Test Your Knowledge on CREB and TORC Coactivators in Gene Expression

• CREB stimulates gene expression via phosphorylation and recruitment of coactivator CBP
• CREB also functions as a constitutive activator in some cell types
• TORCs are a conserved family of coactivators that enhance CRE-dependent transcription
• TORCs interact with the bZIP DNA binding/dimerization domain of CREB
• TORC recruitment does not modulate CREB DNA binding activity
• TORCs enhance the interaction of CREB with TAF(II)130 component of TFIID
• A chromosomal translocation fuses the CREB binding domain of TORC1 to the Notch coactivator MAML2 in certain mucoepidermoid carcinomas
• Expression of the TORC1-MAML2 chimera strongly induces target gene expression via CREB
• The results reveal a mechanism by which CREB stimulates transcription in normal and transformed cells
• The underlying mechanisms of CREB's constitutive activation are not understood.

Test your knowledge on the transcriptional regulation by CREB and its coactivators TORCs in normal and transformed cells. Explore the phosphorylation and recruitment of CBP, the interaction of TORCs with CREB's bZIP domain, and the enhancement of CREB-TAF(II)130 interaction. Learn about the chromosomal translocation that leads to the CREB binding domain fusion with MAML2 in mucoepidermoid carcinomas and its strong induction of target gene expression. Discover the