Test Your Knowledge of Phagocytes and Immune Defense Mechanisms 17.4

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154 Questions

Which type of cells are responsible for seeking, ingesting, and killing pathogens through phagocytosis?

Phagocytes

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

Which type of leukocytes are the first to arrive within hours of a bacterial infection?

Neutrophils

What are the molecular structures that are common to many groups of pathogenic microbes called?

PAMPs

What is the process called when the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Extravasation

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Lysosomal fusion

Which enzymes digest the pathogen in the phagolysosome?

Lysosomal enzymes

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Extravasation

What are the molecular structures on phagocytes that recognize pathogen-associated molecular patterns (PAMPs) called?

PRRs

Which of the following is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue?

Extravasation

Which type of leukocytes may take several days to leave the bloodstream and differentiate into macrophages?

Monocytes

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Transendothelial migration

What is the name of the process by which the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Lysosomal fusion

Which enzymes digest the pathogen in the phagolysosome?

Lysozyme, Phospholipase, and Proteases

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Processing the remains of the degraded pathogen and presenting key antigens on their cellular surface

What is the name of the process by which leukocytes are able to degrade microbes externally by releasing microbicidal defensin proteins into the area around the cell?

Exocytosis

What are the molecular structures on macrophages that recognize pathogen-associated molecular patterns (PAMPs) called?

Pattern recognition receptors (PRRs)

Which type of leukocytes are the first to arrive within hours of a bacterial infection?

Neutrophils

Which of the following is NOT a function of phagocytes?

Producing antibodies

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

Which leukocytes are the first to arrive within hours of a bacterial infection?

Neutrophils

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the process called when the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Extravasation

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagolysosome formation

Which enzymes digest the pathogen in the phagolysosome?

Lysozyme, phospholipase, and proteases

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Phagocytosis

What is the name of the storehouse of microbicidal defensin proteins that some phagocytes contain and can be released into the area around the cell to degrade microbes externally?

Defensosomes

What is the name of the intracellular signal that activates the phagocyte, causing it to transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation signal

Which of the following is a key function of phagocytes?

Seeking, ingesting, and killing pathogens through phagocytosis

What is the process called by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue?

Extravasation

Which type of leukocytes are the last to arrive and differentiate into macrophages?

Monocytes

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which phagocytes transition from a dormant state of readiness to a state of hyperactivity, proliferation, and enhanced intracellular killing?

Activation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules and roll along the blood vessel walls near the infected area?

Diapedesis

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagolysosome formation

Which enzymes digest the pathogen in the phagolysosome?

Lysozyme, phospholipase, and proteases

What is the additional function of macrophages and dendritic cells besides being antigen-presenting cells involved in the specific adaptive immune response?

Further processing the remains of the degraded pathogen and presenting key antigens on their cellular surface

What is the name of the storehouse of microbicidal defensin proteins that some phagocytes contain?

Granules

What is the name of the pattern recognition receptors (PRRs) that phagocytes use to recognize molecular structures that are common to many groups of pathogenic microbes?

Toll-like receptors (TLRs)

Which of the following is a key function of phagocytes?

Seeking, ingesting, and killing pathogens

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

Which type of leukocytes are the last to arrive and differentiate into macrophages?

Monocytes

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which phagocytes transition from a dormant state of readiness to a state of hyperactivity, proliferation, and enhanced intracellular killing?

Activation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Extravasation

What is the name of the process by which the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Endocytosis

What is the name of the process by which lysosomal enzymes digest the pathogen in the phagolysosome?

Lysosomal degradation

What are reactive oxygen and nitrogen compounds produced to degrade microbes in the phagolysosome?

Hydrogen peroxide and toxic reactive oxygen species

What do some phagocytes contain an internal storehouse of that can be released into the area around the cell to degrade microbes externally?

Defensin proteins

What is the name of the process by which macrophages and dendritic cells present key antigens on their cellular surface to stimulate some adaptive immune responses?

Antigen presentation

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagolysosomal fusion

Which of the following is NOT a function of phagocytes?

Producing antibodies

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

Which type of leukocytes takes several days to leave the bloodstream and differentiate into macrophages?

Monocytes

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Transendothelial migration

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagolysosome formation

Which enzymes digest the pathogen in the phagolysosome?

Lysozyme, phospholipase, and proteases

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Phagocytosis

Which of the following is NOT a mechanism used by phagocytes to kill pathogens?

Production of antibodies

What is the name of the process by which phagocytes provide an intracellular signal that activates the phagocyte, causing it to transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

Which of the following is NOT a function of phagocytes?

Producing antibodies against pathogens

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Extravasation

Which type of leukocytes are the last to arrive and differentiate into macrophages?

Monocytes

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process called when the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagolysosome formation

Which of the following is NOT a mechanism used by phagocytes to kill pathogens?

Production of antibodies

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Phagocytosis

Which of the following is NOT a type of leukocyte involved in phagocytosis?

Lymphocytes

What is the name of the process by which leukocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

Which of the following is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Transendothelial migration

Which of the following cells are the first to arrive within hours of a bacterial infection?

Neutrophils

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagolysosome formation

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What are the lysosomal enzymes that digest the pathogen in the phagolysosome?

Lysozyme, phospholipase, and proteases

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Extravasation

What is the name of the process by which phagocytes provide an intracellular signal that activates the phagocyte, causing it to transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process by which the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue?

