inhibitors of RNA Pol II.
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