Test your knowledge of Nick-seq, a high-resolution method for mapping DNA modifi...
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Test your knowledge of Nick-seq, a high-resolution method for mapping DNA modifi...

Test your knowledge of Nick-seq, a high-resolution method for mapping DNA modifications and damage, with this quiz. This quiz covers the principles, applications, and significance of Nick-seq in genomic research.

Created by
@LuckiestLlama

Questions and Answers

Genomic DNA in all cells is continuously subjected to extensive ______ modification including damage caused by endogenous and exogenous stresses (1), intermediates in the repair of this damage (1), and enzymatically-mediated epigenetic modifications (2). These mechanisms and processes are well established to have profound influences on genome stability and cell phenotype, with dysregulation causing many human diseases

chemical

While whole-genome sequencing is now commonplace in the post-genomic era, with the mutational consequences of DNA damage readily mapped across genomes, technologies to accurately and quantitatively localize DNA ______ in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in Table 1. For example, single-nucleotide-resolution genomi

modifications

______ for single-nucleotide resolution genomic maps of DNA modifications and damage

Nick-seq

technologies to accurately and quantitatively localize DNA modifications in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in Table 1. For example, single-nucleotide-resolution genomi

<p>genomics</p> Signup and view all the answers

Genomic DNA in all cells is continuously subjected to extensive ______ modification including damage caused by endogenous and exogenous stresses (1), intermediates in the repair of this damage (1), and enzymatically-mediated epigenetic modifications (2). These mechanisms and processes are well established to have profound influences on genome stability and cell phenotype, with dysregulation causing many human diseases

<p>chemical</p> Signup and view all the answers

While whole-genome sequencing is now commonplace in the post-genomic era, with the mutational consequences of DNA damage readily mapped across genomes, technologies to accurately and quantitatively ______ DNA modifications in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in Table 1. For example, single-nucleotide-resolution genomi

<p>localize</p> Signup and view all the answers

______ for single-nucleotide resolution genomic maps of DNA modifications and damage

<p>Nick-seq</p> Signup and view all the answers

technologies to accurately and quantitatively localize DNA modifications in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in ______. For example, single-nucleotide-resolution genomi

<p>Table 1</p> Signup and view all the answers

damage caused by endogenous and exogenous stresses (1), intermediates in the ______ of this damage (1), and enzymatically-mediated epigenetic modifications (2). These mechanisms and processes are well established to have profound influences on genome stability and cell phenotype, with dysregulation causing many human diseases

<p>repair</p> Signup and view all the answers

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