Test Your Knowledge on Classic Oral Antidiabetic Drugs
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Questions and Answers

What is the mechanism of action of sulfonylureas in treating type 2 diabetes mellitus?

  • They block ATP-sensitive K+ channels in β cells of the pancreas (correct)
  • They increase glucose uptake in target tissues
  • They decrease insulin resistance by increasing insulin secretion
  • They reduce hepatic glucose production and increase peripheral insulin sensitivity

    • Which of the following is a common adverse effect of meglitinides?

  • Hypoglycemia (correct)
  • GIT upset
  • Lactic acidosis
  • Hepatotoxicity

    • What is the therapeutic use of metformin?

  • Polycystic ovary syndrome only in combination with other drugs
  • Type 2 diabetes mellitus only in combination with other drugs
  • Type 2 diabetes mellitus either alone or in combination with other drugs (correct)
  • Type 1 diabetes mellitus

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