Podcast
Questions and Answers
What are the three physiologic events required for production and elimination of urine?
What are the three physiologic events required for production and elimination of urine?
- Decreased perfusion of the kidneys, acute tubular necrosis, and obstruction of urinary outflow (correct)
- None of the above
- Glomerulonephritis, acute interstitial nephritis, and others
- Inulin, exogenous radioactive markers, and IV administration
Which of the following can cause intrinsic AKI?
Which of the following can cause intrinsic AKI?
- Decreased perfusion of the kidneys
- Acute tubular necrosis (correct)
- Obstruction of urinary outflow
- None of the above
What is the ideal marker for eGFR?
What is the ideal marker for eGFR?
- A toxic substance that is not freely filtered at the glomerulus
- A nontoxic substance that is not freely filtered at the glomerulus
- A nontoxic substance that is freely filtered at the glomerulus (correct)
- A toxic substance that is freely filtered at the glomerulus
Study Notes
- Production and elimination of urine require three physiologic events
- AKI can be caused by pre-renal, intrinsic, or post-renal factors
- Pre-renal AKI can be caused by decreased perfusion of the kidneys
- Intrinsic AKI can be caused by acute tubular necrosis, glomerulonephritis, acute interstitial nephritis, and others
- Certain drugs can cause acute tubular necrosis
- Post-renal AKI is caused by obstruction of urinary outflow downstream of the kidney
- Laboratory evaluation includes quantifying glomerular filtration rate (GFR)
- Estimated GFR (eGFR) is widely used to determine baseline kidney function and monitor progression of kidney disease
- Ideal marker for eGFR should be a nontoxic substance that is freely filtered at the glomerulus
- Inulin and exogenous radioactive markers are used to assess GFR but are not readily available to clinicians and require IV administration.
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Description
Are you interested in learning more about the physiology of urine production and elimination, as well as the various factors that can lead to acute kidney injury (AKI)? This quiz covers key concepts such as pre-renal, intrinsic, and post-renal causes of AKI, as well as lab evaluations like quantifying glomerular filtration rate (GFR) and using estimated GFR (eGFR) to monitor kidney function. Test your knowledge and learn more about these important topics!
