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Questions and Answers
Which of the following statements about TORC recruitment is FALSE?
Which of the following statements about TORC recruitment is FALSE?
- TORCs are a family of coactivators that enhance CRE-dependent transcription.
- TORC recruitment modulates CREB DNA binding activity. (correct)
- TORCs interact with the bZIP DNA binding/dimerization domain of CREB
- TORCs enhance the interaction of CREB with TAF(II)130 component of TFIID
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Study Notes
- CREB stimulates gene expression via phosphorylation and recruitment of coactivator CBP
- CREB also functions as a constitutive activator in some cell types
- TORCs are a conserved family of coactivators that enhance CRE-dependent transcription
- TORCs interact with the bZIP DNA binding/dimerization domain of CREB
- TORC recruitment does not modulate CREB DNA binding activity
- TORCs enhance the interaction of CREB with TAF(II)130 component of TFIID
- A chromosomal translocation fuses the CREB binding domain of TORC1 to the Notch coactivator MAML2 in certain mucoepidermoid carcinomas
- Expression of the TORC1-MAML2 chimera strongly induces target gene expression via CREB
- The results reveal a mechanism by which CREB stimulates transcription in normal and transformed cells
- The underlying mechanisms of CREB's constitutive activation are not understood.
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