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Questions and Answers
Which mechanism is responsible for the favorable effect of a gluten-free diet on thyroid autoimmunity?
Which mechanism is responsible for the favorable effect of a gluten-free diet on thyroid autoimmunity?
- Increased levels of TgAb
- Decreased levels of 25-hydroxyvitamin D
- Improvement in vitamin C status
- Improvement in vitamin D status (correct)
Which antibody is more sensitive in the diagnosis of autoimmune thyroid disease?
Which antibody is more sensitive in the diagnosis of autoimmune thyroid disease?
- TgAb
- TPOAb (correct)
- TSH receptor Ab
- Thyroglobulin
Which of the following reduces thyroid antibody titers in women with thyroid autoimmunity?
Which of the following reduces thyroid antibody titers in women with thyroid autoimmunity?
- Gluten-free diet
- Exogenous vitamin C
- Exogenous vitamin D (correct)
- Selenium-rich diet
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Study Notes
- Gluten-free diet has a favorable effect on thyroid autoimmunity.
- Improvement in vitamin D status is one of the mechanisms responsible for this effect.
- Patients on a gluten-free diet had low levels of 25-hydroxyvitamin D.
- Gluten-free diet increased levels of 25-hydroxyvitamin D and correlated with changes in TPOAb titers.
- Exogenous vitamin D reduced thyroid antibody titers in women with thyroid autoimmunity.
- TPOAb are more sensitive than TgAb in the diagnosis of autoimmune thyroid disease.
- Correlations between TPOAb titers and 25-hydroxyvitamin D levels were moderate.
- Other mechanisms may contribute to the favorable effect of the gluten-free diet.
- Improvement in selenium status may be one of these mechanisms.
- Preparations of selenium were found to reduce thyroid autoimmunity by inhibiting a secretory function of human T cells.
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