Test your knowledge on herpesviruses, varicella-zoster, and Epstein-Barr virus w...
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Questions and Answers

Which type of herpesviruses establish latent infection in lymphocytes?

  • Alpha herpesviruses
  • Gamma herpesviruses
  • All of the above (correct)
  • Beta herpesviruses

    • Which type of herpesvirus is associated with neonatal herpes infection?

  • Gamma herpesvirus
  • None of the above
  • Beta herpesvirus
  • Alpha herpesvirus (correct)

    • Which herpesvirus is associated with acute gingivostomatitis, cold sores, keratoconjunctivitis, and encephalitis?

  • VZV
  • CMV
  • HSV-1 (correct)
  • HSV-2

    • Which herpesvirus is associated with neonatal herpes infection?

    <p>HSV-2</p> Signup and view all the answers

    Which herpesvirus is the most common cause of infectious mononucleosis?

    <p>EBV</p> Signup and view all the answers

    Which virus is associated with chickenpox?

    <p>Varicella-zoster virus</p> Signup and view all the answers

    Which herpesvirus is primarily transmitted through saliva and sexual contact?

    <p>HSV-2</p> Signup and view all the answers

    Which of the following herpesviruses is NOT included in the human herpesvirus classification?

    <p>HPV</p> Signup and view all the answers

    What is the commonest childhood tumor in parts of Africa?

    <p>Burkitt's lymphoma</p> Signup and view all the answers

    Which herpesvirus is the most common cause of infectious mononucleosis?

    <p>EBV</p> Signup and view all the answers

    What is the commonest childhood tumor in parts of Africa?

    <p>Burkitt's lymphoma</p> Signup and view all the answers

    Which of the following is NOT a condition caused by HSV-1?

    <p>Genital herpes</p> Signup and view all the answers

    Which herpesvirus is associated with Kaposi's sarcoma?

    <p>Beta herpesvirus</p> Signup and view all the answers

    Which herpesvirus is associated with Kaposi's sarcoma and other malignancies?

    <p>HHV-8</p> Signup and view all the answers

    What is the drug of choice for most situations for antiviral chemotherapy for HSV?

    <p>Acyclovir</p> Signup and view all the answers

    Which herpesvirus is associated with Burkitt's lymphoma, the commonest childhood tumor in parts of Africa?

    <p>EBV</p> Signup and view all the answers

    Which of the following is NOT associated with EBV?

    <p>Kaposi's sarcoma</p> Signup and view all the answers

    What is the drug of choice for most situations of herpesvirus infection?

    <p>Acyclovir</p> Signup and view all the answers

    Which herpesvirus is associated with shingles, a reactivation of a primary infection resulting in chickenpox?

    <p>VZV</p> Signup and view all the answers

    What is the drug of choice for most situations of herpesvirus infections?

    <p>Acyclovir</p> Signup and view all the answers

    Which virus is the most common cause of infectious mononucleosis?

    <p>Epstein-Barr virus</p> Signup and view all the answers

    Which herpesvirus is primarily transmitted through saliva and sexual contact?

    <p>HSV-1</p> Signup and view all the answers

    What is the commonest childhood tumor in parts of Africa associated with HHV-4?

    <p>Burkitt's lymphoma</p> Signup and view all the answers

    Which herpesvirus is associated with Kaposi's sarcoma and other malignancies?

    <p>HHV-8</p> Signup and view all the answers

    Which herpesvirus is associated with a poor prognosis due to late presentation?

    <p>EBV</p> Signup and view all the answers

    Which of the following is NOT associated with CMV?

    <p>Neonatal herpes infection</p> Signup and view all the answers

    Which herpesvirus is associated with latent infection in lymphocytes?

    <p>Beta herpesvirus</p> Signup and view all the answers

    Which herpesvirus is associated with neonatal herpes infection, which can lead to death and intellectual disability?

    <p>HSV-2</p> Signup and view all the answers

    What is the fatal condition associated with EBV that is X-linked?

    <p>X-linked lymphoproliferative syndrome</p> Signup and view all the answers

    Which herpesvirus is associated with nasopharyngeal carcinoma, which is prevalent in S. China?