Transendothelial migration

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

All of the above

What is the name of the process by which some phagocytes even contain an internal storehouse of microbicidal defensin proteins, which can be released into the area around the cell to degrade microbes externally?

Defensin release

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagolysosome formation

What are the molecular structures on phagocytes that recognize pathogen-associated molecular patterns (PAMPs) called?

PRRs

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What type of cells are responsible for seeking, ingesting, and killing pathogens through phagocytosis?

Phagocytes

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Extravasation

Which type of leukocytes are the first to arrive within hours of a bacterial infection?

Neutrophils

What are the molecular structures that are common to many groups of pathogenic microbes called?

PAMPs

Which type of leukocytes may take several days to leave the bloodstream and differentiate into macrophages?

Monocytes

What is the name of the process by which the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What type of cells are also antigen-presenting cells involved in the specific adaptive immune response, further processing the remains of the degraded pathogen and presenting key antigens on their cellular surface, an important step for stimulation of some adaptive immune responses?

Macrophages and dendritic cells

What is the name of the process by which phagocytes provide an intracellular signal that activates the phagocyte, causing it to transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the process by which leukocytes are able to reach pathogens located in infected tissue called?

Extravasation

Which of the following is NOT a function of phagocytes?

Adapting

What are the molecular structures that phagocytes recognize that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which phagocytes transition from a dormant state of readiness to a state of hyperactivity, proliferation, and enhanced intracellular killing?

Activation

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Transendothelial migration

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Lysosomal fusion

Which of the following is NOT a mechanism of pathogen destruction by phagocytes?

Release of antibodies

Which type of leukocytes may take several days to leave the bloodstream and differentiate into macrophages?

Monocytes

What is the name of the process by which phagocytes release microbicidal defensin proteins into the area around the cell to degrade microbes externally?

Exocytosis

What is the function of macrophages and dendritic cells in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Cytokine production

What is the name of the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue?

Extravasation

Which of the following is the first type of leukocyte to arrive, often within hours of a bacterial infection?

Neutrophils

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

Which type of leukocytes are the first to arrive within hours of a bacterial infection?

Neutrophils

What do pattern recognition receptors (PRRs) on macrophages do?

Provide an intracellular signal that activates the phagocyte

What is the name of the process by which phagocytes recognize molecular structures that are common to many groups of pathogenic microbes, called pathogen-associated molecular patterns (PAMPs)?

Pattern recognition

What is the name of the process by which the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Margination

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Phagosome-lysosome fusion

Which enzymes digest the pathogen in the phagolysosome?

Lysozyme, phospholipase, and proteases

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Phagocytosis

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process by which some phagocytes contain an internal storehouse of microbicidal defensin proteins, which can be released into the area around the cell to degrade microbes externally?

Exocytosis

What is the name of the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue?

Extravasation

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What type of leukocytes are the first to arrive, often within hours of a bacterial infection?

Neutrophils

What are the molecular structures that are common to many groups of pathogenic microbes called?

Pathogen-associated molecular patterns (PAMPs)

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Transendothelial migration

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Lysosomal fusion

What type of cells are involved in the specific adaptive immune response, further processing the remains of the degraded pathogen and presenting key antigens on their cellular surface, an important step for stimulation of some adaptive immune responses?

Macrophages and dendritic cells

What is the name of the process by which leukocytes may take several days to leave the bloodstream and differentiate into macrophages?

Monocyte differentiation

What is the name of the process by which phagocytes provide an intracellular signal that activates the phagocyte, causing it to transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the process called when the pathogen is engulfed in a vesicle and brought into the internal compartment of the phagocyte?

Phagocytosis

What are the molecular structures on phagocytes that recognize pathogen-associated molecular patterns (PAMPs) called?

Pattern recognition receptors (PRRs)

What enzymes digest the pathogen in the phagolysosome?

Lysozyme, phospholipase, and proteases

What is the process by which leukocytes pass through the walls of small capillary blood vessels within tissues to reach pathogens located in infected tissue called?

Extravasation

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Lysosomal fusion

What is the name of the process by which phagocytes transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

Which of the following is NOT a type of phagocyte?

Lymphocytes

What are the molecular structures on phagocytes that recognize pathogen-associated molecular patterns (PAMPs) called?

PRRs

What type of leukocytes are the first to arrive within hours of a bacterial infection?

Neutrophils

What is the name of the process by which leukocytes stick slightly to the adhesion molecules, slowing down and rolling along the blood vessel walls near the infected area, before binding to even more of these adhesion molecules and squeezing through the cellular junction?

Extravasation

What is the name of the process by which phagocytes provide an intracellular signal that activates the phagocyte, causing it to transition from a dormant state of readiness and slow proliferation to a state of hyperactivity, proliferation, production/secretion of cytokines, and enhanced intracellular killing?

Activation

What is the name of the process by which the phagosome containing the pathogen fuses with one or more lysosomes, forming a phagolysosome, which enhances the acidification, essential for activation of pH-dependent digestive lysosomal enzymes and production of hydrogen peroxide and toxic reactive oxygen species?

Lysosomal fusion

Which of the following is an important early antibacterial mechanism during phagocytosis?

Acidification of the phagosome

What are macrophages and dendritic cells also involved in, in addition to being antigen-presenting cells involved in the specific adaptive immune response?

Phagocytosis

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