10 Questions
Which of the following is an example of an antacid that increases pH by absorbing protons?
Sodium bicarbonate
Which of the following drugs blocks H2 receptors to decrease HCl production?
Cimetidine
What is the MOA of proton pump inhibitors (PPIs)?
Irreversibly inhibiting the proton pump
Why are PPIs formulated as coated capsules?
To reach the gastric mucosa
What is the downside of PPIs' effectiveness?
They increase the risk of infection
What are the natural protection mechanisms of the gastroduodenal mucosa?
Tight junctions, mucus, bicarbonate secretion, tissue repair mechanisms, and mucosal prostaglandins
Which of the following is a commonly used mucosal protective agent that enhances natural mucosal defense mechanisms?
Bismuth subsalicylate
What is the MOA of bismuth subsalicylate?
Coating ulcers and erosions, inhibiting chloride secretion, and having anti-virulence effects
What are the potential side effects of cimetidine in men and women?
Gynecomastia and impotence in men, and galactorrhea in women
Which of the following drugs inhibits chloride secretion?
Bismuth subsalicylate
Study Notes
- Antacids absorb protons and increase pH, with sodium bicarbonate being one example.
- Histamine H2 receptor antagonists (H2RAs) block H2 receptors to decrease HCl production, with cimetidine being a prototype.
- Proton pump inhibitors (PPIs) irreversibly inhibit the proton pump to reduce HCl production, with omeprazole being an example.
- PPIs are more effective than H2RAs and are formulated as coated capsules to reach the gastric mucosa.
- PPIs increase the risk of infection due to their effectiveness.
- Mucosal protective agents protect the mucosa from gastric acid.
- Natural protection mechanisms of the gastroduodenal mucosa include tight junctions, mucus, bicarbonate secretion, tissue repair mechanisms, and mucosal prostaglandins.
- Bismuth subsalicylate is a commonly used mucosal protective agent that enhances natural mucosal defense mechanisms.
- The MOA of bismuth subsalicylate involves coating ulcers and erosions, inhibiting chloride secretion, and having anti-virulence effects.
- Cimetidine can cause gynecomastia or impotence in men and galactorrhea in women, and should not be used in pregnant and nursing women.
Test your knowledge of gastric acid control and mucosal protection with this informative quiz! From antacids to proton pump inhibitors, mucosal protective agents to natural defense mechanisms, this quiz covers all the important topics related to gastric acid control and mucosal protection. Discover the mechanisms of action of various drugs used for treating acid reflux and ulcers, and learn about the potential side effects associated with them. Put your knowledge to the test and see how well you understand the fascinating world of gastric acid control and muc
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