    <p>EBV</p> Signup and view all the answers

    Which herpesvirus can reactivate in immunocompromised patients, leading to lymphoproliferative lesions and lymphoma in unusual sites?

    <p>EBV</p> Signup and view all the answers

    Which virus can reactivate in immunocompromised patients, leading to lymphoproliferative lesions and lymphoma in unusual sites?

    <p>Epstein-Barr virus</p> Signup and view all the answers

    Which of the following is NOT a method for diagnosing EBV?

    <p>Culture</p> Signup and view all the answers

    Which herpesvirus is associated with oral hairy leukoplakia?

    <p>EBV</p> Signup and view all the answers

    What is the most prevalent subtype of herpesvirus associated with nasopharyngeal carcinoma?

    <p>None of the above</p> Signup and view all the answers

    Which herpesvirus is associated with X-linked lymphoproliferative syndrome, a fatal condition?

    <p>EBV</p> Signup and view all the answers

    Which virus is triggered by EBV and occurs in patients with weak immune systems?

    <p>Epstein-Barr virus</p> Signup and view all the answers

    Which herpesvirus is associated with Kaposi's sarcoma and other malignancies?

    <p>HHV-8</p> Signup and view all the answers

    Which herpesvirus has low seroprevalence in the general population?

    <p>HHV-8</p> Signup and view all the answers

    Which herpesvirus has low seroprevalence in the general population?

    <p>HHV-8</p> Signup and view all the answers

    Study Notes

    1. Herpesviridae are large double-stranded DNA viruses that replicate in the nucleus of the host cell.
    2. There are alpha, beta, and gamma herpesviruses that establish latent infection in lymphocytes.
    3. Human herpesvirus classification includes HSV-1, HSV-2, VZV, EBV, CMV, and KSHV.
    4. HSV-1 and HSV-2 share several cross-reactive epitopes with each other and antigenic cross-reaction with VZV.
    5. HSV is primarily transmitted through saliva and sexual contact.
    6. HSV-1 causes acute gingivostomatitis, cold sores, keratoconjunctivitis, and encephalitis.
    7. HSV-2 causes genital herpes and neonatal herpes infection.
    8. Neonatal herpes infection can lead to death and intellectual disability.
    9. Diagnosis can be made through culture, detection of antigen, viral DNA, or cytology.
    10. Antiviral chemotherapy with acyclovir is the drug of choice for most situations.
    11. Varicella is a primary infection resulting in chickenpox.
    12. Shingles is a reactivation of varicella-zoster.
    13. Cytomegalovirus is a double-stranded DNA enveloped virus.
    14. Most CMV infections are asymptomatic.
    15. EBV is the most common cause of infectious mononucleosis.
    16. Burkitt's lymphoma is the commonest childhood tumor in parts of Africa.
    17. Hodgkin's lymphoma is often diagnosed in people between 15 and 30 years old.
    18. Nasopharyngeal carcinoma is prevalent in S. China.
    19. HHV-6 and HHV-7 are closely related subtypes of herpesviruses.
    20. Treatment for these viruses includes antiviral medications and hyperimmune globulin.
    • NPC is associated with the V genome and EBV EBNA-1 antigen, and patients have high titers of antibodies against various EBV antigens.
    • NPC prognosis is poor due to late presentation.
    • Environmental and genetic factors may also contribute to NPC.
    • EBV can reactivate in immunocompromised patients, leading to lymphoproliferative lesions and lymphoma in unusual sites.
    • X-linked lymphoproliferative syndrome is a fatal condition associated with EBV.
    • Oral hairy leukoplakia is triggered by EBV and occurs in patients with weak immune systems.
    • Diagnosis of EBV can be done through detection of atypical lymphocytes or serology.
    • There is no effective treatment or vaccine for EBV.
    • HHV-8 is associated with Kaposi's sarcoma and other malignancies.
    • HHV-8 has low seroprevalence in the general population.

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    Description

    Test your knowledge on herpesviruses, varicella-zoster, and Epstein-Barr virus with this informative quiz! From the different types of herpesviruses and their symptoms to the diagnosis and treatment options, this quiz covers it all. You'll also learn about the primary infection resulting in chickenpox, the reactivation of varicella-zoster leading to shingles, and the common causes and symptoms of infectious mononucleosis. So, put your knowledge to the test and see how

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