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Genomic DNA in all cells is continuously subjected to extensive ______ modification including damage caused by endogenous and exogenous stresses (1), intermediates in the repair of this damage (1), and enzymatically-mediated epigenetic modifications (2). These mechanisms and processes are well established to have profound influences on genome stability and cell phenotype, with dysregulation causing many human diseases
chemical
While whole-genome sequencing is now commonplace in the post-genomic era, with the mutational consequences of DNA damage readily mapped across genomes, technologies to accurately and quantitatively localize DNA ______ in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in Table 1. For example, single-nucleotide-resolution genomi
modifications
______ for single-nucleotide resolution genomic maps of DNA modifications and damage
Nick-seq
technologies to accurately and quantitatively localize DNA modifications in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in Table 1. For example, single-nucleotide-resolution genomi
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Genomic DNA in all cells is continuously subjected to extensive ______ modification including damage caused by endogenous and exogenous stresses (1), intermediates in the repair of this damage (1), and enzymatically-mediated epigenetic modifications (2). These mechanisms and processes are well established to have profound influences on genome stability and cell phenotype, with dysregulation causing many human diseases
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While whole-genome sequencing is now commonplace in the post-genomic era, with the mutational consequences of DNA damage readily mapped across genomes, technologies to accurately and quantitatively ______ DNA modifications in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in Table 1. For example, single-nucleotide-resolution genomi
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______ for single-nucleotide resolution genomic maps of DNA modifications and damage
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technologies to accurately and quantitatively localize DNA modifications in genomes are limited and highly specialized. A summary of existing methods for DNA modification mapping is presented in ______. For example, single-nucleotide-resolution genomi
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damage caused by endogenous and exogenous stresses (1), intermediates in the ______ of this damage (1), and enzymatically-mediated epigenetic modifications (2). These mechanisms and processes are well established to have profound influences on genome stability and cell phenotype, with dysregulation causing many human diseases
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