Podcast
Questions and Answers
What is the initial dose of dimethyl fumarate for patients with relapsing MS?
What is the initial dose of dimethyl fumarate for patients with relapsing MS?
What are the common side effects of dimethyl fumarate?
What are the common side effects of dimethyl fumarate?
How can the flushing and GI adverse effects of dimethyl fumarate be improved?
How can the flushing and GI adverse effects of dimethyl fumarate be improved?
Study Notes
- Dimethyl fumarate is used for relapsing MS.
- It shifts cytokine secretion patterns towards anti-inflammatory cytokines.
- It is metabolized to monomethyl fumarate and eliminated through respiration.
- Patients start on 120mg orally twice a day, increasing to 240mg twice a day after 7 days.
- Side effects include flushing, hot flushes, and GI adverse effects.
- Flushing and GI adverse effects can be improved by dose reduction or taking with food.
- Low-dose aspirin can also reduce flushing.
- Dimethyl fumarate can cause elevated hepatic transaminases and decreased lymphocyte count.
- Patients should be monitored for FBC, renal function tests, and LFTs.
- Side effects are most common during the first month of treatment.
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Description
Test your knowledge on dimethyl fumarate, a medication commonly used for treating relapsing multiple sclerosis. Learn about its mechanism of action, dosage, side effects, and monitoring requirements. Discover tips for managing common side effects like flushing and GI issues. Take this quiz to enhance your understanding of dimethyl fumarate and its use in MS management.
