7 Questions
What is the most common cause of meningitis in neonates?
GBS
What is the most common organism to cause bacteremia in neonates?
E) coli
Which type of infections are now rare in the US?
Gram-negative infections
Which inflammatory markers are now available for point-of-care testing and are more accurate for risk stratification?
CRP and procalcitonin
What is the implication of the shift from Gram-positive to Gram-negative predominance for testing and selection of antimicrobial drugs?
Gram-negative antibiotics should be used more frequently
What is the approximate time it takes for multiplex PCR testing of positive blood cultures to identify bacterial pathogens and antimicrobial resistance genes?
<1 hour
What has led to identifying emerging viral agents?
Multiplex respiratory viral testing
Study Notes
- Bacterial infections in neonates and infants have changed since the 1980s due to various factors
- E. coli is now the most common organism to cause bacteremia in neonates
- GBS remains the most common cause of meningitis in neonates
- L. monocytogenes infections are now rare in the US
- The shift from Gram-positive to Gram-negative predominance has implications for testing and selection of antimicrobial drugs
- CRP and procalcitonin are now available for point-of-care testing and are more accurate inflammatory markers for risk stratification
- Automated blood culture systems can now identify most bacterial pathogens in <24 hours
- Multiplex PCR testing of positive blood cultures can identify bacterial pathogens and antimicrobial resistance genes in approximately 1 hour
- Rapid viral PCR and multiplex respiratory viral testing have led to identifying emerging agents
- Genomic diagnostics for IBIs is still in its relative infancy, including both genomic identification of viral and bacterial genetic material as well as identifying host genomic responses to viral or bacterial infections.
Test your knowledge about bacterial and viral infections in neonates and infants with this informative quiz! Learn about the changing trends in bacterial infections, the most common organisms causing bacteremia and meningitis, and advancements in testing and identifying pathogens. Discover the benefits of point-of-care testing and rapid PCR testing, as well as the implications for selecting antimicrobial drugs. This quiz will also touch on the emerging field of genomic diagnostics and its potential to revolutionize the way we diagnose and treat infections.
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